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Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial.

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Title: Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial.
Authors: Estcourt LJ; NHS Blood and Transplant, Oxford, England.; Radcliffe Department of Medicine and BRC Hematology Theme, University of Oxford, Oxford, England., Turgeon AF; Division of Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Université Laval, Quebec City, Quebec, Canada.; CHU de Québec-Université Laval Research Center, Population Health and Optimal Health Practices Unit, Trauma-Emergency-Critical Care Medicine, CHU de Québec-Université Laval, Quebec City, Quebec, Canada., McQuilten ZK; Transfusion Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.; Department of Clinical Hematology, Monash Health, Melbourne, Australia., McVerry BJ; Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania., Al-Beidh F; Division of Anesthetics, Pain Medicine, and Intensive Care Medicine, Department of Surgery and Cancer, Imperial College London and Imperial College Healthcare NHS Trust, London, England., Annane D; Intensive Care Unit, Raymond Poincaré Hospital, Paris, France.; Simone Veil School of Medicine, University of Versailles, Versailles, France.; University Paris Saclay, Garches, France., Arabi YM; Intensive Care Department, College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia., Arnold DM; McMaster University, Hamilton, Ontario, Canada., Beane A; Nuffield Department of Clinical Medicine, University of Oxford, Oxford, England., Bégin P; Université de Montréal, Montreal, Quebec, Canada., van Bentum-Puijk W; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Berry LR; Berry Consultants LLC, Austin, Texas., Bhimani Z; Li Ka Shing Knowledge Institute, Unity Health Toronto, St Michael's Hospital, Toronto, Ontario, Canada., Birchall JE; Welsh Blood Service, Cardiff, Wales., Bonten MJM; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Bradbury CA; University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, England.; Faculty of Health Sciences, University of Bristol, Bristol, England., Brunkhorst FM; Center for Clinical Studies and Center for Sepsis Control and Care, Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany., Buxton M; Global Coalition for Adaptive Research, San Francisco, California., Callum JL; Canadian Blood Services, Ottawa, Ontario, Canada.; Department of Pathology and Molecular Medicine, Kingston Health Sciences Centre and Queens University, Kingston, Ontario, Canada.; Department of Laboratory Medicine and Molecular Diagnostics, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada., Chassé M; Université de Montréal, Montreal, Quebec, Canada., Cheng AC; Infection Prevention and Healthcare Epidemiology Unit, Alfred Health, Melbourne, Australia.; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia., Cove ME; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Daly J; Australian Red Cross Lifeblood, Sydney and Perth, Australia., Derde L; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.; Intensive Care Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Detry MA; Berry Consultants LLC, Austin, Texas., De Jong M; Department of Medical Microbiology, University of Amsterdam Medical Center, University of Amsterdam, the Netherlands., Evans A; NHSBT Clinical Trials Unit, NHS Blood and Transplant, Cambridge, England., Fergusson DA; Ottawa Hospital Research Institute, Clinical Epidemiology Unit, Ottawa, Ontario, Canada., Fish M; School of Immunology and Microbial Sciences, Kings College London, London, England., Fitzgerald M; Berry Consultants LLC, Austin, Texas., Foley C; NHSBT Clinical Trials Unit, NHS Blood and Transplant, Cambridge, England., Goossens H; Department of Microbiology, Antwerp University Hospital, Antwerp, Belgium., Gordon AC; Division of Anesthetics, Pain Medicine, and Intensive Care Medicine, Department of Surgery and Cancer, Imperial College London and Imperial College Healthcare NHS Trust, London, England., Gosbell IB; Australian Red Cross Lifeblood, Sydney and Perth, Australia.; Western Sydney University, Sydney, Australia., Green C; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia., Haniffa R; Network for Improving Critical Care Systems and Training, Colombo, Sri Lanka.; Mahidol Oxford Tropical Medicine Research Unit, Bangkok, Thailand., Harvala H; NHS Blood and Transplant, London, England., Higgins AM; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia., Hills TE; Medical Research Institute of New Zealand, Wellington., Hoad VC; Australian Red Cross Lifeblood, Sydney and Perth, Australia., Horvat C; UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania., Huang DT; Department of Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania., Hudson CL; NHSBT Clinical Trials Unit, Bristol, England., Ichihara N; Department of Healthcare Quality Assessment, Graduate School of Medicine, University of Tokyo, Tokyo, Japan., Laing E; NHSBT Clinical Trials Unit, NHS Blood and Transplant, Cambridge, England., Lamikanra AA; NHS Blood and Transplant, Oxford, England., Lamontagne F; Université de Sherbrooke, Sherbrooke, Quebec, Canada., Lawler PR; Cardiac Intensive Care Unit, Peter Munk Cardiac Centre, University Health Network, Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada., Linstrum K; Clinical Research