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DNA hypomethylation leads to cGAS-induced autoinflammation in the epidermis.

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Title: DNA hypomethylation leads to cGAS-induced autoinflammation in the epidermis.
Authors: Beck MA; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria., Fischer H; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria., Grabner LM; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria., Groffics T; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria., Winter M; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria., Tangermann S; Unit of Laboratory Animal Pathology, University of Veterinary Medicine, Vienna, Austria., Meischel T; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria., Zaussinger-Haas B; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria., Wagner P; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria., Fischer C; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria., Folie C; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria.; Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Salzburg, Austria., Arand J; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria., Schöfer C; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria., Ramsahoye B; MRC Institute of Genetics & Molecular Medicine, Centre for Genomic & Experimental Medicine, University of Edinburgh, Edinburgh, UK., Lagger S; Unit of Laboratory Animal Pathology, University of Veterinary Medicine, Vienna, Austria., Machat G; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria., Eisenwort G; Institute of Immunology, Medical University of Vienna, Vienna, Austria., Schneider S; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria., Podhornik A; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria., Kothmayer M; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria., Reichart U; VetCORE - Facility for Research, University of Veterinary Medicine Vienna, Vienna, Austria., Glösmann M; VetCORE - Facility for Research, University of Veterinary Medicine Vienna, Vienna, Austria., Tamir I; Campus Science Support Facilities GmbH, Vienna, Austria., Mildner M; Research Division of Biology and Pathobiology of the Skin, Medical University of Vienna, Vienna, Austria., Sheibani-Tezerji R; Ludwig Boltzmann Institute Applied Diagnostics, Vienna, Austria., Kenner L; Unit of Laboratory Animal Pathology, University of Veterinary Medicine, Vienna, Austria.; Christian Doppler Laboratory for Applied Metabolomics, Vienna, Austria.; Department of Pathology, Medical University of Vienna, Vienna, Austria.; CBmed GmbH - Center for Biomarker Research in Medicine, Graz, Austria., Petzelbauer P; Skin and Endothelium Research Division, Department of Dermatology, Medical University of Vienna, Vienna, Austria., Egger G; Ludwig Boltzmann Institute Applied Diagnostics, Vienna, Austria.; Department of Pathology, Medical University of Vienna, Vienna, Austria., Sibilia M; Department of Medicine I, Comprehensive Cancer Center, Institute of Cancer Research, Medical University of Vienna), Vienna, Austria., Ablasser A; Global Health Institute, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland., Seiser C; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria.
Source: The EMBO journal [EMBO J] 2021 Nov 15; Vol. 40 (22), pp. e108234. Date of Electronic Publication: 2021 Sep 29.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
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  Data: DNA hypomethylation leads to cGAS-induced autoinflammation in the epidermis.
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