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Discovery of the First Non-cGMP Mimetic Small Molecule Activators of cGMP-Dependent Protein Kinase 1 α (PKG1α).

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Title: Discovery of the First Non-cGMP Mimetic Small Molecule Activators of cGMP-Dependent Protein Kinase 1 α (PKG1α).
Authors: Hanisak J; Discovery Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Soriano A; Mass Spectrometry and Biophysics, Computational and Structural Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Adam GC; Quantitative Biosciences, Merck & Co., Inc, West Point, Pennsylvania 19486, United States., Basso A; Mass Spectrometry and Biophysics, Computational and Structural Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Bauman D; Discovery Biology, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Bell D; Mass Spectrometry and Biophysics, Computational and Structural Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Frank E; Mass Spectrometry and Biophysics, Computational and Structural Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., O'Donnell G; Quantitative Biosciences, Merck & Co., Inc, West Point, Pennsylvania 19486, United States., Tawa P; Mass Spectrometry and Biophysics, Computational and Structural Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Verras A; Computational and Structural Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Yu Y; Discovery Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Zhang L; Biologics Analytical Research and Development, Merck & Co., Inc., Kenilworth, New Jersey, 07033 United States., Seganish WM; Discovery Chemistry, Merck & Co., Inc., South San Francisco, California 94080, United States.
Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2021 Jul 16; Vol. 12 (8), pp. 1275-1282. Date of Electronic Publication: 2021 Jul 16 (Print Publication: 2021).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Hanisak+J%22">Hanisak J</searchLink>; Discovery Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Soriano+A%22">Soriano A</searchLink>; Mass Spectrometry and Biophysics, Computational and Structural Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Adam+GC%22">Adam GC</searchLink>; Quantitative Biosciences, Merck & Co., Inc, West Point, Pennsylvania 19486, United States.<br /><searchLink fieldCode="AU" term="%22Basso+A%22">Basso A</searchLink>; Mass Spectrometry and Biophysics, Computational and Structural Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Bauman+D%22">Bauman D</searchLink>; Discovery Biology, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Bell+D%22">Bell D</searchLink>; Mass Spectrometry and Biophysics, Computational and Structural Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Frank+E%22">Frank E</searchLink>; Mass Spectrometry and Biophysics, Computational and Structural Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22O'Donnell+G%22">O'Donnell G</searchLink>; Quantitative Biosciences, Merck & Co., Inc, West Point, Pennsylvania 19486, United States.<br /><searchLink fieldCode="AU" term="%22Tawa+P%22">Tawa P</searchLink>; Mass Spectrometry and Biophysics, Computational and Structural Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Verras+A%22">Verras A</searchLink>; Computational and Structural Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Yu+Y%22">Yu Y</searchLink>; Discovery Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Biologics Analytical Research and Development, Merck & Co., Inc., Kenilworth, New Jersey, 07033 United States.<br /><searchLink fieldCode="AU" term="%22Seganish+WM%22">Seganish WM</searchLink>; Discovery Chemistry, Merck & Co., Inc., South San Francisco, California 94080, United States.
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