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Conformational control of Cas9 by CRISPR hybrid RNA-DNA guides mitigates off-target activity in T cells.

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Title: Conformational control of Cas9 by CRISPR hybrid RNA-DNA guides mitigates off-target activity in T cells.
Authors: Donohoue PD; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA. Electronic address: donohoue@cariboubio.com., Pacesa M; Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland., Lau E; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA., Vidal B; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA., Irby MJ; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA., Nyer DB; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA., Rotstein T; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA., Banh L; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA., Toh MS; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA., Gibson J; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA., Kohrs B; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA., Baek K; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA., Owen ALG; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA., Slorach EM; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA., van Overbeek M; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA., Fuller CK; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA., May AP; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA. Electronic address: apmay1@gmail.com., Jinek M; Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. Electronic address: jinek@bioc.uzh.ch., Cameron P; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA. Electronic address: pscameron@gmail.com.
Source: Molecular cell [Mol Cell] 2021 Sep 02; Vol. 81 (17), pp. 3637-3649.e5.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Conformational control of Cas9 by CRISPR hybrid RNA-DNA guides mitigates off-target activity in T cells.
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  Data: <searchLink fieldCode="AU" term="%22Donohoue+PD%22">Donohoue PD</searchLink>; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA. Electronic address: donohoue@cariboubio.com.<br /><searchLink fieldCode="AU" term="%22Pacesa+M%22">Pacesa M</searchLink>; Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Lau+E%22">Lau E</searchLink>; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA.<br /><searchLink fieldCode="AU" term="%22Vidal+B%22">Vidal B</searchLink>; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA.<br /><searchLink fieldCode="AU" term="%22Irby+MJ%22">Irby MJ</searchLink>; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA.<br /><searchLink fieldCode="AU" term="%22Nyer+DB%22">Nyer DB</searchLink>; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA.<br /><searchLink fieldCode="AU" term="%22Rotstein+T%22">Rotstein T</searchLink>; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA.<br /><searchLink fieldCode="AU" term="%22Banh+L%22">Banh L</searchLink>; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA.<br /><searchLink fieldCode="AU" term="%22Toh+MS%22">Toh MS</searchLink>; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA.<br /><searchLink fieldCode="AU" term="%22Gibson+J%22">Gibson J</searchLink>; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA.<br /><searchLink fieldCode="AU" term="%22Kohrs+B%22">Kohrs B</searchLink>; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA.<br /><searchLink fieldCode="AU" term="%22Baek+K%22">Baek K</searchLink>; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA.<br /><searchLink fieldCode="AU" term="%22Owen+ALG%22">Owen ALG</searchLink>; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA.<br /><searchLink fieldCode="AU" term="%22Slorach+EM%22">Slorach EM</searchLink>; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA.<br /><searchLink fieldCode="AU" term="%22van+Overbeek+M%22">van Overbeek M</searchLink>; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA.<br /><searchLink fieldCode="AU" term="%22Fuller+CK%22">Fuller CK</searchLink>; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA.<br /><searchLink fieldCode="AU" term="%22May+AP%22">May AP</searchLink>; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA. Electronic address: apmay1@gmail.com.<br /><searchLink fieldCode="AU" term="%22Jinek+M%22">Jinek M</searchLink>; Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. Electronic address: jinek@bioc.uzh.ch.<br /><searchLink fieldCode="AU" term="%22Cameron+P%22">Cameron P</searchLink>; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA. Electronic address: pscameron@gmail.com.
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  Data: <searchLink fieldCode="JN" term="%229802571%22">Molecular cell</searchLink> [Mol Cell] 2021 Sep 02; Vol. 81 (17), pp. 3637-3649.e5.
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