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Novel Humanized Mesothelin-Expressing Genetically Engineered Mouse Models Underscore Challenges in Delivery of Complex Therapeutics to Pancreatic Cancers.

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Title: Novel Humanized Mesothelin-Expressing Genetically Engineered Mouse Models Underscore Challenges in Delivery of Complex Therapeutics to Pancreatic Cancers.
Authors: Hagerty B; Laboratory of Molecular Biology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.; Surgical Oncology Program, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., O'Sullivan TN; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, NCI, Frederick, Maryland., Zhang X; Laboratory of Molecular Biology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Collins NK; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, NCI, Frederick, Maryland., Custer Lawrence W; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, NCI, Frederick, Maryland., Bassel LL; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, NCI, Frederick, Maryland., Pate N; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, NCI, Frederick, Maryland., Xu J; Laboratory of Molecular Biology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Guerin TM; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, NCI, Frederick, Maryland., Kozlov S; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, NCI, Frederick, Maryland. alewinecc@mail.nih.gov christine.alewine@nih.gov kozlovse@nci.gov., Alewine C; Laboratory of Molecular Biology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland. alewinecc@mail.nih.gov christine.alewine@nih.gov kozlovse@nci.gov.
Source: Molecular cancer therapeutics [Mol Cancer Ther] 2021 Oct; Vol. 20 (10), pp. 2082-2092. Date of Electronic Publication: 2021 Jul 26.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
Journal Info: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1538-8514
DOI:10.1158/1535-7163.MCT-21-0017