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The microglial NLRP3 inflammasome is involved in human SARS-CoV-2 cerebral pathogenicity: A report of three post-mortem cases.

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Title: The microglial NLRP3 inflammasome is involved in human SARS-CoV-2 cerebral pathogenicity: A report of three post-mortem cases.
Authors: Cama VF; Center for Genetic Engineering and Biotechnology (CIGB), Ave. 31 e/158 y 190, Cubanacán, Playa, PO Box 6162, Havana, Cuba; Latin American School of Medicine, Carretera Panamericana Km 3 1/2, Playa, Havana, 11600, Cuba.. Electronic address: viviana.falcon@cigb.edu.cu., Marín-Prida J; Center for Research and Biological Evaluations, Institute of Pharmacy and Food, University of Havana, Ave. 23 e/214 y 222, La Lisa, PO Box: 430, Havana, Cuba. Electronic address: javier.marin@ifal.uh.cu., Acosta-Rivero N; Center of Protein Research, Department of Biochemistry, Faculty of Biology, University of Havana, Havana, Cuba. Electronic address: nelson.acosta@fbio.uh.cu., Acosta EF; Center for Advanced Studies of Cuba, Havana, Cuba; Latin American School of Medicine, Carretera Panamericana Km 3 1/2, Playa, Havana, 11600, Cuba.. Electronic address: emilio.am@cea.cu., Díaz LO; Center for Genetic Engineering and Biotechnology (CIGB), Ave. 31 e/158 y 190, Cubanacán, Playa, PO Box 6162, Havana, Cuba. Electronic address: leonardo.oramas@cigb.edu.cu., Casadesús AV; Direction of Immunology and Immunotherapy, Center of Molecular Immunology, Havana, Cuba. Electronic address: anav@cim.sld.cu., Fernández-Marrero B; Direction of Immunology and Immunotherapy, Center of Molecular Immunology, Havana, Cuba. Electronic address: briandyf@cim.sld.cu., Gilva-Rodríguez N; Center for Genetic Engineering and Biotechnology (CIGB), Ave. 31 e/158 y 190, Cubanacán, Playa, PO Box 6162, Havana, Cuba. Electronic address: nathalie.gilva@cigb.edu.cu., Cremata-García D; Center for Genetic Engineering and Biotechnology (CIGB), Ave. 31 e/158 y 190, Cubanacán, Playa, PO Box 6162, Havana, Cuba. Electronic address: daina.cremata@cigb.edu.cu., Cervantes-Llanos M; Center for Genetic Engineering and Biotechnology (CIGB), Ave. 31 e/158 y 190, Cubanacán, Playa, PO Box 6162, Havana, Cuba. Electronic address: majel.cervantes@cigb.edu.cu., Piniella-Matamoros B; Center for Genetic Engineering and Biotechnology (CIGB), Ave. 31 e/158 y 190, Cubanacán, Playa, PO Box 6162, Havana, Cuba. Electronic address: beatriz.piniella@cigb.edu.cu., Sánchez D; Center for Advanced Studies of Cuba, Havana, Cuba. Electronic address: daisy.sg@cea.cu., Del Rosario-Cruz L; Hospital Militar Central 'Dr. Luis Díaz Soto', Avenida Monumental km 2, Habana delEste, Havana, Cuba. Electronic address: lrosarioc@infomed.sld.cu., Borrajero I; Hospital Clínico Quirúrgico 'Hermanos Ameijeiras', Havana, Cuba. Electronic address: telepatol@hha.sld.cu., Díaz A; Center for Advanced Studies of Cuba, Havana, Cuba. Electronic address: angelina.dg@cea.cu., González Y; Center for Advanced Studies of Cuba, Havana, Cuba. Electronic address: yorexis.ga@cea.cu., Pentón-Arias E; Center for Genetic Engineering and Biotechnology (CIGB), Ave. 31 e/158 y 190, Cubanacán, Playa, PO Box 6162, Havana, Cuba; Latin American School of Medicine, Carretera Panamericana Km 3 1/2, Playa, Havana, 11600, Cuba.. Electronic address: eduardo.penton@cigb.edu.cu., Montero-González T; Hospital Militar Central 'Dr. Luis Díaz Soto', Avenida Monumental km 2, Habana delEste, Havana, Cuba. Electronic address: teremg@infomed.sld.cu., Guillen-Nieto G; Center for Genetic Engineering and Biotechnology (CIGB), Ave. 31 e/158 y 190, Cubanacán, Playa, PO Box 6162, Havana, Cuba; Latin American School of Medicine, Carretera Panamericana Km 3 1/2, Playa, Havana, 11600, Cuba.. Electronic address: gerardo.guillen@cigb.edu.cu., Pentón-Rol G; Center for Genetic Engineering and Biotechnology (CIGB), Ave. 31 e/158 y 190, Cubanacán, Playa, PO Box 6162, Havana, Cuba; Latin American School of Medicine, Carretera Panamericana Km 3 1/2, Playa, Havana, 11600, Cuba.. Electronic address: giselle.penton@cigb.edu.cu.
