Efficacy and Safety of Therapeutic-Dose Heparin vs Standard Prophylactic or Intermediate-Dose Heparins for Thromboprophylaxis in High-risk Hospitalized Patients With COVID-19: The HEP-COVID Randomized Clinical Trial.
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| Title: | Efficacy and Safety of Therapeutic-Dose Heparin vs Standard Prophylactic or Intermediate-Dose Heparins for Thromboprophylaxis in High-risk Hospitalized Patients With COVID-19: The HEP-COVID Randomized Clinical Trial. |
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| Authors: | Spyropoulos AC; Institute of Health System Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.; Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.; Department of Obstetrics and Gynecology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia., Goldin M; Institute of Health System Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.; Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York., Giannis D; Institute of Health System Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York., Diab W; Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York., Wang J; Institute of Health System Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.; Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York., Khanijo S; Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York., Mignatti A; Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.; Department of Cardiology, Lenox Hill Hospital, Northwell Health, New York, New York., Gianos E; Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.; Department of Cardiology, Lenox Hill Hospital, Northwell Health, New York, New York., Cohen M; Department of Medicine, Newark Beth Israel Medical Center, Newark, New Jersey., Sharifova G; Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York., Lund JM; WellSpan York Hospital, York, Pennsylvania., Tafur A; Department of Medicine, Cardiovascular Institute, NorthShore University HealthSystem, Evanston, Illinois.; Division of Cardiology, Pritzker School of Medicine, University of Chicago, Chicago, Illinois., Lewis PA; BayCare Health System, Inc, Clearwater, Florida., Cohoon KP; Division of Cardiovascular Medicine, Department of Medicine, Froedtert & the Medical College of Wisconsin, Milwaukee., Rahman H; Institute of Health System Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.; Biostatistics Unit, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York., Sison CP; Institute of Health System Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.; Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.; Biostatistics Unit, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York., Lesser ML; Institute of Health System Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.; Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.; Biostatistics Unit, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York., Ochani K; Institute of Health System Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York., Agrawal N; Institute of Health System Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York., Hsia J; Colorado Prevention Center (CPC) Clinical Research, Aurora.; Division of Cardiology, University of Colorado School of Medicine, University of Colorado, Aurora., Anderson VE; Colorado Prevention Center (CPC) Clinical Research, Aurora., Bonaca M; Colorado Prevention Center (CPC) Clinical Research, Aurora.; Division of Cardiology, University of Colorado School of Medicine, University of Colorado, Aurora., Halperin JL; Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai Medical Center, New York, New York., Weitz JI; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.; Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada. |
| Corporate Authors: | HEP-COVID Investigators |
| Source: | JAMA internal medicine [JAMA Intern Med] 2021 Dec 01; Vol. 181 (12), pp. 1612-1620. |
| Publication Type: | Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: American Medical Association Country of Publication: United States NLM ID: 101589534 Publication Model: Print Cited Medium: Internet ISSN: 2168-6114 (Electronic) Linking ISSN: 21686106 NLM ISO Abbreviation: JAMA Intern Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 34617959 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Efficacy and Safety of Therapeutic-Dose Heparin vs Standard Prophylactic or Intermediate-Dose Heparins for Thromboprophylaxis in High-risk Hospitalized Patients With COVID-19: The HEP-COVID Randomized Clinical Trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Spyropoulos+AC%22">Spyropoulos AC</searchLink>; Institute of Health System Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.; Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.; Department of Obstetrics and Gynecology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Goldin+M%22">Goldin M</searchLink>; Institute of Health System Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.; Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.<br /><searchLink fieldCode="AU" term="%22Giannis+D%22">Giannis D</searchLink>; Institute of Health System Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.<br /><searchLink fieldCode="AU" term="%22Diab+W%22">Diab W</searchLink>; Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Institute of Health System Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.; Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.<br /><searchLink fieldCode="AU" term="%22Khanijo+S%22">Khanijo S</searchLink>; Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.<br /><searchLink fieldCode="AU" term="%22Mignatti+A%22">Mignatti A</searchLink>; Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.; Department of Cardiology, Lenox Hill Hospital, Northwell Health, New York, New York.