Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis. - Meng Y; Davies KA; Fitzgibbon C; Young SN; Garnish SE; Horne CR; Luo C; Garnier JM; Liang LY; Cowan AD; Samson AL; Lessene G; et al. (Nature communications, 2021)