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Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies.

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Title: Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies.
Authors: Kerns SJ; Emulate Inc, Boston, United States., Belgur C; Emulate Inc, Boston, United States., Petropolis D; Emulate Inc, Boston, United States., Kanellias M; Emulate Inc, Boston, United States., Barrile R; Emulate Inc, Boston, United States.; Department of Biomedical Engineering, University of Cincinnati, Cincinnati, United States., Sam J; Roche Pharma Research & Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland., Weinzierl T; Roche Pharma Research & Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland., Fauti T; Roche Pharma Research & Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland., Freimoser-Grundschober A; Roche Pharma Research & Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland., Eckmann J; Roche Pharma Research & Early Development, Roche Innovation Center Munich, Penzberg, Germany., Hage C; Roche Pharma Research & Early Development, Roche Innovation Center Munich, Penzberg, Germany., Geiger M; Roche Pharma Research & Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland., Ng PR; Emulate Inc, Boston, United States., Tien-Street W; Emulate Inc, Boston, United States., Manatakis DV; Emulate Inc, Boston, United States., Micallef V; Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland., Gerard R; Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland., Bscheider M; Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland., Breous-Nystrom E; Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland., Schneider A; Roche Pharma Research & Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland., Giusti AM; Roche Pharma Research & Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland., Bertinetti-Lapatki C; Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland., Grant HS; Emulate Inc, Boston, United States., Roth AB; Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland., Hamilton GA; Emulate Inc, Boston, United States., Singer T; Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland., Karalis K; Emulate Inc, Boston, United States., Moisan A; Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland., Bruenker P; Roche Pharma Research & Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland., Klein C; Roche Pharma Research & Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland., Bacac M; Roche Pharma Research & Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland., Gjorevski N; Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland., Cabon L; Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland.
Source: ELife [Elife] 2021 Aug 11; Vol. 10. Date of Electronic Publication: 2021 Aug 11.
Publication Type: Evaluation Study; Journal Article
Journal Info: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
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