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Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10).

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Title: Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10).
Authors: Fushimi M; Tri-Institutional Therapeutics Discovery Institute, New York, New York 10021, United States., Buck H; Department of Pharmacology, Weill Cornell Medicine, New York, New York 10021, United States., Balbach M; Department of Pharmacology, Weill Cornell Medicine, New York, New York 10021, United States., Gorovyy A; Department of Pharmacology, Weill Cornell Medicine, New York, New York 10021, United States., Ferreira J; Department of Pharmacology, Weill Cornell Medicine, New York, New York 10021, United States., Rossetti T; Department of Pharmacology, Weill Cornell Medicine, New York, New York 10021, United States., Kaur N; Department of Pharmacology, Weill Cornell Medicine, New York, New York 10021, United States., Levin LR; Department of Pharmacology, Weill Cornell Medicine, New York, New York 10021, United States., Buck J; Department of Pharmacology, Weill Cornell Medicine, New York, New York 10021, United States., Quast J; Department of Biochemistry, University of Bayreuth, 95440 Bayreuth, Germany., van den Heuvel J; Helmholtz-Zentrum für Infektionsforschung, 38124 Braunschweig, Germany., Steegborn C; Department of Biochemistry, University of Bayreuth, 95440 Bayreuth, Germany., Finkin-Groner E; Tri-Institutional Therapeutics Discovery Institute, New York, New York 10021, United States., Kargman S; Tri-Institutional Therapeutics Discovery Institute, New York, New York 10021, United States., Michino M; Tri-Institutional Therapeutics Discovery Institute, New York, New York 10021, United States., Foley MA; Tri-Institutional Therapeutics Discovery Institute, New York, New York 10021, United States., Miller M; Tri-Institutional Therapeutics Discovery Institute, New York, New York 10021, United States., Liverton NJ; Tri-Institutional Therapeutics Discovery Institute, New York, New York 10021, United States., Huggins DJ; Tri-Institutional Therapeutics Discovery Institute, New York, New York 10021, United States.; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, New York 10021, United States., Meinke PT; Tri-Institutional Therapeutics Discovery Institute, New York, New York 10021, United States.; Department of Pharmacology, Weill Cornell Medicine, New York, New York 10021, United States.
Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2021 Jul 14; Vol. 12 (8), pp. 1283-1287. Date of Electronic Publication: 2021 Jul 14 (Print Publication: 2021).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE
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  Data: Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10).
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  Data: <searchLink fieldCode="AU" term="%22Fushimi+M%22">Fushimi M</searchLink>; Tri-Institutional Therapeutics Discovery Institute, New York, New York 10021, United States.<br /><searchLink fieldCode="AU" term="%22Buck+H%22">Buck H</searchLink>; Department of Pharmacology, Weill Cornell Medicine, New York, New York 10021, United States.<br /><searchLink fieldCode="AU" term="%22Balbach+M%22">Balbach M</searchLink>; Department of Pharmacology, Weill Cornell Medicine, New York, New York 10021, United States.<br /><searchLink fieldCode="AU" term="%22Gorovyy+A%22">Gorovyy A</searchLink>; Department of Pharmacology, Weill Cornell Medicine, New York, New York 10021, United States.<br /><searchLink fieldCode="AU" term="%22Ferreira+J%22">Ferreira J</searchLink>; Department of Pharmacology, Weill Cornell Medicine, New York, New York 10021, United States.<br /><searchLink fieldCode="AU" term="%22Rossetti+T%22">Rossetti T</searchLink>; Department of Pharmacology, Weill Cornell Medicine, New York, New York 10021, United States.<br /><searchLink fieldCode="AU" term="%22Kaur+N%22">Kaur N</searchLink>; Department of Pharmacology, Weill Cornell Medicine, New York, New York 10021, United States.<br /><searchLink fieldCode="AU" term="%22Levin+LR%22">Levin LR</searchLink>; Department of Pharmacology, Weill Cornell Medicine, New York, New York 10021, United States.<br /><searchLink fieldCode="AU" term="%22Buck+J%22">Buck J</searchLink>; Department of Pharmacology, Weill Cornell Medicine, New York, New York 10021, United States.<br /><searchLink fieldCode="AU" term="%22Quast+J%22">Quast J</searchLink>; Department of Biochemistry, University of Bayreuth, 95440 Bayreuth, Germany.<br /><searchLink fieldCode="AU" term="%22van+den+Heuvel+J%22">van den Heuvel J</searchLink>; Helmholtz-Zentrum für Infektionsforschung, 38124 Braunschweig, Germany.<br /><searchLink fieldCode="AU" term="%22Steegborn+C%22">Steegborn C</searchLink>; Department of Biochemistry, University of Bayreuth, 95440 Bayreuth, Germany.<br /><searchLink fieldCode="AU" term="%22Finkin-Groner+E%22">Finkin-Groner E</searchLink>; Tri-Institutional Therapeutics Discovery Institute, New York, New York 10021, United States.<br /><searchLink fieldCode="AU" term="%22Kargman+S%22">Kargman S</searchLink>; Tri-Institutional Therapeutics Discovery Institute, New York, New York 10021, United States.<br /><searchLink fieldCode="AU" term="%22Michino+M%22">Michino M</searchLink>; Tri-Institutional Therapeutics Discovery Institute, New York, New York 10021, United States.<br /><searchLink fieldCode="AU" term="%22Foley+MA%22">Foley MA</searchLink>; Tri-Institutional Therapeutics Discovery Institute, New York, New York 10021, United States.<br /><searchLink fieldCode="AU" term="%22Miller+M%22">Miller M</searchLink>; Tri-Institutional Therapeutics Discovery Institute, New York, New York 10021, United States.<br /><searchLink fieldCode="AU" term="%22Liverton+NJ%22">Liverton NJ</searchLink>; Tri-Institutional Therapeutics Discovery Institute, New York, New York 10021, United States.<br /><searchLink fieldCode="AU" term="%22Huggins+DJ%22">Huggins DJ</searchLink>; Tri-Institutional Therapeutics Discovery Institute, New York, New York 10021, United States.; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, New York 10021, United States.<br /><searchLink fieldCode="AU" term="%22Meinke+PT%22">Meinke PT</searchLink>; Tri-Institutional Therapeutics Discovery Institute, New York, New York 10021, United States.; Department of Pharmacology, Weill Cornell Medicine, New York, New York 10021, United States.
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  Data: <searchLink fieldCode="JN" term="%22101521073%22">ACS medicinal chemistry letters</searchLink> [ACS Med Chem Lett] 2021 Jul 14; Vol. 12 (8), pp. 1283-1287. <i>Date of Electronic Publication: </i>2021 Jul 14 (<i>Print Publication: </i>2021).
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