Diverse alterations associated with resistance to KRAS(G12C) inhibition.

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Title: Diverse alterations associated with resistance to KRAS(G12C) inhibition.
Authors: Zhao Y; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer, New York, NY, USA., Murciano-Goroff YR; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Xue JY; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer, New York, NY, USA.; Weill Cornell-Rockefeller-Sloan Kettering Tri-Institutional MD-PhD Program, New York, NY, USA., Ang A; Amgen, Thousand Oaks, CA, USA., Lucas J; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer, New York, NY, USA., Mai TT; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer, New York, NY, USA., Da Cruz Paula AF; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Saiki AY; Amgen, Thousand Oaks, CA, USA., Mohn D; Amgen, Thousand Oaks, CA, USA., Achanta P; Amgen, Thousand Oaks, CA, USA., Sisk AE; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Arora KS; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Roy RS; Weill Cornell-Rockefeller-Sloan Kettering Tri-Institutional MD-PhD Program, New York, NY, USA., Kim D; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer, New York, NY, USA., Li C; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer, New York, NY, USA., Lim LP; Resolution Bioscience, Kirkland, WA, USA., Li M; Resolution Bioscience, Kirkland, WA, USA., Bahr A; Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Loomis BR; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., de Stanchina E; Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Reis-Filho JS; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Weigelt B; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Berger M; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Riely G; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Arbour KC; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Lipford JR; Amgen, Thousand Oaks, CA, USA., Li BT; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Lito P; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer, New York, NY, USA. litop@mskcc.org.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. litop@mskcc.org.; Weill Cornell-Rockefeller-Sloan Kettering Tri-Institutional MD-PhD Program, New York, NY, USA. litop@mskcc.org.; Department of Medicine, Weill Cornell Medical College, New York, NY, USA. litop@mskcc.org.
Source: Nature [Nature] 2021 Nov; Vol. 599 (7886), pp. 679-683. Date of Electronic Publication: 2021 Nov 10.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Zhao+Y%22">Zhao Y</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Murciano-Goroff+YR%22">Murciano-Goroff YR</searchLink>; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Xue+JY%22">Xue JY</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer, New York, NY, USA.; Weill Cornell-Rockefeller-Sloan Kettering Tri-Institutional MD-PhD Program, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ang+A%22">Ang A</searchLink>; Amgen, Thousand Oaks, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lucas+J%22">Lucas J</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Mai+TT%22">Mai TT</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Da+Cruz+Paula+AF%22">Da Cruz Paula AF</searchLink>; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Saiki+AY%22">Saiki AY</searchLink>; Amgen, Thousand Oaks, CA, USA.<br /><searchLink fieldCode="AU" term="%22Mohn+D%22">Mohn D</searchLink>; Amgen, Thousand Oaks, CA, USA.<br /><searchLink fieldCode="AU" term="%22Achanta+P%22">Achanta P</searchLink>; Amgen, Thousand Oaks, CA, USA.<br /><searchLink fieldCode="AU" term="%22Sisk+AE%22">Sisk AE</searchLink>; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Arora+KS%22">Arora KS</searchLink>; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Roy+RS%22">Roy RS</searchLink>; Weill Cornell-Rockefeller-Sloan Kettering Tri-Institutional MD-PhD Program, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kim+D%22">Kim D</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Li+C%22">Li C</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lim+LP%22">Lim LP</searchLink>; Resolution Bioscience, Kirkland, WA, USA.<br /><searchLink fieldCode="AU" term="%22Li+M%22">Li M</searchLink>; Resolution Bioscience, Kirkland, WA, USA.<br /><searchLink fieldCode="AU" term="%22Bahr+A%22">Bahr A</searchLink>; Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Loomis+BR%22">Loomis BR</searchLink>; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22de+Stanchina+E%22">de Stanchina E</searchLink>; Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Reis-Filho+JS%22">Reis-Filho JS</searchLink>; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Weigelt+B%22">Weigelt B</searchLink>; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Berger+M%22">Berger M</searchLink>; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Riely+G%22">Riely G</searchLink>; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Arbour+KC%22">Arbour KC</searchLink>; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lipford+JR%22">Lipford JR</searchLink>; Amgen, Thousand Oaks, CA, USA.<br /><searchLink fieldCode="AU" term="%22Li+BT%22">Li BT</searchLink>; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lito+P%22">Lito P</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer, New York, NY, USA. litop@mskcc.org.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. litop@mskcc.org.; Weill Cornell-Rockefeller-Sloan Kettering Tri-Institutional MD-PhD Program, New York, NY, USA. litop@mskcc.org.; Department of Medicine, Weill Cornell Medical College, New York, NY, USA. litop@mskcc.org.
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  Data: <searchLink fieldCode="JN" term="%220410462%22">Nature</searchLink> [Nature] 2021 Nov; Vol. 599 (7886), pp. 679-683. <i>Date of Electronic Publication: </i>2021 Nov 10.
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