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Molecular Subtyping Combined with Biological Pathway Analyses to Study Regorafenib Response in Clinically Relevant Mouse Models of Colorectal Cancer.

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Title: Molecular Subtyping Combined with Biological Pathway Analyses to Study Regorafenib Response in Clinically Relevant Mouse Models of Colorectal Cancer.
Authors: Lafferty A; Department of Physiology and Medical Physics, Precision Cancer Medicine Group, Royal College of Surgeons in Ireland, Dublin, Ireland., O'Farrell AC; Department of Physiology and Medical Physics, Precision Cancer Medicine Group, Royal College of Surgeons in Ireland, Dublin, Ireland., Migliardi G; Department of Oncology, University of Torino, Candiolo, Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy., Khemka N; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.; Center for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland., Lindner AU; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.; Center for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland., Sassi F; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy., Zanella ER; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy., Salvucci M; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.; Center for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland., Vanderheyden E; Department of Human Genetics, VIB Center for Cancer Biology, Leuven, Belgium, Laboratory for Translational Genetics, KU Leuven, Leuven, Belgium., Modave E; Department of Human Genetics, VIB Center for Cancer Biology, Leuven, Belgium, Laboratory for Translational Genetics, KU Leuven, Leuven, Belgium., Boeckx B; Department of Human Genetics, VIB Center for Cancer Biology, Leuven, Belgium, Laboratory for Translational Genetics, KU Leuven, Leuven, Belgium., Halang L; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.; Center for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland., Betge J; Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Junior Clinical Cooperation Unit Translational Gastrointestinal Oncology and Preclinical Models, German Cancer Research Center (DKFZ), Heidelberg, Germany., Ebert MPA; Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Dicker P; Department of Epidemiology and Public Health Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland., Argilés G; Vall d'Hebron University Hospital and Institute of Oncology (VHIO), Universitat Autònoma de Barcelona, CIBERONC, Barcelona, Spain., Tabernero J; Vall d'Hebron University Hospital and Institute of Oncology (VHIO), Universitat Autònoma de Barcelona, CIBERONC, Barcelona, Spain., Dienstmann R; Vall d'Hebron University Hospital and Institute of Oncology (VHIO), Universitat Autònoma de Barcelona, CIBERONC, Barcelona, Spain., Medico E; Department of Oncology, University of Torino, Candiolo, Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy., Lambrechts D; Department of Human Genetics, VIB Center for Cancer Biology, Leuven, Belgium, Laboratory for Translational Genetics, KU Leuven, Leuven, Belgium., Bertotti A; Department of Oncology, University of Torino, Candiolo, Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy., Isella C; Department of Oncology, University of Torino, Candiolo, Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy., Trusolino L; Department of Oncology, University of Torino, Candiolo, Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy., Prehn JHM; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.; Center for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland., Byrne AT; Department of Physiology and Medical Physics, Precision Cancer Medicine Group, Royal College of Surgeons in Ireland, Dublin, Ireland. annettebyrne@rcsi.ie.; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.; UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin, Ireland.
Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2021 Nov 01; Vol. 27 (21), pp. 5979-5992. Date of Electronic Publication: 2021 Aug 23.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Molecular Subtyping Combined with Biological Pathway Analyses to Study Regorafenib Response in Clinically Relevant Mouse Models of Colorectal Cancer.
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  Data: <searchLink fieldCode="AU" term="%22Lafferty+A%22">Lafferty A</searchLink>; Department of Physiology and Medical Physics, Precision Cancer Medicine Group, Royal College of Surgeons in Ireland, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22O'Farrell+AC%22">O'Farrell AC</searchLink>; Department of Physiology and Medical Physics, Precision Cancer Medicine Group, Royal College of Surgeons in Ireland, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Migliardi+G%22">Migliardi G</searchLink>; Department of Oncology, University of Torino, Candiolo, Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.<br /><searchLink fieldCode="AU" term="%22Khemka+N%22">Khemka N</searchLink>; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.; Center for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Lindner+AU%22">Lindner AU</searchLink>; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.; Center for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Sassi+F%22">Sassi F</searchLink>; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.<br /><searchLink fieldCode="AU" term="%22Zanella+ER%22">Zanella ER</searchLink>; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.<br /><searchLink fieldCode="AU" term="%22Salvucci+M%22">Salvucci M</searchLink>; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.; Center for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Vanderheyden+E%22">Vanderheyden E</searchLink>; Department of Human Genetics, VIB Center for Cancer Biology, Leuven, Belgium, Laboratory for Translational Genetics, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Modave+E%22">Modave E</searchLink>; Department of Human Genetics, VIB Center for Cancer Biology, Leuven, Belgium, Laboratory for Translational Genetics, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Boeckx+B%22">Boeckx B</searchLink>; Department of Human Genetics, VIB Center for Cancer Biology, Leuven, Belgium, Laboratory for Translational Genetics, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Halang+L%22">Halang L</searchLink>; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.; Center for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Betge+J%22">Betge J</searchLink>; Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Junior Clinical Cooperation Unit Translational Gastrointestinal Oncology and Preclinical Models, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Ebert+MPA%22">Ebert MPA</searchLink>; Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Dicker+P%22">Dicker P</searchLink>; Department of Epidemiology and Public Health Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Argilés+G%22">Argilés G</searchLink>; Vall d'Hebron University Hospital and Institute of Oncology (VHIO), Universitat Autònoma de Barcelona, CIBERONC, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Tabernero+J%22">Tabernero J</searchLink>; Vall d'Hebron University Hospital and Institute of Oncology (VHIO), Universitat Autònoma de Barcelona, CIBERONC, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Dienstmann+R%22">Dienstmann R</searchLink>; Vall d'Hebron University Hospital and Institute of Oncology (VHIO), Universitat Autònoma de Barcelona, CIBERONC, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Medico+E%22">Medico E</searchLink>; Department of Oncology, University of Torino, Candiolo, Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.<br /><searchLink fieldCode="AU" term="%22Lambrechts+D%22">Lambrechts D</searchLink>; Department of Human Genetics, VIB Center for Cancer Biology, Leuven, Belgium, Laboratory for Translational Genetics, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Bertotti+A%22">Bertotti A</searchLink>; Department of Oncology, University of Torino, Candiolo, Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.<br /><searchLink fieldCode="AU" term="%22Isella+C%22">Isella C</searchLink>; Department of Oncology, University of Torino, Candiolo, Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.<br /><searchLink fieldCode="AU" term="%22Trusolino+L%22">Trusolino L</searchLink>; Department of Oncology, University of Torino, Candiolo, Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.<br /><searchLink fieldCode="AU" term="%22Prehn+JHM%22">Prehn JHM</searchLink>; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.; Center for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Byrne+AT%22">Byrne AT</searchLink>; Department of Physiology and Medical Physics, Precision Cancer Medicine Group, Royal College of Surgeons in Ireland, Dublin, Ireland. annettebyrne@rcsi.ie.; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.; UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin, Ireland.
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  Data: <searchLink fieldCode="JN" term="%229502500%22">Clinical cancer research : an official journal of the American Association for Cancer Research</searchLink> [Clin Cancer Res] 2021 Nov 01; Vol. 27 (21), pp. 5979-5992. <i>Date of Electronic Publication: </i>2021 Aug 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9502500 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1557-3265 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210780432%22">10780432 </searchLink><i>NLM ISO Abbreviation: </i>Clin Cancer Res <i>Subsets: </i>MEDLINE
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