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Optimization of Triarylpyridinone Inhibitors of the Main Protease of SARS-CoV-2 to Low-Nanomolar Antiviral Potency.

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Title: Optimization of Triarylpyridinone Inhibitors of the Main Protease of SARS-CoV-2 to Low-Nanomolar Antiviral Potency.
Authors: Zhang CH; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Spasov KA; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States., Reilly RA; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States., Hollander K; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States.; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States., Stone EA; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Ippolito JA; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Liosi ME; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Deshmukh MG; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States.; M.D.-Ph.D. Program, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States., Tirado-Rives J; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Zhang S; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut 06536-0812, United States., Liang Z; Department of Molecular, Cellular, and Developmental Biology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States., Miller SJ; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Isaacs F; Department of Molecular, Cellular, and Developmental Biology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States., Lindenbach BD; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut 06536-0812, United States., Anderson KS; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States.; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States., Jorgensen WL; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States.
Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2021 Jul 14; Vol. 12 (8), pp. 1325-1332. Date of Electronic Publication: 2021 Jul 14 (Print Publication: 2021).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE
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  Data: Optimization of Triarylpyridinone Inhibitors of the Main Protease of SARS-CoV-2 to Low-Nanomolar Antiviral Potency.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+CH%22">Zhang CH</searchLink>; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States.<br /><searchLink fieldCode="AU" term="%22Spasov+KA%22">Spasov KA</searchLink>; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States.<br /><searchLink fieldCode="AU" term="%22Reilly+RA%22">Reilly RA</searchLink>; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States.<br /><searchLink fieldCode="AU" term="%22Hollander+K%22">Hollander K</searchLink>; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States.; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States.<br /><searchLink fieldCode="AU" term="%22Stone+EA%22">Stone EA</searchLink>; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States.<br /><searchLink fieldCode="AU" term="%22Ippolito+JA%22">Ippolito JA</searchLink>; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States.<br /><searchLink fieldCode="AU" term="%22Liosi+ME%22">Liosi ME</searchLink>; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States.<br /><searchLink fieldCode="AU" term="%22Deshmukh+MG%22">Deshmukh MG</searchLink>; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States.; M.D.-Ph.D. Program, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States.<br /><searchLink fieldCode="AU" term="%22Tirado-Rives+J%22">Tirado-Rives J</searchLink>; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States.<br /><searchLink fieldCode="AU" term="%22Zhang+S%22">Zhang S</searchLink>; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut 06536-0812, United States.<br /><searchLink fieldCode="AU" term="%22Liang+Z%22">Liang Z</searchLink>; Department of Molecular, Cellular, and Developmental Biology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States.<br /><searchLink fieldCode="AU" term="%22Miller+SJ%22">Miller SJ</searchLink>; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States.<br /><searchLink fieldCode="AU" term="%22Isaacs+F%22">Isaacs F</searchLink>; Department of Molecular, Cellular, and Developmental Biology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States.<br /><searchLink fieldCode="AU" term="%22Lindenbach+BD%22">Lindenbach BD</searchLink>; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut 06536-0812, United States.<br /><searchLink fieldCode="AU" term="%22Anderson+KS%22">Anderson KS</searchLink>; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States.; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States.<br /><searchLink fieldCode="AU" term="%22Jorgensen+WL%22">Jorgensen WL</searchLink>; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States.
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