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New Hybrid Compounds Combining Fragments of Usnic Acid and Thioether Are Inhibitors of Human Enzymes TDP1, TDP2 and PARP1.

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Title: New Hybrid Compounds Combining Fragments of Usnic Acid and Thioether Are Inhibitors of Human Enzymes TDP1, TDP2 and PARP1.
Authors: Dyrkheeva NS; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia., Filimonov AS; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia., Luzina OA; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia., Orlova KA; Department of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia., Chernyshova IA; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia., Kornienko TE; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia., Malakhova AA; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.; Federal Research Centre Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia., Medvedev SP; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.; Federal Research Centre Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia., Zakharenko AL; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.; Department of Physical and Chemical Biology and Biotechnology, Altai State University, 656049 Barnaul, Russia., Ilina ES; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia., Anarbaev RO; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia., Naumenko KN; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia., Klabenkova KV; Department of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia.; Federal Research Centre Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia., Burakova EA; Department of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia.; Federal Research Centre Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia., Stetsenko DA; Department of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia.; Federal Research Centre Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia., Zakian SM; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.; Federal Research Centre Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia., Salakhutdinov NF; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia., Lavrik OI; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.; Department of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia.; Department of Physical and Chemical Biology and Biotechnology, Altai State University, 656049 Barnaul, Russia.
Source: International journal of molecular sciences [Int J Mol Sci] 2021 Oct 20; Vol. 22 (21). Date of Electronic Publication: 2021 Oct 20.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
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  Data: New Hybrid Compounds Combining Fragments of Usnic Acid and Thioether Are Inhibitors of Human Enzymes TDP1, TDP2 and PARP1.
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  Data: <searchLink fieldCode="AU" term="%22Dyrkheeva+NS%22">Dyrkheeva NS</searchLink>; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.<br /><searchLink fieldCode="AU" term="%22Filimonov+AS%22">Filimonov AS</searchLink>; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.<br /><searchLink fieldCode="AU" term="%22Luzina+OA%22">Luzina OA</searchLink>; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.<br /><searchLink fieldCode="AU" term="%22Orlova+KA%22">Orlova KA</searchLink>; Department of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia.<br /><searchLink fieldCode="AU" term="%22Chernyshova+IA%22">Chernyshova IA</searchLink>; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.<br /><searchLink fieldCode="AU" term="%22Kornienko+TE%22">Kornienko TE</searchLink>; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.<br /><searchLink fieldCode="AU" term="%22Malakhova+AA%22">Malakhova AA</searchLink>; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.; Federal Research Centre Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.<br /><searchLink fieldCode="AU" term="%22Medvedev+SP%22">Medvedev SP</searchLink>; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.; Federal Research Centre Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.<br /><searchLink fieldCode="AU" term="%22Zakharenko+AL%22">Zakharenko AL</searchLink>; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.; Department of Physical and Chemical Biology and Biotechnology, Altai State University, 656049 Barnaul, Russia.<br /><searchLink fieldCode="AU" term="%22Ilina+ES%22">Ilina ES</searchLink>; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.<br /><searchLink fieldCode="AU" term="%22Anarbaev+RO%22">Anarbaev RO</searchLink>; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.<br /><searchLink fieldCode="AU" term="%22Naumenko+KN%22">Naumenko KN</searchLink>; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.<br /><searchLink fieldCode="AU" term="%22Klabenkova+KV%22">Klabenkova KV</searchLink>; Department of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia.; Federal Research Centre Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.<br /><searchLink fieldCode="AU" term="%22Burakova+EA%22">Burakova EA</searchLink>; Department of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia.; Federal Research Centre Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.<br /><searchLink fieldCode="AU" term="%22Stetsenko+DA%22">Stetsenko DA</searchLink>; Department of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia.; Federal Research Centre Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.<br /><searchLink fieldCode="AU" term="%22Zakian+SM%22">Zakian SM</searchLink>; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.; Federal Research Centre Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.<br /><searchLink fieldCode="AU" term="%22Salakhutdinov+NF%22">Salakhutdinov NF</searchLink>; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.<br /><searchLink fieldCode="AU" term="%22Lavrik+OI%22">Lavrik OI</searchLink>; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.; Department of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia.; Department of Physical and Chemical Biology and Biotechnology, Altai State University, 656049 Barnaul, Russia.
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        Value: 10.3390/ijms222111336
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