MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA.
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| Title: | MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA. |
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| Authors: | Yu Q; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge, CB2 0QH, UK.; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge School of Clinical Medicine, Cambridge, CB2 0AW, UK.; Institute of Molecular Biology and Biophysics, Department of Biology, ETH Zürich, Zürich, Switzerland., Herrero Del Valle A; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge, CB2 0QH, UK.; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge School of Clinical Medicine, Cambridge, CB2 0AW, UK., Singh R; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge, CB2 0QH, UK.; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge School of Clinical Medicine, Cambridge, CB2 0AW, UK., Modis Y; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge, CB2 0QH, UK. ymodis@mrc-lmb.cam.ac.uk.; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge School of Clinical Medicine, Cambridge, CB2 0AW, UK. ymodis@mrc-lmb.cam.ac.uk. |
| Source: | Nature communications [Nat Commun] 2021 Nov 18; Vol. 12 (1), pp. 6668. Date of Electronic Publication: 2021 Nov 18. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 34795277 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Yu+Q%22">Yu Q</searchLink>; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge, CB2 0QH, UK.; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge School of Clinical Medicine, Cambridge, CB2 0AW, UK.; Institute of Molecular Biology and Biophysics, Department of Biology, ETH Zürich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Herrero+Del+Valle+A%22">Herrero Del Valle A</searchLink>; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge, CB2 0QH, UK.; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge School of Clinical Medicine, Cambridge, CB2 0AW, UK.<br /><searchLink fieldCode="AU" term="%22Singh+R%22">Singh R</searchLink>; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge, CB2 0QH, UK.; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge School of Clinical Medicine, Cambridge, CB2 0AW, UK.<br /><searchLink fieldCode="AU" term="%22Modis+Y%22">Modis Y</searchLink>; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge, CB2 0QH, UK. ymodis@mrc-lmb.cam.ac.uk.; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge School of Clinical Medicine, Cambridge, CB2 0AW, UK. ymodis@mrc-lmb.cam.ac.uk. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2021 Nov 18; Vol. 12 (1), pp. 6668. <i>Date of Electronic Publication: </i>2021 Nov 18. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101528555 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-1723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220411723%22">20411723 </searchLink><i>NLM ISO Abbreviation: </i>Nat Commun <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=34795277 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41467-021-27062-5 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 6668 Titles: – TitleFull: MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Yu Q – PersonEntity: Name: NameFull: Herrero Del Valle A – PersonEntity: Name: NameFull: Singh R – PersonEntity: Name: NameFull: Modis Y IsPartOfRelationships: – BibEntity: Dates: – D: 18 M: 11 Text: 2021 Nov 18 Type: published Y: 2021 Identifiers: – Type: issn-electronic Value: 2041-1723 Numbering: – Type: volume Value: 12 – Type: issue Value: 1 Titles: – TitleFull: Nature communications Type: main |
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