Investigation and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania., Litton E; School of Medicine and Pharmacology, University of Western Australia, Crawley., Lorenzi E; Berry Consultants LLC, Austin, Texas., MacLennan S; NHS Blood and Transplant, Barnsley, England., Marshall J; Li Ka Shing Knowledge Institute, Unity Health Toronto, St Michael's Hospital, Toronto, Ontario, Canada.; Interdepartmental Division of Critical Care, University of Toronto, Toronto, Ontario, Canada., McAuley DF; Centre for Experimental Medicine, School of Medicine, Dentistry, and Biomedical Sciences, Queen's University Belfast, Belfast, Ireland., McDyer JF; Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania., McGlothlin A; Berry Consultants LLC, Austin, Texas., McGuinness S; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.; Cardiothoracic and Vascular Intensive Care Unit, Auckland City Hospital, Auckland, New Zealand.; Medical Research Institute of New Zealand, Wellington., Miflin G; NHS Blood and Transplant, Bristol, England., Montgomery S; Clinical Research Investigation and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.; UPMC Health System Office of Healthcare Innovation, Pittsburgh, Pennsylvania., Mouncey PR; Clinical Trials Unit, Intensive Care National Audit and Research Centre, London, England., Murthy S; School of Medicine, University of British Columbia, Vancouver, Canada., Nichol A; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.; Department of Anesthesia and Intensive Care, St Vincent's University Hospital, Dublin, Ireland.; School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland.; Department of Intensive Care, Alfred Health, Melbourne, Australia., Parke R; Cardiothoracic and Vascular Intensive Care Unit, Auckland City Hospital, Auckland, New Zealand.; Medical Research Institute of New Zealand, Wellington.; School of Nursing, University of Auckland, Auckland, New Zealand., Parker JC; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia., Priddee N; Scottish National Blood Transfusion Service, Edinburgh, Scotland., Purcell DFJ; Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia., Reyes LF; Universidad de La Sabana, Chia, Colombia.; Clinica Universidad de La Sabana, Chia, Colombia., Richardson P; Welsh Blood Service, Cardiff, Wales., Robitaille N; Héma-Québec, Montreal, Quebec, Canada.; Division of Hematology and Oncology, Department of Pediatrics, CHU Sainte-Justine, Montreal, Quebec, Canada.; Department of Pediatrics, Université de Montréal, Montreal, Quebec, Canada., Rowan KM; Clinical Trials Unit, Intensive Care National Audit and Research Centre, London, England., Rynne J; School of Immunology and Microbial Sciences, Kings College London, London, England., Saito H; Department of Emergency and Critical Care Medicine, St Marianna University School of Medicine, Yokohama City Seibu Hospital, Yokohama, Japan., Santos M; Li Ka Shing Knowledge Institute, Unity Health Toronto, St Michael's Hospital, Toronto, Ontario, Canada., Saunders CT; Berry Consultants LLC, Austin, Texas., Serpa Neto A; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.; Department of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil., Seymour CW; Clinical Research Investigation and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.; UPMC Health System Office of Healthcare Innovation, Pittsburgh, Pennsylvania., Silversides JA; Centre for Experimental Medicine, School of Medicine, Dentistry, and Biomedical Sciences, Queen's University Belfast, Belfast, Ireland., Tinmouth AA; Ottawa Hospital Research Institute, Clinical Epidemiology Unit, Ottawa, Ontario, Canada., Triulzi DJ; Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania., Turner AM; Medical Research Institute of New Zealand, Wellington., van de Veerdonk F; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands., Walsh TS; University of Edinburgh, Edinburgh, Scotland., Wood EM; Transfusion Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.; Department of Clinical Hematology, Monash Health, Melbourne, Australia., Berry S; Berry Consultants LLC, Austin, Texas., Lewis RJ; Berry Consultants LLC, Austin, Texas.; Department of Emergency Medicine, Harbor-UCLA Medical Center, Torrance, California.; Department of Emergency Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California., Menon DK; University Division of Anesthesia, Addenbrooke's Hospital Cambridge, Cambridge, England., McArthur C; Clinical Trials Unit, Intensive Care National Audit and Research Centre, London, England.; Department of Critical Care Medicine, Auckland City Hospital, Auckland, New Zealand., Zarychanski R; Department of Medicine, Critical Care and Hematology/Medical Oncology, University of Manitoba, Winnipeg, Canada., Angus DC; Clinical Research Investigation and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.; UPMC Health System Office of Healthcare Innovation, Pittsburgh, Pennsylvania., Webb SA; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.; St John of God Hospital, Subiaco, Australia., Roberts DJ; NHS Blood and Transplant, Oxford, England.; Radcliffe Department of Medicine and BRC Hematology Theme, University of Oxford, Oxford, England., Shankar-Hari M; School of Immunology and Microbial Sciences, Kings College London, London, England.; Guy's and St Thomas' NHS Foundation Trust, ICU Support Offices, St Thomas' Hospital, London, England.
