Implication of specific retinal cell-type involvement and gene expression changes in AMD progression using integrative analysis of single-cell and bulk RNA-seq profiling.
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| Title: | Implication of specific retinal cell-type involvement and gene expression changes in AMD progression using integrative analysis of single-cell and bulk RNA-seq profiling. |
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| Authors: | Lyu Y; Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA., Zauhar R; Department of Chemistry and Biochemistry, The University of the Sciences in Philadelphia, Philadelphia, PA, 19104, USA., Dana N; Departments of Ophthalmology and Human Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA., Strang CE; Department of Psychology, University of Alabama At Birmingham, Birmingham, AL, 35294, USA., Hu J; Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA., Wang K; Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.; Department of Information Theory and Data Science, School of Mathematical Sciences and LPMC, Nankai University, Tianjin, 30071, China., Liu S; Department of Biochemistry and Molecular Genetics, University of Alabama At Birmingham, Birmingham, AL, 35294, USA., Pan N; Department of Computer and Information Science, University of Pennsylvania, Philadelphia, PA, 19104, USA., Gamlin P; Department of Ophthalmology and Visual Sciences, University of Alabama At Birmingham, Birmingham, AL, 35294, USA., Kimble JA; Department of Ophthalmology and Visual Sciences, University of Alabama At Birmingham, Birmingham, AL, 35294, USA., Messinger JD; Department of Ophthalmology and Visual Sciences, University of Alabama At Birmingham, Birmingham, AL, 35294, USA., Curcio CA; Department of Ophthalmology and Visual Sciences, University of Alabama At Birmingham, Birmingham, AL, 35294, USA., Stambolian D; Departments of Ophthalmology and Human Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA. stamboli@pennmedicine.upenn.edu., Li M; Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA. mingyao@pennmedicine.upenn.edu. |
| Source: | Scientific reports [Sci Rep] 2021 Aug 02; Vol. 11 (1), pp. 15612. Date of Electronic Publication: 2021 Aug 02. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep |
| Database: | MEDLINE Ultimate |
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