Thermodynamic Understanding of an Aza-Michael Reaction Enables Five-Step Synthesis of the Potent Integrin Inhibitor MK-0429.

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Bibliographic Details
Title: Thermodynamic Understanding of an Aza-Michael Reaction Enables Five-Step Synthesis of the Potent Integrin Inhibitor MK-0429.
Authors: Gupta A; Department of Small Molecule Drug Discovery, Bristol Myers Squibb Company, 100 Binney Street, Cambridge, Massachusetts 02142, United States., Condakes ML; Department of Small Molecule Drug Discovery, Bristol Myers Squibb Company, 100 Binney Street, Cambridge, Massachusetts 02142, United States.
Source: The Journal of organic chemistry [J Org Chem] 2021 Dec 03; Vol. 86 (23), pp. 17523-17527. Date of Electronic Publication: 2021 Nov 01.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 2985193R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6904 (Electronic) Linking ISSN: 00223263 NLM ISO Abbreviation: J Org Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-6904
DOI:10.1021/acs.joc.1c02375