Source: Journal of neuroimmunology [J Neuroimmunol] 2021 Dec 15; Vol. 361, pp. 577728. Date of Electronic Publication: 2021 Sep 29.
Publication Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 8109498 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8421 (Electronic) Linking ISSN: 01655728 NLM ISO Abbreviation: J Neuroimmunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: The microglial NLRP3 inflammasome is involved in human SARS-CoV-2 cerebral pathogenicity: A report of three post-mortem cases.
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  Data: <searchLink fieldCode="AU" term="%22Cama+VF%22">Cama VF</searchLink>; Center for Genetic Engineering and Biotechnology (CIGB), Ave. 31 e/158 y 190, Cubanacán, Playa, PO Box 6162, Havana, Cuba; Latin American School of Medicine, Carretera Panamericana Km 3 1/2, Playa, Havana, 11600, Cuba.. Electronic address: viviana.falcon@cigb.edu.cu.<br /><searchLink fieldCode="AU" term="%22Marín-Prida+J%22">Marín-Prida J</searchLink>; Center for Research and Biological Evaluations, Institute of Pharmacy and Food, University of Havana, Ave. 23 e/214 y 222, La Lisa, PO Box: 430, Havana, Cuba. Electronic address: javier.marin@ifal.uh.cu.<br /><searchLink fieldCode="AU" term="%22Acosta-Rivero+N%22">Acosta-Rivero N</searchLink>; Center of Protein Research, Department of Biochemistry, Faculty of Biology, University of Havana, Havana, Cuba. Electronic address: nelson.acosta@fbio.uh.cu.<br /><searchLink fieldCode="AU" term="%22Acosta+EF%22">Acosta EF</searchLink>; Center for Advanced Studies of Cuba, Havana, Cuba; Latin American School of Medicine, Carretera Panamericana Km 3 1/2, Playa, Havana, 11600, Cuba.. Electronic address: emilio.am@cea.cu.<br /><searchLink fieldCode="AU" term="%22Díaz+LO%22">Díaz LO</searchLink>; Center for Genetic Engineering and Biotechnology (CIGB), Ave. 31 e/158 y 190, Cubanacán, Playa, PO Box 6162, Havana, Cuba. Electronic address: leonardo.oramas@cigb.edu.cu.<br /><searchLink fieldCode="AU" term="%22Casadesús+AV%22">Casadesús AV</searchLink>; Direction of Immunology and Immunotherapy, Center of Molecular Immunology, Havana, Cuba. Electronic address: anav@cim.sld.cu.<br /><searchLink fieldCode="AU" term="%22Fernández-Marrero+B%22">Fernández-Marrero B</searchLink>; Direction of Immunology and Immunotherapy, Center of Molecular Immunology, Havana, Cuba. Electronic address: briandyf@cim.sld.cu.<br /><searchLink fieldCode="AU" term="%22Gilva-Rodríguez+N%22">Gilva-Rodríguez N</searchLink>; Center for Genetic Engineering and Biotechnology (CIGB), Ave. 31 e/158 y 190, Cubanacán, Playa, PO Box 6162, Havana, Cuba. Electronic address: nathalie.gilva@cigb.edu.cu.<br /><searchLink fieldCode="AU" term="%22Cremata-García+D%22">Cremata-García D</searchLink>; Center for Genetic Engineering and Biotechnology (CIGB), Ave. 31 e/158 y 190, Cubanacán, Playa, PO Box 6162, Havana, Cuba. Electronic address: daina.cremata@cigb.edu.cu.