Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin chains.

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Title: Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin chains.
Authors: Song B; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Chen Y; Laboratory of Molecular Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA., Liu X; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Yuan F; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Tan EYJ; NTU Institute of Structural Biology, Nanyang Technological University, EMB 06-01, 59 Nanyang Drive, Singapore 636921, Singapore; School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 636921, Singapore., Lei Y; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Song N; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Han Y; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Pascal BD; Omics Informatics LLC, Honolulu, HI 96813, USA., Griffin PR; The Scripps Research Institute, Department of Molecular Medicine, Jupiter, FL 33458, USA., Luo C; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 310024, China; The Center for Chemical Biology, Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Wu B; NTU Institute of Structural Biology, Nanyang Technological University, EMB 06-01, 59 Nanyang Drive, Singapore 636921, Singapore; School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 636921, Singapore., Luo D; Lee Kong Chian School of Medicine, Nanyang Technological University, EMB 03-07, 59 Nanyang Drive, Singapore 636921, Singapore; NTU Institute of Structural Biology, Nanyang Technological University, EMB 06-01, 59 Nanyang Drive, Singapore 636921, Singapore; School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 636921, Singapore., Zheng J; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 310024, China. Electronic address: jzheng@simm.ac.cn.
Source: Immunity [Immunity] 2021 Oct 12; Vol. 54 (10), pp. 2218-2230.e5.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9432918 Publication Model: Print Cited Medium: Internet ISSN: 1097-4180 (Electronic) Linking ISSN: 10747613 NLM ISO Abbreviation: Immunity Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1097-4180
DOI:10.1016/j.immuni.2021.09.008