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ω-Functionalized Lipid Prodrugs of HIV NtRTI Tenofovir with Enhanced Pharmacokinetic Properties.

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Title: ω-Functionalized Lipid Prodrugs of HIV NtRTI Tenofovir with Enhanced Pharmacokinetic Properties.
Authors: Pribut N; Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States., D'Erasmo M; Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States., Dasari M; Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States., Giesler KE; Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States., Iskandar S; Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States., Sharma SK; Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States., Bartsch PW; Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States., Raghuram A; Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States., Bushnev A; Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States., Hwang SS; Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States., Burton SL; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, United States.; Emory Vaccine Center, Emory University, Atlanta, Georgia 30322, United States., Derdeyn CA; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, United States.; Emory Vaccine Center, Emory University, Atlanta, Georgia 30322, United States.; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, United States., Basson AE; HIV Pathogenesis Research Unit, Department of Molecular Medicine and Haematology, University of the Witwatersrand, Johannesburg, Gauteng 2193, South Africa., Liotta DC; Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States., Miller EJ; Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2021 Sep 09; Vol. 64 (17), pp. 12917-12937. Date of Electronic Publication: 2021 Aug 30.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
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  Data: ω-Functionalized Lipid Prodrugs of HIV NtRTI Tenofovir with Enhanced Pharmacokinetic Properties.
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  Data: <searchLink fieldCode="AU" term="%22Pribut+N%22">Pribut N</searchLink>; Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22D'Erasmo+M%22">D'Erasmo M</searchLink>; Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22Dasari+M%22">Dasari M</searchLink>; Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22Giesler+KE%22">Giesler KE</searchLink>; Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22Iskandar+S%22">Iskandar S</searchLink>; Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22Sharma+SK%22">Sharma SK</searchLink>; Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22Bartsch+PW%22">Bartsch PW</searchLink>; Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22Raghuram+A%22">Raghuram A</searchLink>; Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22Bushnev+A%22">Bushnev A</searchLink>; Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22Hwang+SS%22">Hwang SS</searchLink>; Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22Burton+SL%22">Burton SL</searchLink>; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, United States.; Emory Vaccine Center, Emory University, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22Derdeyn+CA%22">Derdeyn CA</searchLink>; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, United States.; Emory Vaccine Center, Emory University, Atlanta, Georgia 30322, United States.; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22Basson+AE%22">Basson AE</searchLink>; HIV Pathogenesis Research Unit, Department of Molecular Medicine and Haematology, University of the Witwatersrand, Johannesburg, Gauteng 2193, South Africa.<br /><searchLink fieldCode="AU" term="%22Liotta+DC%22">Liotta DC</searchLink>; Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22Miller+EJ%22">Miller EJ</searchLink>; Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2021 Sep 09; Vol. 64 (17), pp. 12917-12937. <i>Date of Electronic Publication: </i>2021 Aug 30.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1021/acs.jmedchem.1c01083
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              Text: 2021 Sep 09
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