Replacing the SpCas9 HNH domain by deaminases generates compact base editors with an alternative targeting scope.
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| Title: | Replacing the SpCas9 HNH domain by deaminases generates compact base editors with an alternative targeting scope. |
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| Authors: | Villiger L; Department of Biology, ETH Zurich, Institute for Molecular Health Sciences, Zurich, Switzerland.; University of Zurich, Institute of Pharmacology and Toxicology, Zurich, Switzerland., Schmidheini L; Department of Biology, ETH Zurich, Institute for Molecular Health Sciences, Zurich, Switzerland.; University of Zurich, Institute of Pharmacology and Toxicology, Zurich, Switzerland., Mathis N; University of Zurich, Institute of Pharmacology and Toxicology, Zurich, Switzerland., Rothgangl T; University of Zurich, Institute of Pharmacology and Toxicology, Zurich, Switzerland., Marquart K; Department of Biology, ETH Zurich, Institute for Molecular Health Sciences, Zurich, Switzerland.; University of Zurich, Institute of Pharmacology and Toxicology, Zurich, Switzerland., Schwank G; Department of Biology, ETH Zurich, Institute for Molecular Health Sciences, Zurich, Switzerland.; University of Zurich, Institute of Pharmacology and Toxicology, Zurich, Switzerland. |
| Source: | Molecular therapy. Nucleic acids [Mol Ther Nucleic Acids] 2021 Aug 26; Vol. 26, pp. 502-510. Date of Electronic Publication: 2021 Aug 26 (Print Publication: 2021). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Cell Press Country of Publication: United States NLM ID: 101581621 Publication Model: eCollection Cited Medium: Print ISSN: 2162-2531 (Print) Linking ISSN: 21622531 NLM ISO Abbreviation: Mol Ther Nucleic Acids Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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