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Dynamic CD4+ T cell heterogeneity defines subset-specific suppression and PD-L1-blockade-driven functional restoration in chronic infection.

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Title: Dynamic CD4+ T cell heterogeneity defines subset-specific suppression and PD-L1-blockade-driven functional restoration in chronic infection.
Authors: Snell LM; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. lausnell@iu.edu.; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA. lausnell@iu.edu., Xu W; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Abd-Rabbo D; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Boukhaled G; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Guo M; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Immunology, University of Toronto, Toronto, ON, Canada., Macleod BL; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Elsaesser HJ; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Hezaveh K; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Alsahafi N; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Lukhele S; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Nejat S; Toronto General Hospital Research Institute, University Health Network (UHN), Toronto, ON, Canada., Prabhakaran R; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Epelman S; Department of Immunology, University of Toronto, Toronto, ON, Canada.; Toronto General Hospital Research Institute, University Health Network (UHN), Toronto, ON, Canada.; Peter Munk Cardiac Centre, Ted Rogers Centre for Heart Research, Toronto, ON, Canada., McGaha TL; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Immunology, University of Toronto, Toronto, ON, Canada., Brooks DG; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. dbrooks@uhnresearch.ca.; Department of Immunology, University of Toronto, Toronto, ON, Canada. dbrooks@uhnresearch.ca.
Source: Nature immunology [Nat Immunol] 2021 Dec; Vol. 22 (12), pp. 1524-1537. Date of Electronic Publication: 2021 Nov 18.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
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  Data: Dynamic CD4<superscript>+</superscript> T cell heterogeneity defines subset-specific suppression and PD-L1-blockade-driven functional restoration in chronic infection.
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