Neuronal Nsun2 deficiency produces tRNA epitranscriptomic alterations and proteomic shifts impacting synaptic signaling and behavior.
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| Title: | Neuronal Nsun2 deficiency produces tRNA epitranscriptomic alterations and proteomic shifts impacting synaptic signaling and behavior. |
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| Authors: | Blaze J; Department of Neuroscience, Icahn School of Medicine at Mt. Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mt. Sinai, New York, NY, USA., Navickas A; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA., Phillips HL; Departments of Psychiatry and Behavioral Sciences, Neuroscience and Physiology, Upstate Medical University, Syracuse, NY, USA., Heissel S; The Rockefeller University Proteomics Resource Center, The Rockefeller University, New York, NY, USA., Plaza-Jennings A; Department of Psychiatry, Icahn School of Medicine at Mt. Sinai, New York, NY, USA., Miglani S; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA., Asgharian H; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA., Foo M; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA., Katanski CD; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA., Watkins CP; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA., Pennington ZT; Department of Neuroscience, Icahn School of Medicine at Mt. Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mt. Sinai, New York, NY, USA., Javidfar B; Friedman Brain Institute, Icahn School of Medicine at Mt. Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mt. Sinai, New York, NY, USA., Espeso-Gil S; Friedman Brain Institute, Icahn School of Medicine at Mt. Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mt. Sinai, New York, NY, USA., Rostandy B; The Rockefeller University Proteomics Resource Center, The Rockefeller University, New York, NY, USA., Alwaseem H; The Rockefeller University Proteomics Resource Center, The Rockefeller University, New York, NY, USA., Hahn CG; Department of Neurosciences, Thomas Jefferson University, Philadelphia, PA, USA., Molina H; The Rockefeller University Proteomics Resource Center, The Rockefeller University, New York, NY, USA., Cai DJ; Department of Neuroscience, Icahn School of Medicine at Mt. Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mt. Sinai, New York, NY, USA., Pan T; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA., Yao WD; Departments of Psychiatry and Behavioral Sciences, Neuroscience and Physiology, Upstate Medical University, Syracuse, NY, USA., Goodarzi H; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA., Haghighi F; Department of Neuroscience, Icahn School of Medicine at Mt. Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mt. Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mt. Sinai, New York, NY, USA.; Research and Development Service, James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA., Akbarian S; Department of Neuroscience, Icahn School of Medicine at Mt. Sinai, New York, NY, USA. schahram.akbarian@mssm.edu.; Friedman Brain Institute, Icahn School of Medicine at Mt. Sinai, New York, NY, USA. schahram.akbarian@mssm.edu.; Department of Psychiatry, Icahn School of Medicine at Mt. Sinai, New York, NY, USA. schahram.akbarian@mssm.edu. |
| Source: | Nature communications [Nat Commun] 2021 Aug 13; Vol. 12 (1), pp. 4913. Date of Electronic Publication: 2021 Aug 13. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-021-24969-x |
