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Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides.

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Title: Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides.
Authors: Anderson BA; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Freestone GC; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Low A; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., De-Hoyos CL; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Iii WJD; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Østergaard ME; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Migawa MT; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Fazio M; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Wan WB; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Berdeja A; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Scandalis E; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Burel SA; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Vickers TA; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Crooke ST; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Swayze EE; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Liang X; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Seth PP; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.
Source: Nucleic acids research [Nucleic Acids Res] 2021 Sep 20; Vol. 49 (16), pp. 9026-9041.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Anderson+BA%22">Anderson BA</searchLink>; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.<br /><searchLink fieldCode="AU" term="%22Freestone+GC%22">Freestone GC</searchLink>; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.<br /><searchLink fieldCode="AU" term="%22Low+A%22">Low A</searchLink>; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.<br /><searchLink fieldCode="AU" term="%22De-Hoyos+CL%22">De-Hoyos CL</searchLink>; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.<br /><searchLink fieldCode="AU" term="%22Iii+WJD%22">Iii WJD</searchLink>; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.<br /><searchLink fieldCode="AU" term="%22Østergaard+ME%22">Østergaard ME</searchLink>; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.<br /><searchLink fieldCode="AU" term="%22Migawa+MT%22">Migawa MT</searchLink>; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.<br /><searchLink fieldCode="AU" term="%22Fazio+M%22">Fazio M</searchLink>; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.<br /><searchLink fieldCode="AU" term="%22Wan+WB%22">Wan WB</searchLink>; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.<br /><searchLink fieldCode="AU" term="%22Berdeja+A%22">Berdeja A</searchLink>; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.<br /><searchLink fieldCode="AU" term="%22Scandalis+E%22">Scandalis E</searchLink>; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.<br /><searchLink fieldCode="AU" term="%22Burel+SA%22">Burel SA</searchLink>; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.<br /><searchLink fieldCode="AU" term="%22Vickers+TA%22">Vickers TA</searchLink>; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.<br /><searchLink fieldCode="AU" term="%22Crooke+ST%22">Crooke ST</searchLink>; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.<br /><searchLink fieldCode="AU" term="%22Swayze+EE%22">Swayze EE</searchLink>; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.<br /><searchLink fieldCode="AU" term="%22Liang+X%22">Liang X</searchLink>; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.<br /><searchLink fieldCode="AU" term="%22Seth+PP%22">Seth PP</searchLink>; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.
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