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Therapeutic targeting of SLC6A8 creatine transporter suppresses colon cancer progression and modulates human creatine levels.

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Title: Therapeutic targeting of SLC6A8 creatine transporter suppresses colon cancer progression and modulates human creatine levels.
Authors: Kurth I; Inspirna, Inc., 310 E. 67th St, New York, NY 10065, USA., Yamaguchi N; Laboratory of Systems Cancer Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA., Andreu-Agullo C; Inspirna, Inc., 310 E. 67th St, New York, NY 10065, USA., Tian HS; Laboratory of Systems Cancer Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA., Sridhar S; Inspirna, Inc., 310 E. 67th St, New York, NY 10065, USA., Takeda S; Inspirna, Inc., 310 E. 67th St, New York, NY 10065, USA., Gonsalves FC; Inspirna, Inc., 310 E. 67th St, New York, NY 10065, USA., Loo JM; Laboratory of Systems Cancer Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.; Laboratory of Precision Oncology and Tumor Evolution, Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672, Singapore., Barlas A; Memorial Sloan Kettering Cancer Center, 275 York Ave., New York, NY 10065, USA., Manova-Todorova K; Memorial Sloan Kettering Cancer Center, 275 York Ave., New York, NY 10065, USA., Busby R; Inspirna, Inc., 310 E. 67th St, New York, NY 10065, USA., Bendell JC; Sarah Cannon Research Institute, 250 25th Ave N, Nashville, TN 37203, USA., Strauss J; Mary Crowley Cancer Research, Building C, 7777 Forest Ln #707, Dallas, TX 75230, USA., Fakih M; City of Hope Comprehensive Cancer Center, 1500 E Duarte Rd, Duarte, CA 91010, USA., McRee AJ; The University of North Carolina at Chapel Hill, 27599 Chapel Hill, NC, USA., Hendifar AE; Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA., Rosen LS; Jonsson Comprehensive Cancer Center, University of California, 10833 Le Conte Ave, Los Angeles, CA 90024, USA., Cercek A; Memorial Sloan Kettering Cancer Center, 275 York Ave., New York, NY 10065, USA., Wasserman R; Inspirna, Inc., 310 E. 67th St, New York, NY 10065, USA., Szarek M; Inspirna, Inc., 310 E. 67th St, New York, NY 10065, USA.; University of Colorado School of Medicine, 13001 E 17th Pl, Aurora, CO 80045, USA.; SUNY Downstate Health Sciences University School of Public Health, 450 Clarkson Ave, Brooklyn, NY 11203, USA., Spector SL; Inspirna, Inc., 310 E. 67th St, New York, NY 10065, USA., Raza S; Inspirna, Inc., 310 E. 67th St, New York, NY 10065, USA., Tavazoie MF; Inspirna, Inc., 310 E. 67th St, New York, NY 10065, USA., Tavazoie SF; Laboratory of Systems Cancer Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
Source: Science advances [Sci Adv] 2021 Oct 08; Vol. 7 (41), pp. eabi7511. Date of Electronic Publication: 2021 Oct 06.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: Therapeutic targeting of SLC6A8 creatine transporter suppresses colon cancer progression and modulates human creatine levels.
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  Data: <searchLink fieldCode="AU" term="%22Kurth+I%22">Kurth I</searchLink>; Inspirna, Inc., 310 E. 67th St, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Yamaguchi+N%22">Yamaguchi N</searchLink>; Laboratory of Systems Cancer Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Andreu-Agullo+C%22">Andreu-Agullo C</searchLink>; Inspirna, Inc., 310 E. 67th St, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Tian+HS%22">Tian HS</searchLink>; Laboratory of Systems Cancer Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Sridhar+S%22">Sridhar S</searchLink>; Inspirna, Inc., 310 E. 67th St, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Takeda+S%22">Takeda S</searchLink>; Inspirna, Inc., 310 E. 67th St, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Gonsalves+FC%22">Gonsalves FC</searchLink>; Inspirna, Inc., 310 E. 67th St, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Loo+JM%22">Loo JM</searchLink>; Laboratory of Systems Cancer Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.; Laboratory of Precision Oncology and Tumor Evolution, Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672, Singapore.<br /><searchLink fieldCode="AU" term="%22Barlas+A%22">Barlas A</searchLink>; Memorial Sloan Kettering Cancer Center, 275 York Ave., New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Manova-Todorova+K%22">Manova-Todorova K</searchLink>; Memorial Sloan Kettering Cancer Center, 275 York Ave., New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Busby+R%22">Busby R</searchLink>; Inspirna, Inc., 310 E. 67th St, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Bendell+JC%22">Bendell JC</searchLink>; Sarah Cannon Research Institute, 250 25th Ave N, Nashville, TN 37203, USA.<br /><searchLink fieldCode="AU" term="%22Strauss+J%22">Strauss J</searchLink>; Mary Crowley Cancer Research, Building C, 7777 Forest Ln #707, Dallas, TX 75230, USA.<br /><searchLink fieldCode="AU" term="%22Fakih+M%22">Fakih M</searchLink>; City of Hope Comprehensive Cancer Center, 1500 E Duarte Rd, Duarte, CA 91010, USA.<br /><searchLink fieldCode="AU" term="%22McRee+AJ%22">McRee AJ</searchLink>; The University of North Carolina at Chapel Hill, 27599 Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Hendifar+AE%22">Hendifar AE</searchLink>; Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA.<br /><searchLink fieldCode="AU" term="%22Rosen+LS%22">Rosen LS</searchLink>; Jonsson Comprehensive Cancer Center, University of California, 10833 Le Conte Ave, Los Angeles, CA 90024, USA.<br /><searchLink fieldCode="AU" term="%22Cercek+A%22">Cercek A</searchLink>; Memorial Sloan Kettering Cancer Center, 275 York Ave., New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Wasserman+R%22">Wasserman R</searchLink>; Inspirna, Inc., 310 E. 67th St, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Szarek+M%22">Szarek M</searchLink>; Inspirna, Inc., 310 E. 67th St, New York, NY 10065, USA.; University of Colorado School of Medicine, 13001 E 17th Pl, Aurora, CO 80045, USA.; SUNY Downstate Health Sciences University School of Public Health, 450 Clarkson Ave, Brooklyn, NY 11203, USA.<br /><searchLink fieldCode="AU" term="%22Spector+SL%22">Spector SL</searchLink>; Inspirna, Inc., 310 E. 67th St, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Raza+S%22">Raza S</searchLink>; Inspirna, Inc., 310 E. 67th St, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Tavazoie+MF%22">Tavazoie MF</searchLink>; Inspirna, Inc., 310 E. 67th St, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Tavazoie+SF%22">Tavazoie SF</searchLink>; Laboratory of Systems Cancer Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
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