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Deep-learning-based synthesis of post-contrast T1-weighted MRI for tumour response assessment in neuro-oncology: a multicentre, retrospective cohort study.

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Title: Deep-learning-based synthesis of post-contrast T1-weighted MRI for tumour response assessment in neuro-oncology: a multicentre, retrospective cohort study.
Authors: Jayachandran Preetha C; Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany., Meredig H; Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany., Brugnara G; Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany., Mahmutoglu MA; Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany., Foltyn M; Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany., Isensee F; Medical Image Computing, German Cancer Research Center, Heidelberg, Germany., Kessler T; Neurology Clinic, Heidelberg University Hospital, Heidelberg, Germany; Clinical Cooperation Unit Neurooncology, German Cancer Research Center, Heidelberg, Germany., Pflüger I; Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany., Schell M; Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany., Neuberger U; Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany., Petersen J; Medical Image Computing, German Cancer Research Center, Heidelberg, Germany., Wick A; Neurology Clinic, Heidelberg University Hospital, Heidelberg, Germany., Heiland S; Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany., Debus J; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany; Heidelberg Institute of Radiation Oncology, Heidelberg, Germany; Heidelberg Ion-Beam Therapy Center, Heidelberg, Germany., Platten M; Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center, Heidelberg, Germany; Department of Neurology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Idbaih A; Sorbonne Université, Inserm, Institut du Cerveau, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, Service de Neurologie 2-Mazarin, Paris, France., Brandes AA; Department of Medical Oncology, Azienda USL of Bologna, Bologna, Italy., Winkler F; Neurology Clinic, Heidelberg University Hospital, Heidelberg, Germany; Clinical Cooperation Unit Neurooncology, German Cancer Research Center, Heidelberg, Germany., van den Bent MJ; Brain Tumor Center, Erasmus MC Cancer Institute, Rotterdam, Netherlands., Nabors B; Department of Neurology and O'Neal Comprehensive Cancer Center, Division of Neuro-Oncology, University of Alabama at Birmingham, Birmingham, AL, USA., Stupp R; Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Department of Neurological Surgery and Department of Neurology, Northwestern Medicine and Northwestern University, Chicago, IL, USA., Maier-Hein KH; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany; Medical Image Computing, German Cancer Research Center, Heidelberg, Germany., Gorlia T; European Organisation for Research and Treatment of Cancer, Brussels, Belgium., Tonn JC; Department of Neurosurgery, Ludwig-Maximilians-University, Munich, Germany., Weller M; Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland., Wick W; Neurology Clinic, Heidelberg University Hospital, Heidelberg, Germany; Clinical Cooperation Unit Neurooncology, German Cancer Research Center, Heidelberg, Germany., Bendszus M; Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany., Vollmuth P; Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany. Electronic address: philipp.vollmuth@med.uni-heidelberg.de.
Source: The Lancet. Digital health [Lancet Digit Health] 2021 Dec; Vol. 3 (12), pp. e784-e794. Date of Electronic Publication: 2021 Oct 20.
Publication Type: Clinical Trial, Phase II; Clinical Trial, Phase III; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101751302 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2589-7500 (Electronic) Linking ISSN: 25897500 NLM ISO Abbreviation: Lancet Digit Health Subsets: MEDLINE
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  Data: Deep-learning-based synthesis of post-contrast T1-weighted MRI for tumour response assessment in neuro-oncology: a multicentre, retrospective cohort study.
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  Data: <searchLink fieldCode="AU" term="%22Jayachandran+Preetha+C%22">Jayachandran Preetha C</searchLink>; Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Meredig+H%22">Meredig H</searchLink>; Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Brugnara+G%22">Brugnara G</searchLink>; Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Mahmutoglu+MA%22">Mahmutoglu MA</searchLink>; Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Foltyn+M%22">Foltyn M</searchLink>; Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Isensee+F%22">Isensee F</searchLink>; Medical Image Computing, German Cancer Research Center, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Kessler+T%22">Kessler T</searchLink>; Neurology Clinic, Heidelberg University Hospital, Heidelberg, Germany; Clinical Cooperation Unit Neurooncology, German Cancer Research Center, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Pflüger+I%22">Pflüger I</searchLink>; Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Schell+M%22">Schell M</searchLink>; Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Neuberger+U%22">Neuberger U</searchLink>; Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Petersen+J%22">Petersen J</searchLink>; Medical Image Computing, German Cancer Research Center, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Wick+A%22">Wick A</searchLink>; Neurology Clinic, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Heiland+S%22">Heiland S</searchLink>; Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Debus+J%22">Debus J</searchLink>; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany; Heidelberg Institute of Radiation Oncology, Heidelberg, Germany; Heidelberg Ion-Beam Therapy Center, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Platten+M%22">Platten M</searchLink>; Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center, Heidelberg, Germany; Department of Neurology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Idbaih+A%22">Idbaih A</searchLink>; Sorbonne Université, Inserm, Institut du Cerveau, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, Service de Neurologie 2-Mazarin, Paris, France.<br /><searchLink fieldCode="AU" term="%22Brandes+AA%22">Brandes AA</searchLink>; Department of Medical Oncology, Azienda USL of Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Winkler+F%22">Winkler F</searchLink>; Neurology Clinic, Heidelberg University Hospital, Heidelberg, Germany; Clinical Cooperation Unit Neurooncology, German Cancer Research Center, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22van+den+Bent+MJ%22">van den Bent MJ</searchLink>; Brain Tumor Center, Erasmus MC Cancer Institute, Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Nabors+B%22">Nabors B</searchLink>; Department of Neurology and O'Neal Comprehensive Cancer Center, Division of Neuro-Oncology, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Stupp+R%22">Stupp R</searchLink>; Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Department of Neurological Surgery and Department of Neurology, Northwestern Medicine and Northwestern University, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Maier-Hein+KH%22">Maier-Hein KH</searchLink>; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany; Medical Image Computing, German Cancer Research Center, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Gorlia+T%22">Gorlia T</searchLink>; European Organisation for Research and Treatment of Cancer, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Tonn+JC%22">Tonn JC</searchLink>; Department of Neurosurgery, Ludwig-Maximilians-University, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Weller+M%22">Weller M</searchLink>; Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Wick+W%22">Wick W</searchLink>; Neurology Clinic, Heidelberg University Hospital, Heidelberg, Germany; Clinical Cooperation Unit Neurooncology, German Cancer Research Center, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Bendszus+M%22">Bendszus M</searchLink>; Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Vollmuth+P%22">Vollmuth P</searchLink>; Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany. Electronic address: philipp.vollmuth@med.uni-heidelberg.de.
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  Data: <searchLink fieldCode="JN" term="%22101751302%22">The Lancet. Digital health</searchLink> [Lancet Digit Health] 2021 Dec; Vol. 3 (12), pp. e784-e794. <i>Date of Electronic Publication: </i>2021 Oct 20.
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