Tumor DNA-methylome derived epigenetic fingerprint identifies HPV-negative head and neck patients at risk for locoregional recurrence after postoperative radiochemotherapy.
Saved in:
| Title: | Tumor DNA-methylome derived epigenetic fingerprint identifies HPV-negative head and neck patients at risk for locoregional recurrence after postoperative radiochemotherapy. |
|---|---|
| Authors: | Tawk B; German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital (UKHD), Heidelberg, Germany.; Division of Molecular and Translational Radiation Oncology, Department of Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany.; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University, Heidelberg, Germany., Wirkner U; German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital (UKHD), Heidelberg, Germany.; Division of Molecular and Translational Radiation Oncology, Department of Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany.; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University, Heidelberg, Germany., Schwager C; German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital (UKHD), Heidelberg, Germany.; Division of Molecular and Translational Radiation Oncology, Department of Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany.; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University, Heidelberg, Germany., Rein K; German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital (UKHD), Heidelberg, Germany.; Division of Molecular and Translational Radiation Oncology, Department of Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany.; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University, Heidelberg, Germany., Zaoui K; Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg University Hospital, Heidelberg, Germany., Federspil PA; Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg University Hospital, Heidelberg, Germany., Adeberg S; German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.; Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany.; Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg, Germany., Linge A; Clinical Cooperation Unit Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital (UKHD), Heidelberg, Germany.; German Cancer Consortium (DKTK), Partner Site Dresden, Dresden, Germany.; Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; National Center for Tumor Diseases (NCT), Partner Site Dresden, Dresden, Germany.; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany., Ganswindt U; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany.; Department of Radiation Oncology, Medical University of Innsbruck, Innsbruck, Austria., Hess J; Department of Radiation Oncology, University Hospital Ludwig-Maximilians-University of Munich, Munich, Germany.; Research Unit Radiation Cytogenetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany.; Clinical Cooperation Group 'Personalized Radiotherapy in Head and Neck Cancer', Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany., Unger K; Department of Radiation Oncology, University Hospital Ludwig-Maximilians-University of Munich, Munich, Germany.; Research Unit Radiation Cytogenetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany.; Clinical Cooperation Group 'Personalized Radiotherapy in Head and Neck Cancer', Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany., Tinhofer I; German Cancer Consortium (DKTK), Partner Site Berlin, Berlin, Germany.; Department of Radiooncology and Radiotherapy, Charité University Hospital, Berlin, Germany., Budach V; German Cancer Consortium (DKTK), Partner Site Berlin, Berlin, Germany.; Department of Radiooncology and Radiotherapy, Charité University Hospital, Berlin, Germany., Lohaus F; Clinical Cooperation Unit Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital (UKHD), Heidelberg, Germany.; German Cancer Consortium (DKTK), Partner Site Dresden, Dresden, Germany.; Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; National Center for Tumor Diseases (NCT), Partner Site Dresden, Dresden, Germany.; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany., Krause M; Clinical Cooperation Unit Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital (UKHD), Heidelberg, Germany.; German Cancer Consortium (DKTK), Partner Site Dresden, Dresden, Germany.; Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; National Center for Tumor Diseases (NCT), Partner Site Dresden, Dresden, Germany.; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany., Guberina M; German Cancer Consortium (DKTK), Partner Site Essen, Essen, Germany.; Department of Radiotherapy, Medical Faculty, University of Duisburg-Essen, Essen, Germany., Stuschke M; Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; Department of Radiotherapy, Medical Faculty, University of Duisburg-Essen, Essen, Germany., Balermpas P; German Cancer Consortium (DKTK), Partner Site Frankfurt, Frankfurt, Germany.; Department of Radiation Oncology, University Hospital Zurich, Zurich, Switzerland., Rödel C; German Cancer Consortium (DKTK), Partner Site Frankfurt, Frankfurt, Germany.; Department of Radiotherapy and Oncology, Goethe-University Frankfurt, Frankfurt, Germany., Grosu AL; German Cancer Consortium (DKTK), Partner Site Freiburg, Freiburg, Germany.; Department of Radiation Oncology, Clinical Study Section, University of Freiburg, Freiburg, Germany.; Department of Radiation Oncology, University of Freiburg, Freiburg, Germany., Schäfer H; German Cancer Consortium (DKTK), Partner Site Freiburg, Freiburg, Germany.; Department of Radiation Oncology, Clinical Study Section, University of Freiburg, Freiburg, Germany., Zips D; German Cancer Consortium (DKTK), Partner Site Tuebingen, Tuebingen, Germany.; Department of Radiation Oncology, Faculty of Medicine and University Hospital Tübingen, Eberhard Karls Universität Tübingen, Tübingen, Germany., Combs SE; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany.; Department of Radiation Oncology, Technische Universität München, Munich, Germany., Pigorsch S; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany.; Department of Radiation Oncology, Technische Universität München, Munich, Germany., Zitzelsberger H; Department of Radiation Oncology, University Hospital Ludwig-Maximilians-University of Munich, Munich, Germany.; Research Unit Radiation Cytogenetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany.; Clinical Cooperation Group 'Personalized Radiotherapy in Head and Neck Cancer', Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany., Baumeister P; Research Unit Radiation Cytogenetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany.; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital, Ludwig-Maximilians-University of Munich, Munich, Germany., Kirchner T; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany.; Institute of Pathology, Faculty of Medicine, Ludwig-Maximilians-University of Munich, Munich, Germany., Bewerunge-Hudler M; Genomics and Proteomics Core Facility, German Cancer Research Center, Heidelberg, Germany., Weichert W; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany.; Institute of Pathology, Technische Universität München, Munich, Germany., Hess J; Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg University Hospital, Heidelberg, Germany.; Department of Molecular Mechanisms of Head and Neck Tumors, German Cancer Research Center, Heidelberg, Germany., Herpel E; German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.; Tissue Bank, National Center for Tumor Diseases (NCT), Heidelberg, Germany.; Department of Applied Tumor Biology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany., Belka C; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany.; Department of Radiation Oncology, University Hospital Ludwig-Maximilians-University of Munich, Munich, Germany.; Research Unit Radiation Cytogenetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany., Baumann M; German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.; German Cancer Consortium (DKTK), Partner Site Dresden, Dresden, Germany.; Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Debus J; German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital (UKHD), Heidelberg, Germany.; Division of Molecular and Translational Radiation Oncology, Department of Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany.; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University, Heidelberg, Germany., Abdollahi A; German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital (UKHD), Heidelberg, Germany.; Division of Molecular and Translational Radiation Oncology, Department of Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany.; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University, Heidelberg, Germany. |
| Corporate Authors: | DKTK-ROG |
| Source: | International journal of cancer [Int J Cancer] 2022 Feb 15; Vol. 150 (4), pp. 603-616. Date of Electronic Publication: 2021 Nov 08. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0042124 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0215 (Electronic) Linking ISSN: 00207136 NLM ISO Abbreviation: Int J Cancer Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
|
Full text is not displayed to guests.
Login for full access.
|
|
| ISSN: | 1097-0215 |
|---|---|
| DOI: | 10.1002/ijc.33842 |