<br /><searchLink fieldCode="AU" term="%22Cervantes-Llanos+M%22">Cervantes-Llanos M</searchLink>; Center for Genetic Engineering and Biotechnology (CIGB), Ave. 31 e/158 y 190, Cubanacán, Playa, PO Box 6162, Havana, Cuba. Electronic address: majel.cervantes@cigb.edu.cu.<br /><searchLink fieldCode="AU" term="%22Piniella-Matamoros+B%22">Piniella-Matamoros B</searchLink>; Center for Genetic Engineering and Biotechnology (CIGB), Ave. 31 e/158 y 190, Cubanacán, Playa, PO Box 6162, Havana, Cuba. Electronic address: beatriz.piniella@cigb.edu.cu.<br /><searchLink fieldCode="AU" term="%22Sánchez+D%22">Sánchez D</searchLink>; Center for Advanced Studies of Cuba, Havana, Cuba. Electronic address: daisy.sg@cea.cu.<br /><searchLink fieldCode="AU" term="%22Del+Rosario-Cruz+L%22">Del Rosario-Cruz L</searchLink>; Hospital Militar Central 'Dr. Luis Díaz Soto', Avenida Monumental km 2, Habana delEste, Havana, Cuba. Electronic address: lrosarioc@infomed.sld.cu.<br /><searchLink fieldCode="AU" term="%22Borrajero+I%22">Borrajero I</searchLink>; Hospital Clínico Quirúrgico 'Hermanos Ameijeiras', Havana, Cuba. Electronic address: telepatol@hha.sld.cu.<br /><searchLink fieldCode="AU" term="%22Díaz+A%22">Díaz A</searchLink>; Center for Advanced Studies of Cuba, Havana, Cuba. Electronic address: angelina.dg@cea.cu.<br /><searchLink fieldCode="AU" term="%22González+Y%22">González Y</searchLink>; Center for Advanced Studies of Cuba, Havana, Cuba. Electronic address: yorexis.ga@cea.cu.<br /><searchLink fieldCode="AU" term="%22Pentón-Arias+E%22">Pentón-Arias E</searchLink>; Center for Genetic Engineering and Biotechnology (CIGB), Ave. 31 e/158 y 190, Cubanacán, Playa, PO Box 6162, Havana, Cuba; Latin American School of Medicine, Carretera Panamericana Km 3 1/2, Playa, Havana, 11600, Cuba.. Electronic address: eduardo.penton@cigb.edu.cu.<br /><searchLink fieldCode="AU" term="%22Montero-González+T%22">Montero-González T</searchLink>; Hospital Militar Central 'Dr. Luis Díaz Soto', Avenida Monumental km 2, Habana delEste, Havana, Cuba. Electronic address: teremg@infomed.sld.cu.<br /><searchLink fieldCode="AU" term="%22Guillen-Nieto+G%22">Guillen-Nieto G</searchLink>; Center for Genetic Engineering and Biotechnology (CIGB), Ave. 31 e/158 y 190, Cubanacán, Playa, PO Box 6162, Havana, Cuba; Latin American School of Medicine, Carretera Panamericana Km 3 1/2, Playa, Havana, 11600, Cuba.. Electronic address: gerardo.guillen@cigb.edu.cu.<br /><searchLink fieldCode="AU" term="%22Pentón-Rol+G%22">Pentón-Rol G</searchLink>; Center for Genetic Engineering and Biotechnology (CIGB), Ave. 31 e/158 y 190, Cubanacán, Playa, PO Box 6162, Havana, Cuba; Latin American School of Medicine, Carretera Panamericana Km 3 1/2, Playa, Havana, 11600, Cuba.. Electronic address: giselle.penton@cigb.edu.cu.
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  Data: <searchLink fieldCode="JN" term="%228109498%22">Journal of neuroimmunology</searchLink> [J Neuroimmunol] 2021 Dec 15; Vol. 361, pp. 577728. <i>Date of Electronic Publication: </i>2021 Sep 29.
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