Linking the FTO obesity rs1421085 variant circuitry to cellular, metabolic, and organismal phenotypes in vivo.
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| Title: | Linking the FTO obesity rs1421085 variant circuitry to cellular, metabolic, and organismal phenotypes in vivo. |
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| Authors: | Laber S; Mammalian Genetics Unit, MRC Harwell Institute, Oxfordshire OX11 0RD, UK. slaber@broadinstitute.org sara.forcisi@helmholtz-muenchen.de melina@broadinstitute.org r.cox@har.mrc.ac.uk.; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Forcisi S; Research Unit Analytical BioGeoChemistry, Helmholtz Zentrum München, Neuherberg, Germany. slaber@broadinstitute.org sara.forcisi@helmholtz-muenchen.de melina@broadinstitute.org r.cox@har.mrc.ac.uk.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Bentley L; Mammalian Genetics Unit, MRC Harwell Institute, Oxfordshire OX11 0RD, UK., Petzold J; Institute of Nutritional Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany., Moritz F; Research Unit Analytical BioGeoChemistry, Helmholtz Zentrum München, Neuherberg, Germany., Smirnov KS; Research Unit Analytical BioGeoChemistry, Helmholtz Zentrum München, Neuherberg, Germany., Al Sadat L; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Else Kröner-Fresenius-Centre for Nutritional Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany., Williamson I; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh, UK., Strobel S; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute of Nutritional Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany., Agnew T; Mammalian Genetics Unit, MRC Harwell Institute, Oxfordshire OX11 0RD, UK., Sengupta S; Mammalian Genetics Unit, MRC Harwell Institute, Oxfordshire OX11 0RD, UK., Nicol T; Mammalian Genetics Unit, MRC Harwell Institute, Oxfordshire OX11 0RD, UK., Grallert H; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Center Munich, Germany., Heier M; KORA Study Center Augsburg, University Hospital of Augsburg, Augsburg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, Munich, Germany., Honecker J; Else Kröner-Fresenius-Centre for Nutritional Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany., Mianne J; Mary Lyon Centre, MRC Harwell Institute, Oxfordshire, UK., Teboul L; Mary Lyon Centre, MRC Harwell Institute, Oxfordshire, UK., Dumbell R; Mammalian Genetics Unit, MRC Harwell Institute, Oxfordshire OX11 0RD, UK., Long H; Mammalian Genetics Unit, MRC Harwell Institute, Oxfordshire OX11 0RD, UK.; Nuffield Department of Medicine, University of Oxford, Henry Wellcome Building for Molecular Physiology, Old Road Campus, Headington, Oxford OX3 7BN, UK., Simon M; Mammalian Genetics Unit, MRC Harwell Institute, Oxfordshire OX11 0RD, UK., Lindgren C; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA.; National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford OX3 9DU, UK., Bickmore WA; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh, UK., Hauner H; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Nutritional Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.; Else Kröner-Fresenius-Centre for Nutritional Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany., Schmitt-Kopplin P; Research Unit Analytical BioGeoChemistry, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Analytical Food Chemistry, Technical University of Munich, Freising, Germany., Claussnitzer M; Broad Institute of MIT and Harvard, Cambridge, MA, USA. slaber@broadinstitute.org sara.forcisi@helmholtz-muenchen.de melina@broadinstitute.org r.cox@har.mrc.ac.uk.; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; Institute for Aging Research, Hebrew SeniorLife and Harvard Medical School, Boston, MA, USA., Cox RD; Mammalian Genetics Unit, MRC Harwell Institute, Oxfordshire OX11 0RD, UK. slaber@broadinstitute.org sara.forcisi@helmholtz-muenchen.de melina@broadinstitute.org r.cox@har.mrc.ac.uk. |
| Source: | Science advances [Sci Adv] 2021 Jul 21; Vol. 7 (30). Date of Electronic Publication: 2021 Jul 21 (Print Publication: 2021). |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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