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The potent and selective RIPK2 inhibitor BI 706039 improves intestinal inflammation in the TRUC mouse model of inflammatory bowel disease.

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Title: The potent and selective RIPK2 inhibitor BI 706039 improves intestinal inflammation in the TRUC mouse model of inflammatory bowel disease.
Authors: Ermann J; Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts., Matmusaev M; Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Boston, Massachusetts., Haley EK; Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Boston, Massachusetts., Braun C; Department of Drug Discovery Sciences, Boehringer-Ingelheim Pharmaceuticals Incorporated, Biberach, Germany., Jost F; Department of Drug Discovery Sciences, Boehringer-Ingelheim Pharmaceuticals Incorporated, Biberach, Germany., Mayer-Wrangowski S; Department of Drug Discovery Sciences, Boehringer-Ingelheim Pharmaceuticals Incorporated, Biberach, Germany., Hsiao P; Department of Drug Discovery Sciences, Boehringer-Ingelheim Pharmaceuticals Incorporated, Biberach, Germany., Ting N; Department of Global Computational Biology and Data Sciences, Boehringer-Ingelheim Pharmaceuticals Incorporated, Ridgefield, Connecticut., Li L; Department of Global Computational Biology and Data Sciences, Boehringer-Ingelheim Pharmaceuticals Incorporated, Ridgefield, Connecticut., Terenzio D; Department of Immunology and Respiratory Diseases Research, Boehringer-Ingelheim Pharmaceuticals Incorporated, Ridgefield, Connecticut., Chime J; Department of Immunology and Respiratory Diseases Research, Boehringer-Ingelheim Pharmaceuticals Incorporated, Ridgefield, Connecticut., Lukas S; Department of Immunology and Respiratory Diseases Research, Boehringer-Ingelheim Pharmaceuticals Incorporated, Ridgefield, Connecticut., Patnaude L; Department of Immunology and Respiratory Diseases Research, Boehringer-Ingelheim Pharmaceuticals Incorporated, Ridgefield, Connecticut., Panzenbeck M; Department of Immunology and Respiratory Diseases Research, Boehringer-Ingelheim Pharmaceuticals Incorporated, Ridgefield, Connecticut., Csordas D; Department of Immunology and Respiratory Diseases Research, Boehringer-Ingelheim Pharmaceuticals Incorporated, Ridgefield, Connecticut., Zheng J; Department of Immunology and Respiratory Diseases Research, Boehringer-Ingelheim Pharmaceuticals Incorporated, Ridgefield, Connecticut., Mierz D; Department of Immunology and Respiratory Diseases Research, Boehringer-Ingelheim Pharmaceuticals Incorporated, Ridgefield, Connecticut., Simpson T; Department of Immunology and Respiratory Diseases Research, Boehringer-Ingelheim Pharmaceuticals Incorporated, Ridgefield, Connecticut., King FJ; Department of Immunology and Respiratory Diseases Research, Boehringer-Ingelheim Pharmaceuticals Incorporated, Ridgefield, Connecticut., Klimowicz AP; Department of Immunology and Respiratory Diseases Research, Boehringer-Ingelheim Pharmaceuticals Incorporated, Ridgefield, Connecticut., Mbow ML; Department of Immunology and Respiratory Diseases Research, Boehringer-Ingelheim Pharmaceuticals Incorporated, Ridgefield, Connecticut., Fine JS; Department of Immunology and Respiratory Diseases Research, Boehringer-Ingelheim Pharmaceuticals Incorporated, Ridgefield, Connecticut., Miller CA; Department of Immunology and Respiratory Diseases Research, Boehringer-Ingelheim Pharmaceuticals Incorporated, Ridgefield, Connecticut., Fogal SE; Department of Immunology and Respiratory Diseases Research, Boehringer-Ingelheim Pharmaceuticals Incorporated, Ridgefield, Connecticut., Byrne FR; Department of Immunology and Respiratory Diseases Research, Boehringer-Ingelheim Pharmaceuticals Incorporated, Ridgefield, Connecticut.
Source: American journal of physiology. Gastrointestinal and liver physiology [Am J Physiol Gastrointest Liver Physiol] 2021 Nov 01; Vol. 321 (5), pp. G500-G512. Date of Electronic Publication: 2021 Sep 08.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901227 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1547 (Electronic) Linking ISSN: 01931857 NLM ISO Abbreviation: Am J Physiol Gastrointest Liver Physiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The potent and selective RIPK2 inhibitor BI 706039 improves intestinal inflammation in the TRUC mouse model of inflammatory bowel disease.
