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Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia.

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Title: Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia.
Authors: Sartori R; Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.; Veneto Institute of Molecular Medicine, 35129 Padova, Italy.; Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy., Hagg A; Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.; Centre for Muscle Research, Department of Anatomy and Physiology, University of Melbourne, Melbourne, VIC 3010, Australia.; Biomedicine Discovery Institute, Department of Physiology, Monash University, Melbourne, VIC 3800, Australia., Zampieri S; Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy.; Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padova, 35128 Padua, Italy.; Myology Center, University of Padova, 35122 Padua, Italy., Armani A; Veneto Institute of Molecular Medicine, 35129 Padova, Italy.; Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy., Winbanks CE; Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia., Viana LR; Centre for Muscle Research, Department of Anatomy and Physiology, University of Melbourne, Melbourne, VIC 3010, Australia.; Department of Structural and Functional Biology, Biology Institute, University of Campinas, Campinas, São Paulo 13083-97, Brazil., Haidar M; The Florey Institute of Neuroscience and Mental Health, Parkville, VIC 3052, Australia., Watt KI; Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.; Centre for Muscle Research, Department of Anatomy and Physiology, University of Melbourne, Melbourne, VIC 3010, Australia., Qian H; Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.; Centre for Muscle Research, Department of Anatomy and Physiology, University of Melbourne, Melbourne, VIC 3010, Australia., Pezzini C; Veneto Institute of Molecular Medicine, 35129 Padova, Italy.; Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy., Zanganeh P; The Florey Institute of Neuroscience and Mental Health, Parkville, VIC 3052, Australia., Turner BJ; The Florey Institute of Neuroscience and Mental Health, Parkville, VIC 3052, Australia., Larsson A; Theme Cancer, Karolinska University Hospital, Solna 171 76, Sweden., Zanchettin G; Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padova, 35128 Padua, Italy., Pierobon ES; Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padova, 35128 Padua, Italy., Moletta L; Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padova, 35128 Padua, Italy., Valmasoni M; Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padova, 35128 Padua, Italy., Ponzoni A; Department of Radiology, Padova General Hospital, 35121 Padova, Italy., Attar S; Department of Medicine, University Hospital of Padova, 35121 Padova, Italy., Da Dalt G; Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padova, 35128 Padua, Italy., Sperti C; Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padova, 35128 Padua, Italy., Kustermann M; Center for Anatomy and Cell Biology, Medical University of Vienna, 1090 Vienna, Austria., Thomson RE; Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.; Centre for Muscle Research, Department of Anatomy and Physiology, University of Melbourne, Melbourne, VIC 3010, Australia., Larsson L; Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden.; Department of Clinical Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden.; Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA 16802, USA., Loveland KL; Centre for Reproductive Health. Hudson Institute of Medical Research, Clayton, VIC 3168, Australia.; Department of Molecular and Translational Sciences, and Anatomy and Developmental Biology, Monash University, VIC 3800, Australia., Costelli P; Department of Clinical and Biological Sciences, University of Turin, 10125 Turin, Italy., Megighian A; Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy., Merigliano S; Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padova, 35128 Padua, Italy., Penna F; Department of Clinical and Biological Sciences, University of Turin, 10125 Turin, Italy., Gregorevic P; Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia. pgre@unimelb.edu.au marco.sandri@unipd.it.; Centre for Muscle Research, Department of Anatomy and Physiology, University of Melbourne, Melbourne, VIC 3010, Australia.; Department of Biochemistry and Molecular Biology, Monash University, VIC 3800, Australia.; Department of Neurology, University of Washington School of Medicine, Seattle, WA 98195, USA., Sandri M; Veneto Institute of Molecular Medicine, 35129 Padova, Italy. pgre@unimelb.edu.au marco.sandri@unipd.it.; Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy.; Myology Center, University of Padova, 35122 Padua, Italy.; Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada.
Source: Science translational medicine [Sci Transl Med] 2021 Aug 04; Vol. 13 (605).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia.
