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Perivascular spaces are associated with tau pathophysiology and synaptic dysfunction in early Alzheimer's continuum.

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Title: Perivascular spaces are associated with tau pathophysiology and synaptic dysfunction in early Alzheimer's continuum.
Authors: Vilor-Tejedor N; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain. nvilor@barcelonabeta.org.; Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, Barcelona, Spain. nvilor@barcelonabeta.org.; Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands. nvilor@barcelonabeta.org.; Universitat Pompeu Fabra, Barcelona, Spain. nvilor@barcelonabeta.org., Ciampa I; Department of Radiology, Hospital Universitari Sagrat Cor, Barcelona, Spain., Operto G; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Fragilidad Y Envejecimiento Saludable (CIBERFES), Madrid, Spain., Falcón C; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Centro de Investigación Biomédica en Red Bioingeniería, Biomateriales Y Nanomedicina, Madrid, Spain., Suárez-Calvet M; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Fragilidad Y Envejecimiento Saludable (CIBERFES), Madrid, Spain.; Servei de Neurologia, Hospital del Mar, Barcelona, Spain., Crous-Bou M; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), Hospitalet del Llobregat, Spain., Shekari M; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain., Arenaza-Urquijo EM; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Fragilidad Y Envejecimiento Saludable (CIBERFES), Madrid, Spain., Milà-Alomà M; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Fragilidad Y Envejecimiento Saludable (CIBERFES), Madrid, Spain., Grau-Rivera O; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Fragilidad Y Envejecimiento Saludable (CIBERFES), Madrid, Spain.; Servei de Neurologia, Hospital del Mar, Barcelona, Spain., Minguillon C; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Fragilidad Y Envejecimiento Saludable (CIBERFES), Madrid, Spain., Kollmorgen G; Roche Diagnostics GmbH, Penzberg, Germany., Zetterberg H; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.; Dementia Research Institute At UCL, London, UK., Blennow K; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden., Guigo R; Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain., Molinuevo JL; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain. jlmolinuevo@barcelonabeta.org.; Universitat Pompeu Fabra, Barcelona, Spain. jlmolinuevo@barcelonabeta.org.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain. jlmolinuevo@barcelonabeta.org.; Centro de Investigación Biomédica en Red de Fragilidad Y Envejecimiento Saludable (CIBERFES), Madrid, Spain. jlmolinuevo@barcelonabeta.org., Gispert JD; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain. jdgispert@barcelonabeta.org.; Universitat Pompeu Fabra, Barcelona, Spain. jdgispert@barcelonabeta.org.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain. jdgispert@barcelonabeta.org.; Centro de Investigación Biomédica en Red Bioingeniería, Biomateriales Y Nanomedicina, Madrid, Spain. jdgispert@barcelonabeta.org.
Corporate Authors: ALFA study
Source: Alzheimer's research & therapy [Alzheimers Res Ther] 2021 Aug 05; Vol. 13 (1), pp. 135. Date of Electronic Publication: 2021 Aug 05.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101511643 Publication Model: Electronic Cited Medium: Internet ISSN: 1758-9193 (Electronic) NLM ISO Abbreviation: Alzheimers Res Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Perivascular spaces are associated with tau pathophysiology and synaptic dysfunction in early Alzheimer's continuum.
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  Data: <searchLink fieldCode="AU" term="%22Vilor-Tejedor+N%22">Vilor-Tejedor N</searchLink>; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain. nvilor@barcelonabeta.org.; Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, Barcelona, Spain. nvilor@barcelonabeta.org.; Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands. nvilor@barcelonabeta.org.; Universitat Pompeu Fabra, Barcelona, Spain. nvilor@barcelonabeta.org.<br /><searchLink fieldCode="AU" term="%22Ciampa+I%22">Ciampa I</searchLink>; Department of Radiology, Hospital Universitari Sagrat Cor, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Operto+G%22">Operto G</searchLink>; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Fragilidad Y Envejecimiento Saludable (CIBERFES), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Falcón+C%22">Falcón C</searchLink>; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Centro de Investigación Biomédica en Red Bioingeniería, Biomateriales Y Nanomedicina, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Suárez-Calvet+M%22">Suárez-Calvet M</searchLink>; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Fragilidad Y Envejecimiento Saludable (CIBERFES), Madrid, Spain.; Servei de Neurologia, Hospital del Mar, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Crous-Bou+M%22">Crous-Bou M</searchLink>; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), Hospitalet del Llobregat, Spain.<br /><searchLink fieldCode="AU" term="%22Shekari+M%22">Shekari M</searchLink>; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Arenaza-Urquijo+EM%22">Arenaza-Urquijo EM</searchLink>; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Fragilidad Y Envejecimiento Saludable (CIBERFES), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Milà-Alomà+M%22">Milà-Alomà M</searchLink>; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Fragilidad Y Envejecimiento Saludable (CIBERFES), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Grau-Rivera+O%22">Grau-Rivera O</searchLink>; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Fragilidad Y Envejecimiento Saludable (CIBERFES), Madrid, Spain.; Servei de Neurologia, Hospital del Mar, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Minguillon+C%22">Minguillon C</searchLink>; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Fragilidad Y Envejecimiento Saludable (CIBERFES), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Kollmorgen+G%22">Kollmorgen G</searchLink>; Roche Diagnostics GmbH, Penzberg, Germany.<br /><searchLink fieldCode="AU" term="%22Zetterberg+H%22">Zetterberg H</searchLink>; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.; Dementia Research Institute At UCL, London, UK.<br /><searchLink fieldCode="AU" term="%22Blennow+K%22">Blennow K</searchLink>; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Guigo+R%22">Guigo R</searchLink>; Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Molinuevo+JL%22">Molinuevo JL</searchLink>; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain. jlmolinuevo@barcelonabeta.org.; Universitat Pompeu Fabra, Barcelona, Spain. jlmolinuevo@barcelonabeta.org.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain. jlmolinuevo@barcelonabeta.org.; Centro de Investigación Biomédica en Red de Fragilidad Y Envejecimiento Saludable (CIBERFES), Madrid, Spain. jlmolinuevo@barcelonabeta.org.<br /><searchLink fieldCode="AU" term="%22Gispert+JD%22">Gispert JD</searchLink>; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain. jdgispert@barcelonabeta.org.; Universitat Pompeu Fabra, Barcelona, Spain. jdgispert@barcelonabeta.org.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain. jdgispert@barcelonabeta.org.; Centro de Investigación Biomédica en Red Bioingeniería, Biomateriales Y Nanomedicina, Madrid, Spain. jdgispert@barcelonabeta.org.
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  Data: <searchLink fieldCode="JN" term="%22101511643%22">Alzheimer's research & therapy</searchLink> [Alzheimers Res Ther] 2021 Aug 05; Vol. 13 (1), pp. 135. <i>Date of Electronic Publication: </i>2021 Aug 05.
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