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Novel Humanized Mesothelin-Expressing Genetically Engineered Mouse Models Underscore Challenges in Delivery of Complex Therapeutics to Pancreatic Cancers.

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Title: Novel Humanized Mesothelin-Expressing Genetically Engineered Mouse Models Underscore Challenges in Delivery of Complex Therapeutics to Pancreatic Cancers.
Authors: Hagerty B; Laboratory of Molecular Biology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.; Surgical Oncology Program, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., O'Sullivan TN; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, NCI, Frederick, Maryland., Zhang X; Laboratory of Molecular Biology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Collins NK; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, NCI, Frederick, Maryland., Custer Lawrence W; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, NCI, Frederick, Maryland., Bassel LL; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, NCI, Frederick, Maryland., Pate N; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, NCI, Frederick, Maryland., Xu J; Laboratory of Molecular Biology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Guerin TM; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, NCI, Frederick, Maryland., Kozlov S; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, NCI, Frederick, Maryland. alewinecc@mail.nih.gov christine.alewine@nih.gov kozlovse@nci.gov., Alewine C; Laboratory of Molecular Biology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland. alewinecc@mail.nih.gov christine.alewine@nih.gov kozlovse@nci.gov.
Source: Molecular cancer therapeutics [Mol Cancer Ther] 2021 Oct; Vol. 20 (10), pp. 2082-2092. Date of Electronic Publication: 2021 Jul 26.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
Journal Info: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Novel Humanized Mesothelin-Expressing Genetically Engineered Mouse Models Underscore Challenges in Delivery of Complex Therapeutics to Pancreatic Cancers.
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  Data: <searchLink fieldCode="AU" term="%22Hagerty+B%22">Hagerty B</searchLink>; Laboratory of Molecular Biology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.; Surgical Oncology Program, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22O'Sullivan+TN%22">O'Sullivan TN</searchLink>; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, NCI, Frederick, Maryland.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Laboratory of Molecular Biology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Collins+NK%22">Collins NK</searchLink>; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, NCI, Frederick, Maryland.<br /><searchLink fieldCode="AU" term="%22Custer+Lawrence+W%22">Custer Lawrence W</searchLink>; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, NCI, Frederick, Maryland.<br /><searchLink fieldCode="AU" term="%22Bassel+LL%22">Bassel LL</searchLink>; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, NCI, Frederick, Maryland.<br /><searchLink fieldCode="AU" term="%22Pate+N%22">Pate N</searchLink>; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, NCI, Frederick, Maryland.<br /><searchLink fieldCode="AU" term="%22Xu+J%22">Xu J</searchLink>; Laboratory of Molecular Biology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Guerin+TM%22">Guerin TM</searchLink>; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, NCI, Frederick, Maryland.<br /><searchLink fieldCode="AU" term="%22Kozlov+S%22">Kozlov S</searchLink>; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, NCI, Frederick, Maryland. alewinecc@mail.nih.gov christine.alewine@nih.gov kozlovse@nci.gov.<br /><searchLink fieldCode="AU" term="%22Alewine+C%22">Alewine C</searchLink>; Laboratory of Molecular Biology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland. alewinecc@mail.nih.gov christine.alewine@nih.gov kozlovse@nci.gov.
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  Data: <searchLink fieldCode="JN" term="%22101132535%22">Molecular cancer therapeutics</searchLink> [Mol Cancer Ther] 2021 Oct; Vol. 20 (10), pp. 2082-2092. <i>Date of Electronic Publication: </i>2021 Jul 26.
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  Data: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%2C+Inc%22">American Association for Cancer Research, Inc </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101132535 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1538-8514 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215357163%22">15357163 </searchLink><i>NLM ISO Abbreviation: </i>Mol Cancer Ther <i>Subsets: </i>MEDLINE
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