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Discovery of a dual Ras and ARF6 inhibitor from a GPCR endocytosis screen.

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Title: Discovery of a dual Ras and ARF6 inhibitor from a GPCR endocytosis screen.
Authors: Giubilaro J; Department of Pharmacology and Therapeutics, McGill University, Montréal, QC, Canada.; Research Institute of the McGill University Health Center (RI-MUHC), Montreal, QC, Canada., Schuetz DA; Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, QC, Canada., Stepniewski TM; Research Programme on Biomedical Informatics (GRIB), Department of Experimental and Health Sciences of Pompeu, Fabra University (UPF)-Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.; InterAx Biotech AG, Villigen, Switzerland., Namkung Y; Research Institute of the McGill University Health Center (RI-MUHC), Montreal, QC, Canada.; Department of Medicine, Research Institute of the McGill University Health Center (RI-MUHC), McGill University, Montréal, QC, Canada., Khoury E; Department of Medicine, Research Institute of the McGill University Health Center (RI-MUHC), McGill University, Montréal, QC, Canada., Lara-Márquez M; Research Institute of the McGill University Health Center (RI-MUHC), Montreal, QC, Canada.; Department of Anatomy and Cell Biology, McGill University, Montréal, QC, Canada., Campbell S; Department of Pharmacology and Physiology, Université de Montréal, Montréal, QC, Canada., Beautrait A; Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, QC, Canada.; Schrödinger, Inc., New York, NY, United States., Armando S; Department of Medicine, Research Institute of the McGill University Health Center (RI-MUHC), McGill University, Montréal, QC, Canada., Radresa O; Department of Medicine, Research Institute of the McGill University Health Center (RI-MUHC), McGill University, Montréal, QC, Canada., Duchaine J; Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, QC, Canada., Lamarche-Vane N; Research Institute of the McGill University Health Center (RI-MUHC), Montreal, QC, Canada.; Department of Anatomy and Cell Biology, McGill University, Montréal, QC, Canada., Claing A; Department of Pharmacology and Physiology, Université de Montréal, Montréal, QC, Canada., Selent J; Research Programme on Biomedical Informatics (GRIB), Department of Experimental and Health Sciences of Pompeu, Fabra University (UPF)-Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain., Bouvier M; Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, QC, Canada.; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, QC, Canada., Marinier A; Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, QC, Canada., Laporte SA; Department of Pharmacology and Therapeutics, McGill University, Montréal, QC, Canada. stephane.laporte@mcgill.ca.; Research Institute of the McGill University Health Center (RI-MUHC), Montreal, QC, Canada. stephane.laporte@mcgill.ca.; Department of Medicine, Research Institute of the McGill University Health Center (RI-MUHC), McGill University, Montréal, QC, Canada. stephane.laporte@mcgill.ca.
Source: Nature communications [Nat Commun] 2021 Aug 03; Vol. 12 (1), pp. 4688. Date of Electronic Publication: 2021 Aug 03.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Giubilaro+J%22">Giubilaro J</searchLink>; Department of Pharmacology and Therapeutics, McGill University, Montréal, QC, Canada.; Research Institute of the McGill University Health Center (RI-MUHC), Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Schuetz+DA%22">Schuetz DA</searchLink>; Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Stepniewski+TM%22">Stepniewski TM</searchLink>; Research Programme on Biomedical Informatics (GRIB), Department of Experimental and Health Sciences of Pompeu, Fabra University (UPF)-Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.; InterAx Biotech AG, Villigen, Switzerland.<br /><searchLink fieldCode="AU" term="%22Namkung+Y%22">Namkung Y</searchLink>; Research Institute of the McGill University Health Center (RI-MUHC), Montreal, QC, Canada.; Department of Medicine, Research Institute of the McGill University Health Center (RI-MUHC), McGill University, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Khoury+E%22">Khoury E</searchLink>; Department of Medicine, Research Institute of the McGill University Health Center (RI-MUHC), McGill University, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Lara-Márquez+M%22">Lara-Márquez M</searchLink>; Research Institute of the McGill University Health Center (RI-MUHC), Montreal, QC, Canada.; Department of Anatomy and Cell Biology, McGill University, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Campbell+S%22">Campbell S</searchLink>; Department of Pharmacology and Physiology, Université de Montréal, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Beautrait+A%22">Beautrait A</searchLink>; Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, QC, Canada.; Schrödinger, Inc., New York, NY, United States.<br /><searchLink fieldCode="AU" term="%22Armando+S%22">Armando S</searchLink>; Department of Medicine, Research Institute of the McGill University Health Center (RI-MUHC), McGill University, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Radresa+O%22">Radresa O</searchLink>; Department of Medicine, Research Institute of the McGill University Health Center (RI-MUHC), McGill University, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Duchaine+J%22">Duchaine J</searchLink>; Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Lamarche-Vane+N%22">Lamarche-Vane N</searchLink>; Research Institute of the McGill University Health Center (RI-MUHC), Montreal, QC, Canada.; Department of Anatomy and Cell Biology, McGill University, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Claing+A%22">Claing A</searchLink>; Department of Pharmacology and Physiology, Université de Montréal, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Selent+J%22">Selent J</searchLink>; Research Programme on Biomedical Informatics (GRIB), Department of Experimental and Health Sciences of Pompeu, Fabra University (UPF)-Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Bouvier+M%22">Bouvier M</searchLink>; Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, QC, Canada.; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Marinier+A%22">Marinier A</searchLink>; Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Laporte+SA%22">Laporte SA</searchLink>; Department of Pharmacology and Therapeutics, McGill University, Montréal, QC, Canada. stephane.laporte@mcgill.ca.; Research Institute of the McGill University Health Center (RI-MUHC), Montreal, QC, Canada. stephane.laporte@mcgill.ca.; Department of Medicine, Research Institute of the McGill University Health Center (RI-MUHC), McGill University, Montréal, QC, Canada. stephane.laporte@mcgill.ca.
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