Corporate Authors: Writing Committee for the REMAP-CAP Investigators
Source: JAMA [JAMA] 2021 Nov 02; Vol. 326 (17), pp. 1690-1702.
Publication Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Adaptive Clinical Trial
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE
Database: MEDLINE Ultimate
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial.
– Name: Author
  Label: Authors
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Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bradbury+CA%22">Bradbury CA</searchLink>; University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, England.; Faculty of Health Sciences, University of Bristol, Bristol, England.<br /><searchLink fieldCode="AU" term="%22Brunkhorst+FM%22">Brunkhorst FM</searchLink>; Center for Clinical Studies and Center for Sepsis Control and Care, Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Buxton+M%22">Buxton M</searchLink>; Global Coalition for Adaptive Research, San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Callum+JL%22">Callum JL</searchLink>; Canadian Blood Services, Ottawa, Ontario, Canada.; Department of Pathology and Molecular Medicine, Kingston Health Sciences Centre and Queens University, Kingston, Ontario, Canada.; Department of Laboratory Medicine and Molecular Diagnostics, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Chassé+M%22">Chassé M</searchLink>; Université de Montréal, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Cheng+AC%22">Cheng AC</searchLink>; Infection Prevention and Healthcare Epidemiology Unit, Alfred Health, Melbourne, Australia.; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Cove+ME%22">Cove ME</searchLink>; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Daly+J%22">Daly J</searchLink>; Australian Red Cross Lifeblood, Sydney and Perth, Australia.<br /><searchLink fieldCode="AU" term="%22Derde+L%22">Derde L</searchLink>; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.; Intensive Care Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Detry+MA%22">Detry MA</searchLink>; Berry Consultants LLC, Austin, Texas.<br /><searchLink fieldCode="AU" term="%22De+Jong+M%22">De Jong M</searchLink>; Department of Medical Microbiology, University of Amsterdam Medical Center, University of Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Evans+A%22">Evans A</searchLink>; NHSBT Clinical Trials Unit, NHS Blood and Transplant, Cambridge, England.<br /><searchLink fieldCode="AU" term="%22Fergusson+DA%22">Fergusson DA</searchLink>; Ottawa Hospital Research Institute, Clinical Epidemiology Unit, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Fish+M%22">Fish M</searchLink>; School of Immunology and Microbial Sciences, Kings College London, London, England.<br /><searchLink fieldCode="AU" term="%22Fitzgerald+M%22">Fitzgerald M</searchLink>; Berry Consultants LLC, Austin, Texas.<br /><searchLink fieldCode="AU" term="%22Foley+C%22">Foley C</searchLink>; NHSBT Clinical Trials Unit, NHS Blood and Transplant, Cambridge, England.<br /><searchLink fieldCode="AU" term="%22Goossens+H%22">Goossens H</searchLink>; Department of Microbiology, Antwerp University Hospital, Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Gordon+AC%22">Gordon AC</searchLink>; Division of Anesthetics, Pain Medicine, and Intensive Care Medicine, Department of Surgery and Cancer, Imperial College London and Imperial College Healthcare NHS Trust, London, England.<br /><searchLink fieldCode="AU" term="%22Gosbell+IB%22">Gosbell IB</searchLink>; Australian Red Cross Lifeblood, Sydney and Perth, Australia.; Western Sydney University, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Green+C%22">Green C</searchLink>; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Haniffa+R%22">Haniffa R</searchLink>; Network for Improving Critical Care Systems and Training, Colombo, Sri Lanka.; Mahidol Oxford Tropical Medicine Research Unit, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Harvala+H%22">Harvala H</searchLink>; NHS Blood and Transplant, London, England.<br /><searchLink fieldCode="AU" term="%22Higgins+AM%22">Higgins AM</searchLink>; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Hills+TE%22">Hills TE</searchLink>; Medical Research Institute of New Zealand, Wellington.<br /><searchLink fieldCode="AU" term="%22Hoad+VC%22">Hoad VC</searchLink>; Australian Red Cross Lifeblood, Sydney and Perth, Australia.