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  Data: <searchLink fieldCode="AU" term="%22Ermann+J%22">Ermann J</searchLink>; Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Matmusaev+M%22">Matmusaev M</searchLink>; Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Haley+EK%22">Haley EK</searchLink>; Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Braun+C%22">Braun C</searchLink>; Department of Drug Discovery Sciences, Boehringer-Ingelheim Pharmaceuticals Incorporated, Biberach, Germany.<br /><searchLink fieldCode="AU" term="%22Jost+F%22">Jost F</searchLink>; Department of Drug Discovery Sciences, Boehringer-Ingelheim Pharmaceuticals Incorporated, Biberach, Germany.<br /><searchLink fieldCode="AU" term="%22Mayer-Wrangowski+S%22">Mayer-Wrangowski S</searchLink>; Department of Drug Discovery Sciences, Boehringer-Ingelheim Pharmaceuticals Incorporated, Biberach, Germany.<br /><searchLink fieldCode="AU" term="%22Hsiao+P%22">Hsiao P</searchLink>; Department of Drug Discovery Sciences, Boehringer-Ingelheim Pharmaceuticals Incorporated, Biberach, Germany.<br /><searchLink fieldCode="AU" term="%22Ting+N%22">Ting N</searchLink>; Department of Global Computational Biology and Data Sciences, Boehringer-Ingelheim Pharmaceuticals Incorporated, Ridgefield, Connecticut.<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; Department of Global Computational Biology and Data Sciences, Boehringer-Ingelheim Pharmaceuticals Incorporated, Ridgefield, Connecticut.<br /><searchLink fieldCode="AU" term="%22Terenzio+D%22">Terenzio D</searchLink>; Department of Immunology and Respiratory Diseases Research, Boehringer-Ingelheim Pharmaceuticals Incorporated, Ridgefield, Connecticut.<br /><searchLink fieldCode="AU" term="%22Chime+J%22">Chime J</searchLink>; Department of Immunology and Respiratory Diseases Research, Boehringer-Ingelheim Pharmaceuticals Incorporated, Ridgefield, Connecticut.<br /><searchLink fieldCode="AU" term="%22Lukas+S%22">Lukas S</searchLink>; Department of Immunology and Respiratory Diseases Research, Boehringer-Ingelheim Pharmaceuticals Incorporated, Ridgefield, Connecticut.<br /><searchLink fieldCode="AU" term="%22Patnaude+L%22">Patnaude L</searchLink>; Department of Immunology and Respiratory Diseases Research, Boehringer-Ingelheim Pharmaceuticals Incorporated, Ridgefield, Connecticut.<br /><searchLink fieldCode="AU" term="%22Panzenbeck+M%22">Panzenbeck M</searchLink>; Department of Immunology and Respiratory Diseases Research, Boehringer-Ingelheim Pharmaceuticals Incorporated, Ridgefield, Connecticut.<br /><searchLink fieldCode="AU" term="%22Csordas+D%22">Csordas D</searchLink>; Department of Immunology and Respiratory Diseases Research, Boehringer-Ingelheim Pharmaceuticals Incorporated, Ridgefield, Connecticut.<br /><searchLink fieldCode="AU" term="%22Zheng+J%22">Zheng J</searchLink>; Department of Immunology and Respiratory Diseases Research, Boehringer-Ingelheim Pharmaceuticals Incorporated, Ridgefield, Connecticut.<br /><searchLink fieldCode="AU" term="%22Mierz+D%22">Mierz D</searchLink>; Department of Immunology and Respiratory Diseases Research, Boehringer-Ingelheim Pharmaceuticals Incorporated, Ridgefield, Connecticut.<br /><searchLink fieldCode="AU" term="%22Simpson+T%22">Simpson T</searchLink>; Department of Immunology and Respiratory Diseases Research, Boehringer-Ingelheim Pharmaceuticals Incorporated, Ridgefield, Connecticut.<br /><searchLink fieldCode="AU" term="%22King+FJ%22">King FJ</searchLink>; Department of Immunology and Respiratory Diseases Research, Boehringer-Ingelheim Pharmaceuticals Incorporated, Ridgefield, Connecticut.<br /><searchLink fieldCode="AU" term="%22Klimowicz+AP%22">Klimowicz AP</searchLink>; Department of Immunology and Respiratory Diseases Research, Boehringer-Ingelheim Pharmaceuticals Incorporated, Ridgefield, Connecticut.<br /><searchLink fieldCode="AU" term="%22Mbow+ML%22">Mbow ML</searchLink>; Department of Immunology and Respiratory Diseases Research, Boehringer-Ingelheim Pharmaceuticals Incorporated, Ridgefield, Connecticut.<br /><searchLink fieldCode="AU" term="%22Fine+JS%22">Fine JS</searchLink>; Department of Immunology and Respiratory Diseases Research, Boehringer-Ingelheim Pharmaceuticals Incorporated, Ridgefield, Connecticut.<br /><searchLink fieldCode="AU" term="%22Miller+CA%22">Miller CA</searchLink>; Department of Immunology and Respiratory Diseases Research, Boehringer-Ingelheim Pharmaceuticals Incorporated, Ridgefield, Connecticut.<br /><searchLink fieldCode="AU" term="%22Fogal+SE%22">Fogal SE</searchLink>; Department of Immunology and Respiratory Diseases Research, Boehringer-Ingelheim Pharmaceuticals Incorporated, Ridgefield, Connecticut.<br /><searchLink fieldCode="AU" term="%22Byrne+FR%22">Byrne FR</searchLink>; Department of Immunology and Respiratory Diseases Research, Boehringer-Ingelheim Pharmaceuticals Incorporated, Ridgefield, Connecticut.
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  Data: <searchLink fieldCode="JN" term="%22100901227%22">American journal of physiology. Gastrointestinal and liver physiology</searchLink> [Am J Physiol Gastrointest Liver Physiol] 2021 Nov 01; Vol. 321 (5), pp. G500-G512. <i>Date of Electronic Publication: </i>2021 Sep 08.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Physiological+Society%22">American Physiological Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100901227 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1522-1547 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201931857%22">01931857 </searchLink><i>NLM ISO Abbreviation: </i>Am J Physiol Gastrointest Liver Physiol <i>Subsets: </i>MEDLINE
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