Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia.
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| Title: | Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia. |
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| Authors: | Sartori R; Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.; Veneto Institute of Molecular Medicine, 35129 Padova, Italy.; Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy., Hagg A; Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.; Centre for Muscle Research, Department of Anatomy and Physiology, University of Melbourne, Melbourne, VIC 3010, Australia.; Biomedicine Discovery Institute, Department of Physiology, Monash University, Melbourne, VIC 3800, Australia., Zampieri S; Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy.; Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padova, 35128 Padua, Italy.; Myology Center, University of Padova, 35122 Padua, Italy., Armani A; Veneto Institute of Molecular Medicine, 35129 Padova, Italy.; Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy., Winbanks CE; Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia., Viana LR; Centre for Muscle Research, Department of Anatomy and Physiology, University of Melbourne, Melbourne, VIC 3010, Australia.; Department of Structural and Functional Biology, Biology Institute, University of Campinas, Campinas, São Paulo 13083-97, Brazil., Haidar M; The Florey Institute of Neuroscience and Mental Health, Parkville, VIC 3052, Australia., Watt KI; Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.; Centre for Muscle Research, Department of Anatomy and Physiology, University of Melbourne, Melbourne, VIC 3010, Australia., Qian H; Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.; Centre for Muscle Research, Department of Anatomy and Physiology, University of Melbourne, Melbourne, VIC 3010, Australia., Pezzini C; Veneto Institute of Molecular Medicine, 35129 Padova, Italy.; Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy., Zanganeh P; The Florey Institute of Neuroscience and Mental Health, Parkville, VIC 3052, Australia., Turner BJ; The Florey Institute of Neuroscience and Mental Health, Parkville, VIC 3052, Australia., Larsson A; Theme Cancer, Karolinska University Hospital, Solna 171 76, Sweden., Zanchettin G; Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padova, 35128 Padua, Italy., Pierobon ES; Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padova, 35128 Padua, Italy., Moletta L; Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padova, 35128 Padua, Italy., Valmasoni M; Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padova, 35128 Padua, Italy., Ponzoni A; Department of Radiology, Padova General Hospital, 35121 Padova, Italy., Attar S; Department of Medicine, University Hospital of Padova, 35121 Padova, Italy., Da Dalt G; Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padova, 35128 Padua, Italy., Sperti C; Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padova, 35128 Padua, Italy., Kustermann M; Center for Anatomy and Cell Biology, Medical University of Vienna, 1090 Vienna, Austria., Thomson RE; Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.; Centre for Muscle Research, Department of Anatomy and Physiology, University of Melbourne, Melbourne, VIC 3010, Australia., Larsson L; Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden.; Department of Clinical Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden.; Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA 16802, USA., Loveland KL; Centre for Reproductive Health. Hudson Institute of Medical Research, Clayton, VIC 3168, Australia.; Department of Molecular and Translational Sciences, and Anatomy and Developmental Biology, Monash University, VIC 3800, Australia., Costelli P; Department of Clinical and Biological Sciences, University of Turin, 10125 Turin, Italy., Megighian A; Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy., Merigliano S; Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padova, 35128 Padua, Italy., Penna F; Department of Clinical and Biological Sciences, University of Turin, 10125 Turin, Italy., Gregorevic P; Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia. pgre@unimelb.edu.au marco.sandri@unipd.it.; Centre for Muscle Research, Department of Anatomy and Physiology, University of Melbourne, Melbourne, VIC 3010, Australia.; Department of Biochemistry and Molecular Biology, Monash University, VIC 3800, Australia.; Department of Neurology, University of Washington School of Medicine, Seattle, WA 98195, USA., Sandri M; Veneto Institute of Molecular Medicine, 35129 Padova, Italy. pgre@unimelb.edu.au marco.sandri@unipd.it.; Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy.; Myology Center, University of Padova, 35122 Padua, Italy.; Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada. |
| Source: | Science translational medicine [Sci Transl Med] 2021 Aug 04; Vol. 13 (605). |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1946-6242 |
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| DOI: | 10.1126/scitranslmed.aay9592 |
