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In vivo inducible reverse genetics in patients' tumors to identify individual therapeutic targets.

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Title: In vivo inducible reverse genetics in patients' tumors to identify individual therapeutic targets.
Authors: Carlet M; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany., Völse K; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany., Vergalli J; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany., Becker M; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany., Herold T; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany.; Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, LMU Munich, Munich, Germany.; German Cancer Consortium (DKTK), Partnering Site Munich, Munich, Germany., Arner A; Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, Ludwig Maximilian University (LMU), Munich, Germany., Senft D; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany., Jurinovic V; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany.; Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, LMU Munich, Munich, Germany.; Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, Ludwig Maximilian University (LMU), Munich, Germany., Liu WH; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany., Gao Y; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany., Dill V; Clinic and Policlinic for Internal Medicine III, Technical University of Munich, School of Medicine, Munich, Germany., Fehse B; Research Department Cell and Gene Therapy, Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Baldus CD; Internal Medicine II, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany., Bastian L; Internal Medicine II, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany., Lenk L; Department of Pediatrics I, ALL-BFM Study Group, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany., Schewe DM; Department of Pediatrics I, ALL-BFM Study Group, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany., Bagnoli JW; Anthropology and Human Genomics, Faculty of Biology, Ludwig Maximilian University (LMU), Munich, Germany., Vick B; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany.; German Cancer Consortium (DKTK), Partnering Site Munich, Munich, Germany., Schmid JP; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany., Wilhelm A; Institute of Pharmaceutical Biology, Diagnosic Center of Acute Leukemias (DCAL), Goethe-University, Frankfurt/Main, Germany., Marschalek R; Institute of Pharmaceutical Biology, Diagnosic Center of Acute Leukemias (DCAL), Goethe-University, Frankfurt/Main, Germany., Jost PJ; German Cancer Consortium (DKTK), Partnering Site Munich, Munich, Germany.; Clinic and Policlinic for Internal Medicine III, Technical University of Munich, School of Medicine, Munich, Germany.; Center for Translational Cancer Research (TranslaTUM), Klinikum rechts der Isar, Technical University of Munich, Munich, Germany., Miething C; Department of Medicine I, Medical Center, University of Freiburg, Faculty of Medicine, Freiburg, Germany.; German Cancer Consortium (DKTK), Partnering Site Freiburg, Freiburg, Germany., Riecken K; Research Department Cell and Gene Therapy, Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Schmidt-Supprian M; Institute of Experimental Hematology, Technical University of Munich, Munich, Germany., Binder V; Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, Ludwig Maximilian University (LMU), Munich, Germany., Jeremias I; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany. Irmela.Jeremias@helmholtz-muenchen.de.; German Cancer Consortium (DKTK), Partnering Site Munich, Munich, Germany. Irmela.Jeremias@helmholtz-muenchen.de.; Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, Ludwig Maximilian University (LMU), Munich, Germany. Irmela.Jeremias@helmholtz-muenchen.de.
Source: Nature communications [Nat Commun] 2021 Sep 27; Vol. 12 (1), pp. 5655. Date of Electronic Publication: 2021 Sep 27.
Publication Type: Journal Article; Observational Study; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-021-25963-z