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A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response.

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Title: A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response.
Authors: Luo Y; Center for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. yangluo@broadinstitute.org.; Division of Rheumatology, Immunology, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. yangluo@broadinstitute.org.; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. yangluo@broadinstitute.org.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. yangluo@broadinstitute.org.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. yangluo@broadinstitute.org., Kanai M; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan., Choi W; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea., Li X; Committee on Genetics, Genomics, and Systems Biology, University of Chicago, Chicago, IL, USA., Sakaue S; Center for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Division of Rheumatology, Immunology, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Yamamoto K; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka, Japan., Ogawa K; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan., Gutierrez-Arcelus M; Center for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Division of Rheumatology, Immunology, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Gregersen PK; The Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institute for Medical Research,North Short LIJ Health System, Manhasset, NY, USA., Stuart PE; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA., Elder JT; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.; Ann Arbor Veterans Affairs Hospital, Ann Arbor, MI, USA., Forer L; Institute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University of Innsbruck, Innsbruck, Austria., Schönherr S; Institute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University of Innsbruck, Innsbruck, Austria., Fuchsberger C; Institute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Institute for Biomedicine, Eurac Research, Bolzano, Italy., Smith AV; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Fellay J; Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.; School of Life Sciences, EPFL, Lausanne, Switzerland., Carrington M; Basic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD, USA.; Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA., Haas DW; Vanderbilt University Medical Center, Nashville, TN, USA.; Meharry Medical College, Nashville, TN, USA., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Palmer ND; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Chen YI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Rich SS; Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA., Correa A; Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Wilson JG; Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA., Kathiresan S; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Cardiology Division of the Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Cho MH; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Metspalu A; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Esko T; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Okada Y; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan., Han B; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.; Interdisciplinary Program in Bioengineering, Seoul National University, Seoul, South Korea., McLaren PJ; J.C. Wilt Infectious Diseases Research Centre, National Microbiology Laboratories, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada., Raychaudhuri S; Center for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. soumya@broadinstitute.org.; Division of Rheumatology, Immunology, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. soumya@broadinstitute.org.; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. soumya@broadinstitute.org.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. soumya@broadinstitute.org.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. soumya@broadinstitute.org.; Centre for Genetics and Genomics Versus Arthritis, University of Manchester, Manchester, UK. soumya@broadinstitute.org.
Corporate Authors: NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
Source: Nature genetics [Nat Genet] 2021 Oct; Vol. 53 (10), pp. 1504-1516. Date of Electronic Publication: 2021 Oct 05.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
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