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Antisense therapy in a rat model of Alexander disease reverses GFAP pathology, white matter deficits, and motor impairment.

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Title: Antisense therapy in a rat model of Alexander disease reverses GFAP pathology, white matter deficits, and motor impairment.
Authors: Hagemann TL; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA., Powers B; Ionis Pharmaceuticals, Carlsbad, CA 92010, USA., Lin NH; Institute of Molecular Medicine, College of Life Sciences, National Tsing Hua University, Hsinchu 30013, Taiwan., Mohamed AF; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA., Dague KL; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA., Hannah SC; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA., Bachmann G; Ionis Pharmaceuticals, Carlsbad, CA 92010, USA., Mazur C; Ionis Pharmaceuticals, Carlsbad, CA 92010, USA., Rigo F; Ionis Pharmaceuticals, Carlsbad, CA 92010, USA., Olsen AL; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Feany MB; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Perng MD; Institute of Molecular Medicine, College of Life Sciences, National Tsing Hua University, Hsinchu 30013, Taiwan., Berman RF; Department of Neurological Surgery and M.I.N.D Institute, University of California, Davis, Davis, CA 95616, USA., Messing A; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.; Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA.
Source: Science translational medicine [Sci Transl Med] 2021 Nov 17; Vol. 13 (620), pp. eabg4711. Date of Electronic Publication: 2021 Nov 17.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Antisense therapy in a rat model of Alexander disease reverses GFAP pathology, white matter deficits, and motor impairment.
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  Data: <searchLink fieldCode="AU" term="%22Hagemann+TL%22">Hagemann TL</searchLink>; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.<br /><searchLink fieldCode="AU" term="%22Powers+B%22">Powers B</searchLink>; Ionis Pharmaceuticals, Carlsbad, CA 92010, USA.<br /><searchLink fieldCode="AU" term="%22Lin+NH%22">Lin NH</searchLink>; Institute of Molecular Medicine, College of Life Sciences, National Tsing Hua University, Hsinchu 30013, Taiwan.<br /><searchLink fieldCode="AU" term="%22Mohamed+AF%22">Mohamed AF</searchLink>; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.<br /><searchLink fieldCode="AU" term="%22Dague+KL%22">Dague KL</searchLink>; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.<br /><searchLink fieldCode="AU" term="%22Hannah+SC%22">Hannah SC</searchLink>; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.<br /><searchLink fieldCode="AU" term="%22Bachmann+G%22">Bachmann G</searchLink>; Ionis Pharmaceuticals, Carlsbad, CA 92010, USA.<br /><searchLink fieldCode="AU" term="%22Mazur+C%22">Mazur C</searchLink>; Ionis Pharmaceuticals, Carlsbad, CA 92010, USA.<br /><searchLink fieldCode="AU" term="%22Rigo+F%22">Rigo F</searchLink>; Ionis Pharmaceuticals, Carlsbad, CA 92010, USA.<br /><searchLink fieldCode="AU" term="%22Olsen+AL%22">Olsen AL</searchLink>; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Feany+MB%22">Feany MB</searchLink>; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Perng+MD%22">Perng MD</searchLink>; Institute of Molecular Medicine, College of Life Sciences, National Tsing Hua University, Hsinchu 30013, Taiwan.<br /><searchLink fieldCode="AU" term="%22Berman+RF%22">Berman RF</searchLink>; Department of Neurological Surgery and M.I.N.D Institute, University of California, Davis, Davis, CA 95616, USA.<br /><searchLink fieldCode="AU" term="%22Messing+A%22">Messing A</searchLink>; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.; Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2021 Nov 17; Vol. 13 (620), pp. eabg4711. <i>Date of Electronic Publication: </i>2021 Nov 17.
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