BET bromodomain protein inhibition reverses chimeric antigen receptor extinction and reinvigorates exhausted T cells in chronic lymphocytic leukemia.
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| Title: | BET bromodomain protein inhibition reverses chimeric antigen receptor extinction and reinvigorates exhausted T cells in chronic lymphocytic leukemia. |
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| Authors: | Kong W; Department of Microbiology.; Center for Cellular Immunotherapies.; Abramson Cancer Center, and., Dimitri A; Department of Microbiology.; Center for Cellular Immunotherapies.; Abramson Cancer Center, and., Wang W; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Jung IY; Department of Microbiology.; Center for Cellular Immunotherapies.; Abramson Cancer Center, and., Ott CJ; Department of Medicine, Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts, USA., Fasolino M; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Wang Y; Center for Cellular Immunotherapies., Kulikovskaya I; Center for Cellular Immunotherapies., Gupta M; Center for Cellular Immunotherapies., Yoder T; Center for Cellular Immunotherapies., DeNizio JE; Department of Medicine and.; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Everett JK; Department of Microbiology., Williams EF; Department of Microbiology.; Center for Cellular Immunotherapies.; Abramson Cancer Center, and., Xu J; Center for Cellular Immunotherapies., Scholler J; Center for Cellular Immunotherapies., Reich TJ; Center for Cellular Immunotherapies., Bhoj VG; Center for Cellular Immunotherapies.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Haines KM; Center for Cellular Immunotherapies., Maus MV; Department of Medicine, Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts, USA., Melenhorst JJ; Center for Cellular Immunotherapies.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Young RM; Center for Cellular Immunotherapies., Jadlowsky JK; Center for Cellular Immunotherapies., Marcucci KT; Center for Cellular Immunotherapies., Bradner JE; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA., Levine BL; Center for Cellular Immunotherapies.; Abramson Cancer Center, and.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Porter DL; Abramson Cancer Center, and.; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Bushman FD; Department of Microbiology., Kohli RM; Department of Medicine and.; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania, USA., June CH; Center for Cellular Immunotherapies.; Abramson Cancer Center, and.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Davis MM; Center for Cellular Immunotherapies.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Lacey SF; Center for Cellular Immunotherapies.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Vahedi G; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Fraietta JA; Department of Microbiology.; Center for Cellular Immunotherapies.; Abramson Cancer Center, and.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, Pennsylvania, USA. |
| Source: | The Journal of clinical investigation [J Clin Invest] 2021 Aug 16; Vol. 131 (16). |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 34396987 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: BET bromodomain protein inhibition reverses chimeric antigen receptor extinction and reinvigorates exhausted T cells in chronic lymphocytic leukemia. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Kong+W%22">Kong W</searchLink>; Department of Microbiology.; Center for Cellular Immunotherapies.; Abramson Cancer Center, and.<br /><searchLink fieldCode="AU" term="%22Dimitri+A%22">Dimitri A</searchLink>; Department of Microbiology.; Center for Cellular Immunotherapies.; Abramson Cancer Center, and.<br /><searchLink fieldCode="AU" term="%22Wang+W%22">Wang W</searchLink>; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Jung+IY%22">Jung IY</searchLink>; Department of Microbiology.; Center for Cellular Immunotherapies.; Abramson Cancer Center, and.<br /><searchLink fieldCode="AU" term="%22Ott+CJ%22">Ott CJ</searchLink>; Department of Medicine, Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Fasolino+M%22">Fasolino M</searchLink>; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Center for Cellular Immunotherapies.<br /><searchLink fieldCode="AU" term="%22Kulikovskaya+I%22">Kulikovskaya I</searchLink>; Center for Cellular Immunotherapies.<br /><searchLink fieldCode="AU" term="%22Gupta+M%22">Gupta M</searchLink>; Center for Cellular Immunotherapies.<br /><searchLink fieldCode="AU" term="%22Yoder+T%22">Yoder T</searchLink>; Center for Cellular Immunotherapies.<br /><searchLink fieldCode="AU" term="%22DeNizio+JE%22">DeNizio JE</searchLink>; Department of Medicine and.; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Everett+JK%22">Everett JK</searchLink>; Department of Microbiology.<br /><searchLink fieldCode="AU" term="%22Williams+EF%22">Williams EF</searchLink>; Department of Microbiology.; Center for Cellular Immunotherapies.; Abramson Cancer Center, and.