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The HIV protease inhibitor, ritonavir, corrects diverse brain phenotypes across development in mouse model of DYT-TOR1A dystonia.

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Title: The HIV protease inhibitor, ritonavir, corrects diverse brain phenotypes across development in mouse model of DYT-TOR1A dystonia.
Authors: Caffall ZF; Department of Neurology, Duke University Medical Center, Durham, NC 27715, USA., Wilkes BJ; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA., Hernández-Martinez R; Department of Neurology, Duke University Medical Center, Durham, NC 27715, USA., Rittiner JE; Department of Neurology, Duke University Medical Center, Durham, NC 27715, USA., Fox JT; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Wan KK; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Shipman MK; Department of Neurology, Duke University Medical Center, Durham, NC 27715, USA., Titus SA; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Zhang YQ; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Patnaik S; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Hall MD; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Boxer MB; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Shen M; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Li Z; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Vaillancourt DE; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA.; Department of Neurology, Fixel Institute for Neurological Diseases, McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA., Calakos N; Department of Neurology, Duke University Medical Center, Durham, NC 27715, USA. nicole.calakos@duke.edu.; Department of Neurobiology, Duke University Medical Center, Durham, NC 27715, USA.; Department of Cell Biology, Duke University Medical Center, Durham, NC 27715, USA.; Duke Institute for Brain Sciences, Duke University, Durham, NC 27715, USA.
Source: Science translational medicine [Sci Transl Med] 2021 Aug 18; Vol. 13 (607).
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The HIV protease inhibitor, ritonavir, corrects diverse brain phenotypes across development in mouse model of DYT-TOR1A dystonia.
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  Data: <searchLink fieldCode="AU" term="%22Caffall+ZF%22">Caffall ZF</searchLink>; Department of Neurology, Duke University Medical Center, Durham, NC 27715, USA.<br /><searchLink fieldCode="AU" term="%22Wilkes+BJ%22">Wilkes BJ</searchLink>; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA.<br /><searchLink fieldCode="AU" term="%22Hernández-Martinez+R%22">Hernández-Martinez R</searchLink>; Department of Neurology, Duke University Medical Center, Durham, NC 27715, USA.<br /><searchLink fieldCode="AU" term="%22Rittiner+JE%22">Rittiner JE</searchLink>; Department of Neurology, Duke University Medical Center, Durham, NC 27715, USA.<br /><searchLink fieldCode="AU" term="%22Fox+JT%22">Fox JT</searchLink>; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Wan+KK%22">Wan KK</searchLink>; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Shipman+MK%22">Shipman MK</searchLink>; Department of Neurology, Duke University Medical Center, Durham, NC 27715, USA.<br /><searchLink fieldCode="AU" term="%22Titus+SA%22">Titus SA</searchLink>; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+YQ%22">Zhang YQ</searchLink>; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Patnaik+S%22">Patnaik S</searchLink>; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Hall+MD%22">Hall MD</searchLink>; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Boxer+MB%22">Boxer MB</searchLink>; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Shen+M%22">Shen M</searchLink>; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Vaillancourt+DE%22">Vaillancourt DE</searchLink>; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA.; Department of Neurology, Fixel Institute for Neurological Diseases, McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA.<br /><searchLink fieldCode="AU" term="%22Calakos+N%22">Calakos N</searchLink>; Department of Neurology, Duke University Medical Center, Durham, NC 27715, USA. nicole.calakos@duke.edu.; Department of Neurobiology, Duke University Medical Center, Durham, NC 27715, USA.; Department of Cell Biology, Duke University Medical Center, Durham, NC 27715, USA.; Duke Institute for Brain Sciences, Duke University, Durham, NC 27715, USA.
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