BET bromodomain protein inhibition reverses chimeric antigen receptor extinction and reinvigorates exhausted T cells in chronic lymphocytic leukemia.

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Title: BET bromodomain protein inhibition reverses chimeric antigen receptor extinction and reinvigorates exhausted T cells in chronic lymphocytic leukemia.
Authors: Kong W; Department of Microbiology.; Center for Cellular Immunotherapies.; Abramson Cancer Center, and., Dimitri A; Department of Microbiology.; Center for Cellular Immunotherapies.; Abramson Cancer Center, and., Wang W; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Jung IY; Department of Microbiology.; Center for Cellular Immunotherapies.; Abramson Cancer Center, and., Ott CJ; Department of Medicine, Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts, USA., Fasolino M; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Wang Y; Center for Cellular Immunotherapies., Kulikovskaya I; Center for Cellular Immunotherapies., Gupta M; Center for Cellular Immunotherapies., Yoder T; Center for Cellular Immunotherapies., DeNizio JE; Department of Medicine and.; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Everett JK; Department of Microbiology., Williams EF; Department of Microbiology.; Center for Cellular Immunotherapies.; Abramson Cancer Center, and., Xu J; Center for Cellular Immunotherapies., Scholler J; Center for Cellular Immunotherapies., Reich TJ; Center for Cellular Immunotherapies., Bhoj VG; Center for Cellular Immunotherapies.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Haines KM; Center for Cellular Immunotherapies., Maus MV; Department of Medicine, Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts, USA., Melenhorst JJ; Center for Cellular Immunotherapies.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Young RM; Center for Cellular Immunotherapies., Jadlowsky JK; Center for Cellular Immunotherapies., Marcucci KT; Center for Cellular Immunotherapies., Bradner JE; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA., Levine BL; Center for Cellular Immunotherapies.; Abramson Cancer Center, and.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Porter DL; Abramson Cancer Center, and.; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Bushman FD; Department of Microbiology., Kohli RM; Department of Medicine and.; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania, USA., June CH; Center for Cellular Immunotherapies.; Abramson Cancer Center, and.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Davis MM; Center for Cellular Immunotherapies.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Lacey SF; Center for Cellular Immunotherapies.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Vahedi G; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Fraietta JA; Department of Microbiology.; Center for Cellular Immunotherapies.; Abramson Cancer Center, and.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Source: The Journal of clinical investigation [J Clin Invest] 2021 Aug 16; Vol. 131 (16).
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1558-8238
DOI:10.1172/JCI145459