<br /><searchLink fieldCode="AU" term="%22Xu+J%22">Xu J</searchLink>; Center for Cellular Immunotherapies.<br /><searchLink fieldCode="AU" term="%22Scholler+J%22">Scholler J</searchLink>; Center for Cellular Immunotherapies.<br /><searchLink fieldCode="AU" term="%22Reich+TJ%22">Reich TJ</searchLink>; Center for Cellular Immunotherapies.<br /><searchLink fieldCode="AU" term="%22Bhoj+VG%22">Bhoj VG</searchLink>; Center for Cellular Immunotherapies.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Haines+KM%22">Haines KM</searchLink>; Center for Cellular Immunotherapies.<br /><searchLink fieldCode="AU" term="%22Maus+MV%22">Maus MV</searchLink>; Department of Medicine, Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Melenhorst+JJ%22">Melenhorst JJ</searchLink>; Center for Cellular Immunotherapies.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Young+RM%22">Young RM</searchLink>; Center for Cellular Immunotherapies.<br /><searchLink fieldCode="AU" term="%22Jadlowsky+JK%22">Jadlowsky JK</searchLink>; Center for Cellular Immunotherapies.<br /><searchLink fieldCode="AU" term="%22Marcucci+KT%22">Marcucci KT</searchLink>; Center for Cellular Immunotherapies.<br /><searchLink fieldCode="AU" term="%22Bradner+JE%22">Bradner JE</searchLink>; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Levine+BL%22">Levine BL</searchLink>; Center for Cellular Immunotherapies.; Abramson Cancer Center, and.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Porter+DL%22">Porter DL</searchLink>; Abramson Cancer Center, and.; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Bushman+FD%22">Bushman FD</searchLink>; Department of Microbiology.<br /><searchLink fieldCode="AU" term="%22Kohli+RM%22">Kohli RM</searchLink>; Department of Medicine and.; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22June+CH%22">June CH</searchLink>; Center for Cellular Immunotherapies.; Abramson Cancer Center, and.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Davis+MM%22">Davis MM</searchLink>; Center for Cellular Immunotherapies.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Lacey+SF%22">Lacey SF</searchLink>; Center for Cellular Immunotherapies.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Vahedi+G%22">Vahedi G</searchLink>; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Fraietta+JA%22">Fraietta JA</searchLink>; Department of Microbiology.; Center for Cellular Immunotherapies.; Abramson Cancer Center, and.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, Pennsylvania, USA. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%227802877%22">The Journal of clinical investigation</searchLink> [J Clin Invest] 2021 Aug 16; Vol. 131 (16). – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+for+Clinical+Investigation%22">American Society for Clinical Investigation </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7802877 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1558-8238 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200219738%22">00219738 </searchLink><i>NLM ISO Abbreviation: </i>J Clin Invest <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=34396987 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1172/JCI145459 Languages: – Code: eng Text: English Titles: – TitleFull: BET bromodomain protein inhibition reverses chimeric antigen receptor extinction and reinvigorates exhausted T cells in chronic lymphocytic leukemia. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kong W – PersonEntity: Name: NameFull: Dimitri A – PersonEntity: Name: NameFull: Wang W – PersonEntity: Name: NameFull: Jung IY – PersonEntity: Name: NameFull: Ott CJ – PersonEntity: Name: NameFull: Fasolino M – PersonEntity: Name: NameFull: Wang Y – PersonEntity: Name: NameFull: Kulikovskaya I – PersonEntity: Name: NameFull: Gupta M – PersonEntity: Name: NameFull: Yoder T – PersonEntity: Name: NameFull: DeNizio JE – PersonEntity: Name: NameFull: Everett JK – PersonEntity: Name: NameFull: Williams EF – PersonEntity: Name: NameFull: Xu J – PersonEntity: Name: NameFull: Scholler J – PersonEntity: Name: NameFull: Reich TJ – PersonEntity: Name: NameFull: Bhoj VG – PersonEntity: Name: NameFull: Haines KM – PersonEntity: Name: NameFull: Maus MV – PersonEntity: Name: NameFull: Melenhorst JJ – PersonEntity: Name: NameFull: Young RM – PersonEntity: Name: NameFull: Jadlowsky JK – PersonEntity: Name: NameFull: Marcucci KT – PersonEntity: Name: NameFull: Bradner JE – PersonEntity: Name: NameFull: Levine BL – PersonEntity: Name: NameFull: Porter DL – PersonEntity: Name: NameFull: Bushman FD – PersonEntity: Name: NameFull: Kohli RM – PersonEntity: Name: NameFull: June CH – PersonEntity: Name: NameFull: Davis MM – PersonEntity: Name: NameFull: Lacey SF – PersonEntity: Name: NameFull: Vahedi G – PersonEntity: Name: NameFull: Fraietta JA IsPartOfRelationships: – BibEntity: Dates: – D: 16 M: 08 Text: 2021 Aug 16 Type: published Y: 2021 Identifiers: – Type: issn-electronic Value: 1558-8238 Numbering: – Type: volume Value: 131 – Type: issue Value: 16 Titles: – TitleFull: The Journal of clinical investigation Type: main |
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