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From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease.

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Title: From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease.
Authors: Brown AJH; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK., Bradley SJ; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK; The Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK., Marshall FH; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK., Brown GA; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK., Bennett KA; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK., Brown J; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK., Cansfield JE; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK., Cross DM; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK; Cross Pharma Consulting Ltd, 20-22 Wenlock Road, London, N17GU, UK., de Graaf C; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK., Hudson BD; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK., Dwomoh L; The Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK., Dias JM; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK., Errey JC; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK., Hurrell E; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK., Liptrot J; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK., Mattedi G; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK., Molloy C; The Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK., Nathan PJ; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK; Brain Mapping Unit, University of Cambridge, Department of Psychiatry, Herchel Smith Building, Cambridge, CB20SZ, UK., Okrasa K; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK., Osborne G; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK., Patel JC; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK., Pickworth M; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK., Robertson N; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK., Shahabi S; Eli Lilly & Co, Neuroscience Discovery, Erl Wood Manor, Windlesham, Surrey, GU20 6PH, UK., Bundgaard C; Eli Lilly & Co, Neuroscience Discovery, Erl Wood Manor, Windlesham, Surrey, GU20 6PH, UK; H. Lundbeck A/S, Neuroscience Research, Ottiliavej 9, 2500 Valby, Copenhagen, Denmark., Phillips K; Eli Lilly & Co, Neuroscience Discovery, Erl Wood Manor, Windlesham, Surrey, GU20 6PH, UK., Broad LM; Eli Lilly & Co, Neuroscience Discovery, Erl Wood Manor, Windlesham, Surrey, GU20 6PH, UK., Goonawardena AV; Center for Neuroscience, Biosciences Division, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA., Morairty SR; Center for Neuroscience, Biosciences Division, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA., Browning M; University Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX12JD, UK; P1vital, Manor house, Howbery Buisness Park, Wallingford, OX108BA, UK., Perini F; Centre for Cognitive Neuroscience - Duke-NUS Medical School, 8 College Road, 169857, Singapore., Dawson GR; University Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX12JD, UK., Deakin JFW; Neuroscience and Psychiatry Unit, University of Manchester, Manchester, M139PT UK., Smith RT; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK., Sexton PM; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville 3052, Victoria, Australia; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Victoria, Australia., Warneck J; Protogenia Consulting Ltd, PO-Box 289, Ely, CB79DR, UK., Vinson M; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK., Tasker T; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK., Tehan BG; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK., Teobald B; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK., Christopoulos A; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville 3052, Victoria, Australia., Langmead CJ; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville 3052, Victoria, Australia., Jazayeri A; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK., Cooke RM; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK., Rucktooa P; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK., Congreve MS; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK., Weir M; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK. Electronic address: malcolm.weir@soseiheptares.com., Tobin AB; The Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK. Electronic address: andrew.tobin@glasgow.ac.uk.
Source: Cell [Cell] 2021 Nov 24; Vol. 184 (24), pp. 5886-5901.e22.
Publication Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
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  Data: From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease.
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