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Chk1 Inhibition Potently Blocks STAT3 Tyrosine705 Phosphorylation, DNA-Binding Activity, and Activation of Downstream Targets in Human Multiple Myeloma Cells.

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Title: Chk1 Inhibition Potently Blocks STAT3 Tyrosine705 Phosphorylation, DNA-Binding Activity, and Activation of Downstream Targets in Human Multiple Myeloma Cells.
Authors: Zhou L; Division of Hematology/Oncology, Department of Medicine, Virginia Commonwealth University, Richmond, Virginia., Pei X; Division of Hematology/Oncology, Department of Medicine, Virginia Commonwealth University, Richmond, Virginia., Zhang Y; Division of Hematology/Oncology, Department of Medicine, Virginia Commonwealth University, Richmond, Virginia.; Division of Molecular Diagnostics, Department of Pathology, Virginia Commonwealth University, Richmond, Virginia., Ning Y; Division of Hematology/Oncology, Department of Medicine, Virginia Commonwealth University, Richmond, Virginia., Li L; Division of Hematology/Oncology, Department of Medicine, Virginia Commonwealth University, Richmond, Virginia., Hu X; Division of Hematology/Oncology, Department of Medicine, Virginia Commonwealth University, Richmond, Virginia., Chalasani SL; Division of Hematology/Oncology, Department of Medicine, Virginia Commonwealth University, Richmond, Virginia., Sharma K; Division of Hematology/Oncology, Department of Medicine, Virginia Commonwealth University, Richmond, Virginia., Nkwocha J; Division of Hematology/Oncology, Department of Medicine, Virginia Commonwealth University, Richmond, Virginia., Yu J; Biology Department, University of Virginia, Charlottesville, Virginia., Bandyopadhyay D; Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia.; Department of Biostatistics, Virginia Commonwealth University, Richmond, Virginia., Sebti SM; Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia.; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia., Grant S; Division of Hematology/Oncology, Department of Medicine, Virginia Commonwealth University, Richmond, Virginia.; Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia.
Source: Molecular cancer research : MCR [Mol Cancer Res] 2022 Mar 01; Vol. 20 (3), pp. 456-467.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101150042 Publication Model: Print Cited Medium: Internet ISSN: 1557-3125 (Electronic) Linking ISSN: 15417786 NLM ISO Abbreviation: Mol Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Chk1 Inhibition Potently Blocks STAT3 Tyrosine705 Phosphorylation, DNA-Binding Activity, and Activation of Downstream Targets in Human Multiple Myeloma Cells.
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  Data: <searchLink fieldCode="AU" term="%22Zhou+L%22">Zhou L</searchLink>; Division of Hematology/Oncology, Department of Medicine, Virginia Commonwealth University, Richmond, Virginia.<br /><searchLink fieldCode="AU" term="%22Pei+X%22">Pei X</searchLink>; Division of Hematology/Oncology, Department of Medicine, Virginia Commonwealth University, Richmond, Virginia.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Division of Hematology/Oncology, Department of Medicine, Virginia Commonwealth University, Richmond, Virginia.; Division of Molecular Diagnostics, Department of Pathology, Virginia Commonwealth University, Richmond, Virginia.<br /><searchLink fieldCode="AU" term="%22Ning+Y%22">Ning Y</searchLink>; Division of Hematology/Oncology, Department of Medicine, Virginia Commonwealth University, Richmond, Virginia.<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; Division of Hematology/Oncology, Department of Medicine, Virginia Commonwealth University, Richmond, Virginia.<br /><searchLink fieldCode="AU" term="%22Hu+X%22">Hu X</searchLink>; Division of Hematology/Oncology, Department of Medicine, Virginia Commonwealth University, Richmond, Virginia.<br /><searchLink fieldCode="AU" term="%22Chalasani+SL%22">Chalasani SL</searchLink>; Division of Hematology/Oncology, Department of Medicine, Virginia Commonwealth University, Richmond, Virginia.<br /><searchLink fieldCode="AU" term="%22Sharma+K%22">Sharma K</searchLink>; Division of Hematology/Oncology, Department of Medicine, Virginia Commonwealth University, Richmond, Virginia.<br /><searchLink fieldCode="AU" term="%22Nkwocha+J%22">Nkwocha J</searchLink>; Division of Hematology/Oncology, Department of Medicine, Virginia Commonwealth University, Richmond, Virginia.<br /><searchLink fieldCode="AU" term="%22Yu+J%22">Yu J</searchLink>; Biology Department, University of Virginia, Charlottesville, Virginia.<br /><searchLink fieldCode="AU" term="%22Bandyopadhyay+D%22">Bandyopadhyay D</searchLink>; Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia.; Department of Biostatistics, Virginia Commonwealth University, Richmond, Virginia.<br /><searchLink fieldCode="AU" term="%22Sebti+SM%22">Sebti SM</searchLink>; Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia.; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia.<br /><searchLink fieldCode="AU" term="%22Grant+S%22">Grant S</searchLink>; Division of Hematology/Oncology, Department of Medicine, Virginia Commonwealth University, Richmond, Virginia.; Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia.
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  Data: <searchLink fieldCode="JN" term="%22101150042%22">Molecular cancer research : MCR</searchLink> [Mol Cancer Res] 2022 Mar 01; Vol. 20 (3), pp. 456-467.
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