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A Conservative Point Mutation in a Dynamic Antigen-binding Loop of Human Immunoglobulin λ6 Light Chain Promotes Pathologic Amyloid Formation.

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Title: A Conservative Point Mutation in a Dynamic Antigen-binding Loop of Human Immunoglobulin λ6 Light Chain Promotes Pathologic Amyloid Formation.
Authors: Peterle D; Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, United States. Electronic address: d.peterle@northeastern.edu., Klimtchuk ES; Amyloidosis Center, Boston University School of Medicine, Boston, MA 02118, United States. Electronic address: klimtchu@bu.edu., Wales TE; Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, United States. Electronic address: T.Wales@northeastern.edu., Georgescauld F; Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, United States., Connors LH; Amyloidosis Center, Boston University School of Medicine, Boston, MA 02118, United States. Electronic address: lconnors@bu.edu., Engen JR; Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, United States. Electronic address: J.Engen@northeastern.edu., Gursky O; Amyloidosis Center, Boston University School of Medicine, Boston, MA 02118, United States; Department of Physiology & Biophysics, Boston University School of Medicine, 700 Albany Street, Boston, MA 02118, United States. Electronic address: Gursky@bu.edu.
Source: Journal of molecular biology [J Mol Biol] 2021 Dec 03; Vol. 433 (24), pp. 167310. Date of Electronic Publication: 2021 Oct 19.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A Conservative Point Mutation in a Dynamic Antigen-binding Loop of Human Immunoglobulin λ6 Light Chain Promotes Pathologic Amyloid Formation.
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  Data: <searchLink fieldCode="AU" term="%22Peterle+D%22">Peterle D</searchLink>; Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, United States. Electronic address: d.peterle@northeastern.edu.<br /><searchLink fieldCode="AU" term="%22Klimtchuk+ES%22">Klimtchuk ES</searchLink>; Amyloidosis Center, Boston University School of Medicine, Boston, MA 02118, United States. Electronic address: klimtchu@bu.edu.<br /><searchLink fieldCode="AU" term="%22Wales+TE%22">Wales TE</searchLink>; Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, United States. Electronic address: T.Wales@northeastern.edu.<br /><searchLink fieldCode="AU" term="%22Georgescauld+F%22">Georgescauld F</searchLink>; Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, United States.<br /><searchLink fieldCode="AU" term="%22Connors+LH%22">Connors LH</searchLink>; Amyloidosis Center, Boston University School of Medicine, Boston, MA 02118, United States. Electronic address: lconnors@bu.edu.<br /><searchLink fieldCode="AU" term="%22Engen+JR%22">Engen JR</searchLink>; Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, United States. Electronic address: J.Engen@northeastern.edu.<br /><searchLink fieldCode="AU" term="%22Gursky+O%22">Gursky O</searchLink>; Amyloidosis Center, Boston University School of Medicine, Boston, MA 02118, United States; Department of Physiology & Biophysics, Boston University School of Medicine, 700 Albany Street, Boston, MA 02118, United States. Electronic address: Gursky@bu.edu.
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              Text: 2021 Dec 03
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