<br /><searchLink fieldCode="AU" term="%22Horvat+C%22">Horvat C</searchLink>; UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Huang+DT%22">Huang DT</searchLink>; Department of Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Hudson+CL%22">Hudson CL</searchLink>; NHSBT Clinical Trials Unit, Bristol, England.<br /><searchLink fieldCode="AU" term="%22Ichihara+N%22">Ichihara N</searchLink>; Department of Healthcare Quality Assessment, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Laing+E%22">Laing E</searchLink>; NHSBT Clinical Trials Unit, NHS Blood and Transplant, Cambridge, England.<br /><searchLink fieldCode="AU" term="%22Lamikanra+AA%22">Lamikanra AA</searchLink>; NHS Blood and Transplant, Oxford, England.<br /><searchLink fieldCode="AU" term="%22Lamontagne+F%22">Lamontagne F</searchLink>; Université de Sherbrooke, Sherbrooke, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Lawler+PR%22">Lawler PR</searchLink>; Cardiac Intensive Care Unit, Peter Munk Cardiac Centre, University Health Network, Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Linstrum+K%22">Linstrum K</searchLink>; Clinical Research Investigation and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Litton+E%22">Litton E</searchLink>; School of Medicine and Pharmacology, University of Western Australia, Crawley.<br /><searchLink fieldCode="AU" term="%22Lorenzi+E%22">Lorenzi E</searchLink>; Berry Consultants LLC, Austin, Texas.<br /><searchLink fieldCode="AU" term="%22MacLennan+S%22">MacLennan S</searchLink>; NHS Blood and Transplant, Barnsley, England.<br /><searchLink fieldCode="AU" term="%22Marshall+J%22">Marshall J</searchLink>; Li Ka Shing Knowledge Institute, Unity Health Toronto, St Michael's Hospital, Toronto, Ontario, Canada.; Interdepartmental Division of Critical Care, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22McAuley+DF%22">McAuley DF</searchLink>; Centre for Experimental Medicine, School of Medicine, Dentistry, and Biomedical Sciences, Queen's University Belfast, Belfast, Ireland.<br /><searchLink fieldCode="AU" term="%22McDyer+JF%22">McDyer JF</searchLink>; Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22McGlothlin+A%22">McGlothlin A</searchLink>; 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Scottish National Blood Transfusion Service, Edinburgh, Scotland.<br /><searchLink fieldCode="AU" term="%22Purcell+DFJ%22">Purcell DFJ</searchLink>; Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Reyes+LF%22">Reyes LF</searchLink>; Universidad de La Sabana, Chia, Colombia.; Clinica Universidad de La Sabana, Chia, Colombia.<br /><searchLink fieldCode="AU" term="%22Richardson+P%22">Richardson P</searchLink>; Welsh Blood Service, Cardiff, Wales.<br /><searchLink fieldCode="AU" term="%22Robitaille+N%22">Robitaille N</searchLink>; Héma-Québec, Montreal, Quebec, Canada.; Division of Hematology and Oncology, Department of Pediatrics, CHU Sainte-Justine, Montreal, Quebec, Canada.; Department of Pediatrics, Université de Montréal, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Rowan+KM%22">Rowan KM</searchLink>; Clinical Trials Unit, Intensive Care National Audit and Research Centre, London, England.<br /><searchLink fieldCode="AU" term="%22Rynne+J%22">Rynne J</searchLink>; School of Immunology and Microbial Sciences, Kings College London, London, England.<br /><searchLink fieldCode="AU" term="%22Saito+H%22">Saito H</searchLink>; Department of Emergency and Critical Care Medicine, St Marianna University School of Medicine, Yokohama City Seibu Hospital, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Santos+M%22">Santos M</searchLink>; Li Ka Shing Knowledge Institute, Unity Health Toronto, St Michael's Hospital, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Saunders+CT%22">Saunders CT</searchLink>; Berry Consultants LLC, Austin, Texas.<br /><searchLink fieldCode="AU" term="%22Serpa+Neto+A%22">Serpa Neto A</searchLink>; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.; Department of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Seymour+CW%22">Seymour CW</searchLink>; Clinical Research Investigation and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.; UPMC Health System Office of Healthcare Innovation, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Silversides+JA%22">Silversides JA</searchLink>; Centre for Experimental Medicine, School of Medicine, Dentistry, and Biomedical Sciences, Queen's University Belfast, Belfast, Ireland.