Antisense therapy in a rat model of Alexander disease reverses GFAP pathology, white matter deficits, and motor impairment.
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| Title: | Antisense therapy in a rat model of Alexander disease reverses GFAP pathology, white matter deficits, and motor impairment. |
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| Authors: | Hagemann TL; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA., Powers B; Ionis Pharmaceuticals, Carlsbad, CA 92010, USA., Lin NH; Institute of Molecular Medicine, College of Life Sciences, National Tsing Hua University, Hsinchu 30013, Taiwan., Mohamed AF; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA., Dague KL; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA., Hannah SC; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA., Bachmann G; Ionis Pharmaceuticals, Carlsbad, CA 92010, USA., Mazur C; Ionis Pharmaceuticals, Carlsbad, CA 92010, USA., Rigo F; Ionis Pharmaceuticals, Carlsbad, CA 92010, USA., Olsen AL; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Feany MB; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Perng MD; Institute of Molecular Medicine, College of Life Sciences, National Tsing Hua University, Hsinchu 30013, Taiwan., Berman RF; Department of Neurological Surgery and M.I.N.D Institute, University of California, Davis, Davis, CA 95616, USA., Messing A; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.; Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA. |
| Source: | Science translational medicine [Sci Transl Med] 2021 Nov 17; Vol. 13 (620), pp. eabg4711. Date of Electronic Publication: 2021 Nov 17. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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