<br /><searchLink fieldCode="AU" term="%22Gianos+E%22">Gianos E</searchLink>; Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.; Department of Cardiology, Lenox Hill Hospital, Northwell Health, New York, New York.<br /><searchLink fieldCode="AU" term="%22Cohen+M%22">Cohen M</searchLink>; Department of Medicine, Newark Beth Israel Medical Center, Newark, New Jersey.<br /><searchLink fieldCode="AU" term="%22Sharifova+G%22">Sharifova G</searchLink>; Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.<br /><searchLink fieldCode="AU" term="%22Lund+JM%22">Lund JM</searchLink>; WellSpan York Hospital, York, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Tafur+A%22">Tafur A</searchLink>; Department of Medicine, Cardiovascular Institute, NorthShore University HealthSystem, Evanston, Illinois.; Division of Cardiology, Pritzker School of Medicine, University of Chicago, Chicago, Illinois.<br /><searchLink fieldCode="AU" term="%22Lewis+PA%22">Lewis PA</searchLink>; BayCare Health System, Inc, Clearwater, Florida.<br /><searchLink fieldCode="AU" term="%22Cohoon+KP%22">Cohoon KP</searchLink>; Division of Cardiovascular Medicine, Department of Medicine, Froedtert & the Medical College of Wisconsin, Milwaukee.<br /><searchLink fieldCode="AU" term="%22Rahman+H%22">Rahman H</searchLink>; Institute of Health System Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.; Biostatistics Unit, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.<br /><searchLink fieldCode="AU" term="%22Sison+CP%22">Sison CP</searchLink>; Institute of Health System Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.; Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.; Biostatistics Unit, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.<br /><searchLink fieldCode="AU" term="%22Lesser+ML%22">Lesser ML</searchLink>; Institute of Health System Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.; Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.; Biostatistics Unit, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.<br /><searchLink fieldCode="AU" term="%22Ochani+K%22">Ochani K</searchLink>; Institute of Health System Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.<br /><searchLink fieldCode="AU" term="%22Agrawal+N%22">Agrawal N</searchLink>; Institute of Health System Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.<br /><searchLink fieldCode="AU" term="%22Hsia+J%22">Hsia J</searchLink>; Colorado Prevention Center (CPC) Clinical Research, Aurora.; Division of Cardiology, University of Colorado School of Medicine, University of Colorado, Aurora.<br /><searchLink fieldCode="AU" term="%22Anderson+VE%22">Anderson VE</searchLink>; Colorado Prevention Center (CPC) Clinical Research, Aurora.<br /><searchLink fieldCode="AU" term="%22Bonaca+M%22">Bonaca M</searchLink>; Colorado Prevention Center (CPC) Clinical Research, Aurora.; Division of Cardiology, University of Colorado School of Medicine, University of Colorado, Aurora.<br /><searchLink fieldCode="AU" term="%22Halperin+JL%22">Halperin JL</searchLink>; Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai Medical Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Weitz+JI%22">Weitz JI</searchLink>; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.; Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada. – Name: AuthorCorporate Label: Corporate Authors Group: Au Data: <searchLink fieldCode="CA" term="%22HEP-COVID+Investigators%22">HEP-COVID Investigators</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101589534%22">JAMA internal medicine</searchLink> [JAMA Intern Med] 2021 Dec 01; Vol. 181 (12), pp. 1612-1620. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Medical+Association%22">American Medical Association </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101589534 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>2168-6114 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2221686106%22">21686106 </searchLink><i>NLM ISO Abbreviation: </i>JAMA Intern Med <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=34617959 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1001/jamainternmed.2021.6203 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 1612 Titles: – TitleFull: Efficacy and Safety of Therapeutic-Dose Heparin vs Standard Prophylactic or Intermediate-Dose Heparins for Thromboprophylaxis in High-risk Hospitalized Patients With COVID-19: The HEP-COVID Randomized Clinical Trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Spyropoulos AC – PersonEntity: Name: NameFull: Goldin M – PersonEntity: Name: NameFull: Giannis D – PersonEntity: Name: NameFull: Diab W – PersonEntity: Name: NameFull: Wang J – PersonEntity: Name: NameFull: Khanijo S – PersonEntity: Name: NameFull: Mignatti A – PersonEntity: Name: NameFull: Gianos E – PersonEntity: Name: NameFull: Cohen M – PersonEntity: Name: NameFull: Sharifova G – PersonEntity: Name: NameFull: Lund JM – PersonEntity: Name: NameFull: Tafur A – PersonEntity: Name: NameFull: Lewis PA – PersonEntity: Name: NameFull: Cohoon KP – PersonEntity: Name: NameFull: Rahman H – PersonEntity: Name: NameFull: Sison CP – PersonEntity: Name: NameFull: Lesser ML – PersonEntity: Name: NameFull: Ochani K – PersonEntity: Name: NameFull: Agrawal N – PersonEntity: Name: NameFull: Hsia J – PersonEntity: Name: NameFull: Anderson VE – PersonEntity: Name: NameFull: Bonaca M – PersonEntity: Name: NameFull: Halperin JL – PersonEntity: Name: NameFull: Weitz JI IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: 2021 Dec 01 Type: published Y: 2021 Identifiers: – Type: issn-electronic Value: 2168-6114 Numbering: – Type: volume Value: 181 – Type: issue Value: 12 Titles: – TitleFull: JAMA internal medicine Type: main |
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