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Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis.

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Title: Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis.
Authors: Meng Y; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia., Davies KA; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia., Fitzgibbon C; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia., Young SN; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia., Garnish SE; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia., Horne CR; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia., Luo C; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia., Garnier JM; SYNthesis med chem, 30 Flemington Rd, Parkville, VIC, 3052, Australia., Liang LY; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia., Cowan AD; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia., Samson AL; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia., Lessene G; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia., Sandow JJ; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia., Czabotar PE; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia. czabotar@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia. czabotar@wehi.edu.au., Murphy JM; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia. jamesm@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia. jamesm@wehi.edu.au.
Source: Nature communications [Nat Commun] 2021 Nov 22; Vol. 12 (1), pp. 6783. Date of Electronic Publication: 2021 Nov 22.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis.
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  Data: <searchLink fieldCode="AU" term="%22Meng+Y%22">Meng Y</searchLink>; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Davies+KA%22">Davies KA</searchLink>; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Fitzgibbon+C%22">Fitzgibbon C</searchLink>; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Young+SN%22">Young SN</searchLink>; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Garnish+SE%22">Garnish SE</searchLink>; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Horne+CR%22">Horne CR</searchLink>; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Luo+C%22">Luo C</searchLink>; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Garnier+JM%22">Garnier JM</searchLink>; SYNthesis med chem, 30 Flemington Rd, Parkville, VIC, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Liang+LY%22">Liang LY</searchLink>; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Cowan+AD%22">Cowan AD</searchLink>; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Samson+AL%22">Samson AL</searchLink>; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Lessene+G%22">Lessene G</searchLink>; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Sandow+JJ%22">Sandow JJ</searchLink>; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Czabotar+PE%22">Czabotar PE</searchLink>; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia. czabotar@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia. czabotar@wehi.edu.au.<br /><searchLink fieldCode="AU" term="%22Murphy+JM%22">Murphy JM</searchLink>; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia. jamesm@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia. jamesm@wehi.edu.au.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2021 Nov 22; Vol. 12 (1), pp. 6783. <i>Date of Electronic Publication: </i>2021 Nov 22.
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