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  Data: <searchLink fieldCode="AU" term="%22Sartori+R%22">Sartori R</searchLink>; Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.; Veneto Institute of Molecular Medicine, 35129 Padova, Italy.; Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Hagg+A%22">Hagg A</searchLink>; Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.; Centre for Muscle Research, Department of Anatomy and Physiology, University of Melbourne, Melbourne, VIC 3010, Australia.; Biomedicine Discovery Institute, Department of Physiology, Monash University, Melbourne, VIC 3800, Australia.<br /><searchLink fieldCode="AU" term="%22Zampieri+S%22">Zampieri S</searchLink>; Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy.; Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padova, 35128 Padua, Italy.; Myology Center, University of Padova, 35122 Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Armani+A%22">Armani A</searchLink>; Veneto Institute of Molecular Medicine, 35129 Padova, Italy.; Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Winbanks+CE%22">Winbanks CE</searchLink>; Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.<br /><searchLink fieldCode="AU" term="%22Viana+LR%22">Viana LR</searchLink>; Centre for Muscle Research, Department of Anatomy and Physiology, University of Melbourne, Melbourne, VIC 3010, Australia.; Department of Structural and Functional Biology, Biology Institute, University of Campinas, Campinas, São Paulo 13083-97, Brazil.<br /><searchLink fieldCode="AU" term="%22Haidar+M%22">Haidar M</searchLink>; The Florey Institute of Neuroscience and Mental Health, Parkville, VIC 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Watt+KI%22">Watt KI</searchLink>; Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.; Centre for Muscle Research, Department of Anatomy and Physiology, University of Melbourne, Melbourne, VIC 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Qian+H%22">Qian H</searchLink>; Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.; Centre for Muscle Research, Department of Anatomy and Physiology, University of Melbourne, Melbourne, VIC 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Pezzini+C%22">Pezzini C</searchLink>; Veneto Institute of Molecular Medicine, 35129 Padova, Italy.; Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Zanganeh+P%22">Zanganeh P</searchLink>; The Florey Institute of Neuroscience and Mental Health, Parkville, VIC 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Turner+BJ%22">Turner BJ</searchLink>; The Florey Institute of Neuroscience and Mental Health, Parkville, VIC 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Larsson+A%22">Larsson A</searchLink>; Theme Cancer, Karolinska University Hospital, Solna 171 76, Sweden.<br /><searchLink fieldCode="AU" term="%22Zanchettin+G%22">Zanchettin G</searchLink>; Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padova, 35128 Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Pierobon+ES%22">Pierobon ES</searchLink>; Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padova, 35128 Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Moletta+L%22">Moletta L</searchLink>; Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padova, 35128 Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Valmasoni+M%22">Valmasoni M</searchLink>; Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padova, 35128 Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Ponzoni+A%22">Ponzoni A</searchLink>; Department of Radiology, Padova General Hospital, 35121 Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Attar+S%22">Attar S</searchLink>; Department of Medicine, University Hospital of Padova, 35121 Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Da+Dalt+G%22">Da Dalt G</searchLink>; Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padova, 35128 Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Sperti+C%22">Sperti C</searchLink>; Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padova, 35128 Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Kustermann+M%22">Kustermann M</searchLink>; Center for Anatomy and Cell Biology, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Thomson+RE%22">Thomson RE</searchLink>; Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.; Centre for Muscle Research, Department of Anatomy and Physiology, University of Melbourne, Melbourne, VIC 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Larsson+L%22">Larsson L</searchLink>; Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden.; Department of Clinical Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden.; Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA 16802, USA.<br /><searchLink fieldCode="AU" term="%22Loveland+KL%22">Loveland KL</searchLink>; Centre for Reproductive Health. Hudson Institute of Medical Research, Clayton, VIC 3168, Australia.; Department of Molecular and Translational Sciences, and Anatomy and Developmental Biology, Monash University, VIC 3800, Australia.<br /><searchLink fieldCode="AU" term="%22Costelli+P%22">Costelli P</searchLink>; Department of Clinical and Biological Sciences, University of Turin, 10125 Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Megighian+A%22">Megighian A</searchLink>; Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Merigliano+S%22">Merigliano S</searchLink>; Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padova, 35128 Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Penna+F%22">Penna F</searchLink>; Department of Clinical and Biological Sciences, University of Turin, 10125 Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Gregorevic+P%22">Gregorevic P</searchLink>; Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia. pgre@unimelb.edu.au marco.sandri@unipd.it.; Centre for Muscle Research, Department of Anatomy and Physiology, University of Melbourne, Melbourne, VIC 3010, Australia.; Department of Biochemistry and Molecular Biology, Monash University, VIC 3800, Australia.; Department of Neurology, University of Washington School of Medicine, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Sandri+M%22">Sandri M</searchLink>; Veneto Institute of Molecular Medicine, 35129 Padova, Italy. pgre@unimelb.edu.au marco.sandri@unipd.it.; Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy.; Myology Center, University of Padova, 35122 Padua, Italy.; Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada.
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