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Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression.

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Title: Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression.
Authors: Yun H; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Department of Medicine V, Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany., Narayan N; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Vohra S; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Giotopoulos G; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Mupo A; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Haematological Cancer Genetics, Wellcome Sanger Institute, Cambridge, UK.; Epigenetics Programme, The Babraham Institute, Cambridge, UK., Madrigal P; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Sasca D; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Department of Hematology, Oncology and Pneumology, University Medical Center Mainz, Mainz, Germany., Lara-Astiaso D; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Horton SJ; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Agrawal-Singh S; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Meduri E; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Basheer F; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Marando L; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Gozdecka M; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Haematological Cancer Genetics, Wellcome Sanger Institute, Cambridge, UK., Dovey OM; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Haematological Cancer Genetics, Wellcome Sanger Institute, Cambridge, UK., Castillo-Venzor A; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK., Wang X; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Gallipoli P; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK., Müller-Tidow C; Department of Medicine V, Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany., Osborne CS; Department of Medical and Molecular Genetics, King's College London, London, UK., Vassiliou GS; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Haematological Cancer Genetics, Wellcome Sanger Institute, Cambridge, UK., Huntly BJP; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK. bjph2@cam.ac.uk.; Department of Haematology, University of Cambridge, Cambridge, UK. bjph2@cam.ac.uk.
Source: Nature genetics [Nat Genet] 2021 Oct; Vol. 53 (10), pp. 1443-1455. Date of Electronic Publication: 2021 Sep 23.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
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  Data: Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression.
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  Data: <searchLink fieldCode="AU" term="%22Yun+H%22">Yun H</searchLink>; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Department of Medicine V, Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Narayan+N%22">Narayan N</searchLink>; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Vohra+S%22">Vohra S</searchLink>; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Giotopoulos+G%22">Giotopoulos G</searchLink>; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Mupo+A%22">Mupo A</searchLink>; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Haematological Cancer Genetics, Wellcome Sanger Institute, Cambridge, UK.; Epigenetics Programme, The Babraham Institute, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Madrigal+P%22">Madrigal P</searchLink>; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Sasca+D%22">Sasca D</searchLink>; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Department of Hematology, Oncology and Pneumology, University Medical Center Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Lara-Astiaso+D%22">Lara-Astiaso D</searchLink>; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Horton+SJ%22">Horton SJ</searchLink>; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Agrawal-Singh+S%22">Agrawal-Singh S</searchLink>; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Meduri+E%22">Meduri E</searchLink>; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Basheer+F%22">Basheer F</searchLink>; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Marando+L%22">Marando L</searchLink>; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Gozdecka+M%22">Gozdecka M</searchLink>; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Haematological Cancer Genetics, Wellcome Sanger Institute, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Dovey+OM%22">Dovey OM</searchLink>; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Haematological Cancer Genetics, Wellcome Sanger Institute, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Castillo-Venzor+A%22">Castillo-Venzor A</searchLink>; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Gallipoli+P%22">Gallipoli P</searchLink>; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Müller-Tidow+C%22">Müller-Tidow C</searchLink>; Department of Medicine V, Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Osborne+CS%22">Osborne CS</searchLink>; Department of Medical and Molecular Genetics, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Vassiliou+GS%22">Vassiliou GS</searchLink>; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Haematological Cancer Genetics, Wellcome Sanger Institute, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Huntly+BJP%22">Huntly BJP</searchLink>; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK. bjph2@cam.ac.uk.; Department of Haematology, University of Cambridge, Cambridge, UK. bjph2@cam.ac.uk.
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