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Selective Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibition by the SCH772984 Compound Attenuates In Vitro and In Vivo Inflammatory Responses and Prolongs Survival in Murine Sepsis Models.

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Title: Selective Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibition by the SCH772984 Compound Attenuates In Vitro and In Vivo Inflammatory Responses and Prolongs Survival in Murine Sepsis Models.
Authors: Kopczynski M; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland., Rumienczyk I; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland., Kulecka M; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland.; Department of Gastroenterology, Hepatology and Clinical Oncology, Centre for Postgraduate Medical Education, 01-813 Warsaw, Poland., Statkiewicz M; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland., Pysniak K; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland., Sandowska-Markiewicz Z; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland., Wojcik-Trechcinska U; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland., Goryca K; Genomics Core Facility, Centre of New Technologies, University of Warsaw, 02-097 Warsaw, Poland., Pyziak K; Biology R&D, Ryvu Therapeutics S.A., 30-394 Krakow, Poland., Majewska E; Biology R&D, Ryvu Therapeutics S.A., 30-394 Krakow, Poland., Masiejczyk M; Biology R&D, Ryvu Therapeutics S.A., 30-394 Krakow, Poland., Wojcik-Jaszczynska K; Biology R&D, Ryvu Therapeutics S.A., 30-394 Krakow, Poland., Rzymski T; Biology R&D, Ryvu Therapeutics S.A., 30-394 Krakow, Poland., Bomsztyk K; UW Medicine South Lake Union, University of Washington, Seattle, WA 98109, USA., Ostrowski J; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland.; Department of Gastroenterology, Hepatology and Clinical Oncology, Centre for Postgraduate Medical Education, 01-813 Warsaw, Poland., Mikula M; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland.
Source: International journal of molecular sciences [Int J Mol Sci] 2021 Sep 22; Vol. 22 (19). Date of Electronic Publication: 2021 Sep 22.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Selective Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibition by the SCH772984 Compound Attenuates In Vitro and In Vivo Inflammatory Responses and Prolongs Survival in Murine Sepsis Models.
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