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Non-Toxic Dimeric Peptides Derived from the Bothropstoxin-I Are Potent SARS-CoV-2 and Papain-like Protease Inhibitors.

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Title: Non-Toxic Dimeric Peptides Derived from the Bothropstoxin-I Are Potent SARS-CoV-2 and Papain-like Protease Inhibitors.
Authors: Freire MCLC; São Carlos Institute of Physics, University of Sao Paulo, Avenida João Dagnone, 1100, São Carlos 13563-120, SP, Brazil., Noske GD; São Carlos Institute of Physics, University of Sao Paulo, Avenida João Dagnone, 1100, São Carlos 13563-120, SP, Brazil., Bitencourt NV; Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara 14800-060, SP, Brazil., Sanches PRS; Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara 14800-060, SP, Brazil., Santos-Filho NA; Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara 14800-060, SP, Brazil., Gawriljuk VO; São Carlos Institute of Physics, University of Sao Paulo, Avenida João Dagnone, 1100, São Carlos 13563-120, SP, Brazil., de Souza EP; Department of Genetics and Evolution, Federal University of São Carlos, Rodovia Washington Luís km 235, São Carlos 13565-905, SP, Brazil., Nogueira VHR; São Carlos Institute of Physics, University of Sao Paulo, Avenida João Dagnone, 1100, São Carlos 13563-120, SP, Brazil., de Godoy MO; São Carlos Institute of Physics, University of Sao Paulo, Avenida João Dagnone, 1100, São Carlos 13563-120, SP, Brazil., Nakamura AM; São Carlos Institute of Physics, University of Sao Paulo, Avenida João Dagnone, 1100, São Carlos 13563-120, SP, Brazil., Fernandes RS; São Carlos Institute of Physics, University of Sao Paulo, Avenida João Dagnone, 1100, São Carlos 13563-120, SP, Brazil., Godoy AS; São Carlos Institute of Physics, University of Sao Paulo, Avenida João Dagnone, 1100, São Carlos 13563-120, SP, Brazil., Juliano MA; The Sao Paulo School of Medicine, Federal University of São Paulo, Rua Três de Maio, 100, São Paulo 04044-020, SP, Brazil., Peres BM; Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes, 1374, São Paulo 05508-900, SP, Brazil., Barbosa CG; Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes, 1374, São Paulo 05508-900, SP, Brazil., Moraes CB; Department of Pharmaceutical Sciences, Federal University of São Paulo, Rua São Nicolau, 210, Diadema 09913-030, SP, Brazil., Freitas-Junior LHG; Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes, 1374, São Paulo 05508-900, SP, Brazil., Cilli EM; Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara 14800-060, SP, Brazil., Guido RVC; São Carlos Institute of Physics, University of Sao Paulo, Avenida João Dagnone, 1100, São Carlos 13563-120, SP, Brazil., Oliva G; São Carlos Institute of Physics, University of Sao Paulo, Avenida João Dagnone, 1100, São Carlos 13563-120, SP, Brazil.
Source: Molecules (Basel, Switzerland) [Molecules] 2021 Aug 12; Vol. 26 (16). Date of Electronic Publication: 2021 Aug 12.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules
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  Data: Non-Toxic Dimeric Peptides Derived from the Bothropstoxin-I Are Potent SARS-CoV-2 and Papain-like Protease Inhibitors.
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  Data: <searchLink fieldCode="AU" term="%22Freire+MCLC%22">Freire MCLC</searchLink>; São Carlos Institute of Physics, University of Sao Paulo, Avenida João Dagnone, 1100, São Carlos 13563-120, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Noske+GD%22">Noske GD</searchLink>; São Carlos Institute of Physics, University of Sao Paulo, Avenida João Dagnone, 1100, São Carlos 13563-120, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Bitencourt+NV%22">Bitencourt NV</searchLink>; Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara 14800-060, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Sanches+PRS%22">Sanches PRS</searchLink>; Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara 14800-060, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Santos-Filho+NA%22">Santos-Filho NA</searchLink>; Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara 14800-060, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Gawriljuk+VO%22">Gawriljuk VO</searchLink>; São Carlos Institute of Physics, University of Sao Paulo, Avenida João Dagnone, 1100, São Carlos 13563-120, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Souza+EP%22">de Souza EP</searchLink>; Department of Genetics and Evolution, Federal University of São Carlos, Rodovia Washington Luís km 235, São Carlos 13565-905, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Nogueira+VHR%22">Nogueira VHR</searchLink>; São Carlos Institute of Physics, University of Sao Paulo, Avenida João Dagnone, 1100, São Carlos 13563-120, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Godoy+MO%22">de Godoy MO</searchLink>; São Carlos Institute of Physics, University of Sao Paulo, Avenida João Dagnone, 1100, São Carlos 13563-120, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Nakamura+AM%22">Nakamura AM</searchLink>; São Carlos Institute of Physics, University of Sao Paulo, Avenida João Dagnone, 1100, São Carlos 13563-120, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Fernandes+RS%22">Fernandes RS</searchLink>; São Carlos Institute of Physics, University of Sao Paulo, Avenida João Dagnone, 1100, São Carlos 13563-120, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Godoy+AS%22">Godoy AS</searchLink>; São Carlos Institute of Physics, University of Sao Paulo, Avenida João Dagnone, 1100, São Carlos 13563-120, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Juliano+MA%22">Juliano MA</searchLink>; The Sao Paulo School of Medicine, Federal University of São Paulo, Rua Três de Maio, 100, São Paulo 04044-020, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Peres+BM%22">Peres BM</searchLink>; Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes, 1374, São Paulo 05508-900, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Barbosa+CG%22">Barbosa CG</searchLink>; Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes, 1374, São Paulo 05508-900, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Moraes+CB%22">Moraes CB</searchLink>; Department of Pharmaceutical Sciences, Federal University of São Paulo, Rua São Nicolau, 210, Diadema 09913-030, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Freitas-Junior+LHG%22">Freitas-Junior LHG</searchLink>; Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes, 1374, São Paulo 05508-900, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Cilli+EM%22">Cilli EM</searchLink>; Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara 14800-060, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Guido+RVC%22">Guido RVC</searchLink>; São Carlos Institute of Physics, University of Sao Paulo, Avenida João Dagnone, 1100, São Carlos 13563-120, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Oliva+G%22">Oliva G</searchLink>; São Carlos Institute of Physics, University of Sao Paulo, Avenida João Dagnone, 1100, São Carlos 13563-120, SP, Brazil.
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  Data: <searchLink fieldCode="JN" term="%22100964009%22">Molecules (Basel, Switzerland)</searchLink> [Molecules] 2021 Aug 12; Vol. 26 (16). <i>Date of Electronic Publication: </i>2021 Aug 12.
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