Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides.
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| Title: | Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides. |
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| Authors: | Anderson BA; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Freestone GC; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Low A; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., De-Hoyos CL; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Iii WJD; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Østergaard ME; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Migawa MT; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Fazio M; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Wan WB; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Berdeja A; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Scandalis E; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Burel SA; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Vickers TA; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Crooke ST; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Swayze EE; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Liang X; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Seth PP; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA. |
| Source: | Nucleic acids research [Nucleic Acids Res] 2021 Sep 20; Vol. 49 (16), pp. 9026-9041. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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