<br /><searchLink fieldCode="AU" term="%22Tinmouth+AA%22">Tinmouth AA</searchLink>; Ottawa Hospital Research Institute, Clinical Epidemiology Unit, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Triulzi+DJ%22">Triulzi DJ</searchLink>; Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Turner+AM%22">Turner AM</searchLink>; Medical Research Institute of New Zealand, Wellington.<br /><searchLink fieldCode="AU" term="%22van+de+Veerdonk+F%22">van de Veerdonk F</searchLink>; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Walsh+TS%22">Walsh TS</searchLink>; University of Edinburgh, Edinburgh, Scotland.<br /><searchLink fieldCode="AU" term="%22Wood+EM%22">Wood EM</searchLink>; Transfusion Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.; Department of Clinical Hematology, Monash Health, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Berry+S%22">Berry S</searchLink>; Berry Consultants LLC, Austin, Texas.<br /><searchLink fieldCode="AU" term="%22Lewis+RJ%22">Lewis RJ</searchLink>; Berry Consultants LLC, Austin, Texas.; Department of Emergency Medicine, Harbor-UCLA Medical Center, Torrance, California.; Department of Emergency Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California.<br /><searchLink fieldCode="AU" term="%22Menon+DK%22">Menon DK</searchLink>; University Division of Anesthesia, Addenbrooke's Hospital Cambridge, Cambridge, England.<br /><searchLink fieldCode="AU" term="%22McArthur+C%22">McArthur C</searchLink>; Clinical Trials Unit, Intensive Care National Audit and Research Centre, London, England.; Department of Critical Care Medicine, Auckland City Hospital, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Zarychanski+R%22">Zarychanski R</searchLink>; Department of Medicine, Critical Care and Hematology/Medical Oncology, University of Manitoba, Winnipeg, Canada.<br /><searchLink fieldCode="AU" term="%22Angus+DC%22">Angus DC</searchLink>; Clinical Research Investigation and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.; UPMC Health System Office of Healthcare Innovation, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Webb+SA%22">Webb SA</searchLink>; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.; St John of God Hospital, Subiaco, Australia.<br /><searchLink fieldCode="AU" term="%22Roberts+DJ%22">Roberts DJ</searchLink>; NHS Blood and Transplant, Oxford, England.; Radcliffe Department of Medicine and BRC Hematology Theme, University of Oxford, Oxford, England.<br /><searchLink fieldCode="AU" term="%22Shankar-Hari+M%22">Shankar-Hari M</searchLink>; School of Immunology and Microbial Sciences, Kings College London, London, England.; Guy's and St Thomas' NHS Foundation Trust, ICU Support Offices, St Thomas' Hospital, London, England.
– Name: AuthorCorporate
  Label: Corporate Authors
  Group: Au
  Data: <searchLink fieldCode="CA" term="%22Writing+Committee+for+the+REMAP-CAP+Investigators%22">Writing Committee for the REMAP-CAP Investigators</searchLink>
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  Data: <searchLink fieldCode="JN" term="%227501160%22">JAMA</searchLink> [JAMA] 2021 Nov 02; Vol. 326 (17), pp. 1690-1702.
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  Data: Journal Article; Multicenter Study; Randomized Controlled Trial; Adaptive Clinical Trial
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  Label: Journal Info
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Medical+Association%22">American Medical Association </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7501160 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1538-3598 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200987484%22">00987484 </searchLink><i>NLM ISO Abbreviation: </i>JAMA <i>Subsets: </i>MEDLINE
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        Value: 10.1001/jama.2021.18178
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        Text: English
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      – TitleFull: Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial.
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              Text: 2021 Nov 02
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