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Polo-like kinase 2 inhibition reduces serine-129 phosphorylation of physiological nuclear alpha-synuclein but not of the aggregated alpha-synuclein.

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Title: Polo-like kinase 2 inhibition reduces serine-129 phosphorylation of physiological nuclear alpha-synuclein but not of the aggregated alpha-synuclein.
Authors: Elfarrash S; Danish Research Institute of Translational Neuroscience-DANDRITE, Aarhus University, Aarhus, Denmark.; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Department of Physiology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.; MERC-Medical Experimental Research Center, Faculty of Medicine, Mansoura University, Mansoura, Egypt., Jensen NM; Danish Research Institute of Translational Neuroscience-DANDRITE, Aarhus University, Aarhus, Denmark.; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Ferreira N; Danish Research Institute of Translational Neuroscience-DANDRITE, Aarhus University, Aarhus, Denmark.; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Schmidt SI; Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark., Gregersen E; Danish Research Institute of Translational Neuroscience-DANDRITE, Aarhus University, Aarhus, Denmark.; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Vestergaard MV; Danish Research Institute of Translational Neuroscience-DANDRITE, Aarhus University, Aarhus, Denmark.; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Nabavi S; Danish Research Institute of Translational Neuroscience-DANDRITE, Aarhus University, Aarhus, Denmark.; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark., Meyer M; Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.; Department of Neurology, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, BRIDGE-Brain Research Inter-Disciplinary Guided Excellence, University of Southern Denmark, Odense, Denmark., Jensen PH; Danish Research Institute of Translational Neuroscience-DANDRITE, Aarhus University, Aarhus, Denmark.; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Source: PloS one [PLoS One] 2021 Oct 06; Vol. 16 (10), pp. e0252635. Date of Electronic Publication: 2021 Oct 06 (Print Publication: 2021).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Polo-like kinase 2 inhibition reduces serine-129 phosphorylation of physiological nuclear alpha-synuclein but not of the aggregated alpha-synuclein.
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  Data: <searchLink fieldCode="AU" term="%22Elfarrash+S%22">Elfarrash S</searchLink>; Danish Research Institute of Translational Neuroscience-DANDRITE, Aarhus University, Aarhus, Denmark.; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Department of Physiology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.; MERC-Medical Experimental Research Center, Faculty of Medicine, Mansoura University, Mansoura, Egypt.<br /><searchLink fieldCode="AU" term="%22Jensen+NM%22">Jensen NM</searchLink>; Danish Research Institute of Translational Neuroscience-DANDRITE, Aarhus University, Aarhus, Denmark.; Department of Biomedicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Ferreira+N%22">Ferreira N</searchLink>; Danish Research Institute of Translational Neuroscience-DANDRITE, Aarhus University, Aarhus, Denmark.; Department of Biomedicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Schmidt+SI%22">Schmidt SI</searchLink>; Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Gregersen+E%22">Gregersen E</searchLink>; Danish Research Institute of Translational Neuroscience-DANDRITE, Aarhus University, Aarhus, Denmark.; Department of Biomedicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Vestergaard+MV%22">Vestergaard MV</searchLink>; Danish Research Institute of Translational Neuroscience-DANDRITE, Aarhus University, Aarhus, Denmark.; Department of Biomedicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Nabavi+S%22">Nabavi S</searchLink>; Danish Research Institute of Translational Neuroscience-DANDRITE, Aarhus University, Aarhus, Denmark.; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Meyer+M%22">Meyer M</searchLink>; Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.; Department of Neurology, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, BRIDGE-Brain Research Inter-Disciplinary Guided Excellence, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Jensen+PH%22">Jensen PH</searchLink>; Danish Research Institute of Translational Neuroscience-DANDRITE, Aarhus University, Aarhus, Denmark.; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
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  Data: <searchLink fieldCode="JN" term="%22101285081%22">PloS one</searchLink> [PLoS One] 2021 Oct 06; Vol. 16 (10), pp. e0252635. <i>Date of Electronic Publication: </i>2021 Oct 06 (<i>Print Publication: </i>2021).
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