Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression.
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| Title: | Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression. |
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| Authors: | Yun H; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Department of Medicine V, Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany., Narayan N; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Vohra S; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Giotopoulos G; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Mupo A; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Haematological Cancer Genetics, Wellcome Sanger Institute, Cambridge, UK.; Epigenetics Programme, The Babraham Institute, Cambridge, UK., Madrigal P; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Sasca D; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Department of Hematology, Oncology and Pneumology, University Medical Center Mainz, Mainz, Germany., Lara-Astiaso D; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Horton SJ; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Agrawal-Singh S; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Meduri E; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Basheer F; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Marando L; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Gozdecka M; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Haematological Cancer Genetics, Wellcome Sanger Institute, Cambridge, UK., Dovey OM; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Haematological Cancer Genetics, Wellcome Sanger Institute, Cambridge, UK., Castillo-Venzor A; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK., Wang X; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Gallipoli P; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK., Müller-Tidow C; Department of Medicine V, Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany., Osborne CS; Department of Medical and Molecular Genetics, King's College London, London, UK., Vassiliou GS; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Haematological Cancer Genetics, Wellcome Sanger Institute, Cambridge, UK., Huntly BJP; Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK. bjph2@cam.ac.uk.; Department of Haematology, University of Cambridge, Cambridge, UK. bjph2@cam.ac.uk. |
| Source: | Nature genetics [Nat Genet] 2021 Oct; Vol. 53 (10), pp. 1443-1455. Date of Electronic Publication: 2021 Sep 23. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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